Conserved Protein Domain Family
RING-H2_RNF32_rpt1
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cd16677: RING-H2_RNF32_rpt1 
first RING finger, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
RNF32 is mainly expressed in testis spermatogenesis, most likely in spermatocytes and/or in spermatids, suggesting a possible role in sperm formation. RNF32 contains two C3H2C3-type RING-H2 fingers separated by an IQ domain of unknown function. Although the biological function of RNF32 remains unclear, proteins with double RING-H2 fingers may act as scaffolds for binding several proteins that function in the same pathway. This model corresponds to the first RING-H2 finger.
Links
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Statistics
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PSSM-Id: 438339
Aligned: 22 rows
Threshold Bit Score: 79.6504
Created: 29-Jan-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-H2 fingers with bound zinc
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  #                # #  #  #                     #  #      
Q9H0A6       126 PCPICKEEFel---rpQVLLSCSHVFHKACLQAFEKFtn---------kKTCPLCRKNQYQ 174 human
AAI24628     120 PCAICREEFrl---qpQVLLSCSHVFHKVCLKSFEKFsg---------kKCCPMCRKEQYE 168 zebrafish
EKX53401     117 DCAICRESFra---daQVILSCSHVFHQDCLASFERFag---------aKSCPLCRMKNYE 165 Guillardia theta CCMP2712
KDO23482     143 PCSICREPFgv---spKVLLSCSHVFHQACLTSFERFlrt-------tdRVCPLCRKQNYE 193 Saprolegnia parasitica CBS 223.65
EFN52916      42 LCSICLAPFka---aaQVLLSCSHTFHATCLASFERFsreh----tgqaRCCPLCRCQAYQ 95  Chlorella variabilis
EFJ24491      38 GCPICHEIFir---gdQLLLSCSHVFHKQCLKRFEKFsr---------qRCCPVCRTEHYQ 86  Selaginella moellendorffii
EAR94468     253 QCPICLEDFkd---qgQIILSCSHVFHKQCLESFEKHnk---------vKTCPICRKQHYD 301 Tetrahymena thermophila SB210
CEP02826      93 PCAICHEHFkt---drQVLLSCSHTFHLDCLRSFERFsg---------tRTCPMCRRTDYE 141 Plasmodiophora brassicae
XP_024393092  96 PCPICLERFglk--kqQVILSCSHAFHKLCLQSFEKFsr---------iRCCPICRAEPYQ 145 Physcomitrium patens
CBH14752     173 VCCICQEPFyatmeqgQVLLNCHHVYHENCLRQFERFtrqlrgkydatpLSCPMCRNPHYH 233 Trypanosoma brucei gambiense DAL972

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