Conserved Protein Domain Family
Med12-PQL
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pfam12144: Med12-PQL 
Eukaryotic Mediator 12 catenin-binding domain
This domain is found in eukaryotes, and is typically between 325 and 354 amino acids in length. Both development and carcinogenesis are driven by signal transduction within the canonical Wnt/beta-catenin pathway through both programmed and unprogrammed changes in gene transcription. Beta-catenin physically and functionally targets this PQL (proline-, glutamine-, leucine-rich) region of the Med12 subunit of Mediator to activate transcription. The beta-catenin transactivation domain binds directly to isolated Med12 and intact Mediator both in vitro and in vivo, and Mediator is recruited to Wnt-responsive genes in a beta-catenin-dependent manner.
Links
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Statistics
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PSSM-Id: 463471
Aligned: 11 rows
Threshold Bit Score: 187.736
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005201865 1814 QVMHHPQSALWGYNlMGQPQQPGFFLQNQSVTP----GGS---RLDPAgsFVptntkqaLSNMLQRRSGA--M-MQpps- 1882
3_pfamImport    1 QMMHHHQSALWGYNvMGQPPQTGFFVQNQPVPP----ANPakvCPCLP--YK-------LSMWKMARSKTfaTtFFntl- 66  
XP_008119976 1806 DLLHHQTANSMSRL-AYGQSPVGLYAQNQPLPA----GGP---RLDTS--YRpvr-mpqIGKLVPSRPPY--TgVLpts- 1871
AAI10697      369 DLLHHANPGSISHL-SYRQSSMGLYTQNQPLPA----GGP---RVD-P--YRpvr--lpMQKL-PTRPTY--PgVLptt- 431  house mouse
XP_012408847 1798 DLLHHAPGSSISRF-GYPQTPVTLYTQNQPLPA----GGP---RLDTT--YRpvr--mpVPKL-QTRPSY--SgVLpsp- 1861 Tasmanian devil
XP_014349674 1818 DLLHHQPMHPYSRV-NYGQSSMGVYTQNQPLPA----GGP---RLDAT--YRpsa--rvpMKI-SNRPPY--SgIMppvm 1882 coelacanth
XP_015207115 1806 EMLHGQQGHPFNRM-VYGPQSMGMYPQNQPLPP----GGP---RLDTT--YRptr-------tlPMRPNR--PaAYpnmm 1866 spotted gar
XP_031410947 1865 QMMQHPHSALWGYTiMGQPQQPGFFAQNQPLPP----GGSr-lDPTSS--FVpantkqaLSNMLQRRSVLqpPsLH---- 1933 turkey
XP_022527628 1719 ELMNMGQSGHTYRM-GYNQTSI-IYTQNQPLPP----GGP---GLEPP--YRpr---mpVNKM-PTRPNY--PgNYhpg- 1780 Mexican tetra
TNN71273     1784 lmqnhP----YGRL-PYGQQTMGMYTQNQPLPP----GGP---GLEPP--YRpvr-npqMNKMMPTRPSY--PgMMpnmq 1846 Tanaka's snai...
XP_005467430 1791 ELMQNPT---YARTmPYNPQ--NVYTQSQPLPPgqitGGP---GLDAP--YRqpt-rnqIPKMMPARTNY--PtMMpgmp 1857 Nile tilapia

XP_005201865 1883 -------lhaITSQQ-QLIQMKLLQ-QQ----QQQRLLRQAQ-----TRPFQQGQpGDQaalfaaQ-ARP---------S 1934
3_pfamImport   67 --------csAQYLGtQIYKVFIFLkQGptidQAAIYSQQAR-----PSQLPQYP-GMQ------Q-AQG---------K 116 
XP_008119976 1872 -------mssMMSID-QAYKSSVYRqQQppvpQGQLLRQQLQ-----AKLQGQGMvGPQ------P-LRQ---------M 1922
AAI10697      432 -------mstVMGLEpSSYKTSVYRqQQptvpQGQRLRQQLQ-----AKI-SQGMlGQS------S-VHQ---------M 482  house mouse
XP_012408847 1862 -------itgVISID-PSYKTPVYRqQQppvpQGQLLRQQLQ-----AKL-SQGMlGQP------P-VRQ---------M 1911 Tasmanian devil
XP_014349674 1883 p-----giggIMSLDqQSYKQGGYR-PQpppsQGQLLRQQLV-----AKLQNQAMgSH----------RQ---------M 1932 coelacanth
XP_015207115 1867 tgmpggvgnlITALDqQAYRA--YK-PQpp-iQGQILRQQLQ-----AKL-SQGMlGQ-------Q-VRQ---------M 1919 spotted gar
XP_031410947 1934 ----------AVTPQqQLLQMKLLQqEQ----QQRLLRHQAQ-----ARSLQQDVsSSA------VsLQDgfdnimgqpM 1988 turkey
XP_022527628 1781 -------gmgIMGMDnKQYTMG-FK-PQtamsQGQMLRQQIQvrlnqSML------GQ-------Q-MRP---------M 1828 Mexican tetra
TNN71273     1847 g-----smpgMMGMD-KQYPMG-YK-PQstmaQGQILRQHLQ-----VRL-NQSMiGQ-------Q-IRQ---------I 1895 Tanaka's snai...
XP_005467430 1858 g-----smpgIMGPD-KPYQMT-FK-PHatmpQAPNLRQQLQ-----VRL-HQNPnALG------Q-IRQ---------M 1907 Nile tilapia

XP_005201865 1935 PQLPQY---------------PGLQqa-qT-MP----QGYTMYGTQMPLQQTpqqQAGSVVlSPTYNSRTYPAAH--SNP 1991
3_pfamImport  117 HSMPIY---------------TEIA----LaIP----HGYTMYSTQMSLQSQ---QSGGLVlSPAYSPRAYQVAH--SNP 168 
XP_008119976 1923 APTPSY---------------GAVQ------PS----QGYTPYVSHIGLQQHp-sQSGAMV-PPSYSSQTYQNAHpgSNP 1975
AAI10697      483 TPSSSY---------------G-LQ------TS----QGYTSYVSHVGLQQHt-gPAGTMV-PPSYSSQPYQSTHpsTNP 534  house mouse
XP_012408847 1912 TPNSSY---------------GSLQ------AS----QGYTPYGSHIGLQQHt-gPAGTMV-PPSYSSQPYQSPHpaANP 1964 Tasmanian devil
XP_014349674 1933 NPTSSY---------------GSLQ------APqnmsQGYTPYGSHLGLQQQl-pQAAGMV-LPTYSGQAFp----gSNP 1985 coelacanth
XP_015207115 1920 PPNPSY---------------GTLQp----------tQGYTSYGPHMGMQQHp-sQTGGMV-PPAYANQPFQGSHpaPNP 1972 spotted gar
XP_031410947 1989 DPAALFtpqvrptpqlpqypgLQQA----QgMP----HGYTMYSTPMPLQQQ---QPGSVVlSPGYTPRAY-TAH--SSP 2054 turkey
XP_022527628 1829 APNQQY---------------SSMQpaqnI-SQ----QGYTSYGSHMVMQPHp-sQTGAIV-PSQYGNQAFQGAHpgTNP 1886 Mexican tetra
TNN71273     1896 TPNQPY---------------TSMQas-qN-IS----QGYTTYGSHMGMQQHp-sQGGGIV-PSSYGNQNFQGTHpgANP 1952 Tanaka's snai...
XP_005467430 1908 PPNQQY---------------TSMQ------TS----QGYTTYGSHMGMQQHp-sQSGSIV-PHSYGNQNFPGAHpgANP 1960 Nile tilapia

XP_005201865 1992 ALMERLRQMQQPPSGYVQQQAS-PYLHPLTGSQRLNHQSLQ 2031
3_pfamImport  169 ALMERLRQIQQQPSGYIHQQAA-AYLQPLTGNQRLSHQALQ 208 
XP_008119976 1976 TFVDPTRTM-QRPSGYVHQQAP-GYVHSLSAAQRFPHQSMQ 2014
AAI10697      535 TLVDPTRHLQQRPSGYVHQQAP-TYGHGLTSTQRFSHQTLQ 574  house mouse
XP_012408847 1965 TLVDPARHLQQRPSGYVHQQAP-GYGHGLPTTQRFAHQSLQ 2004 Tasmanian devil
XP_014349674 1986 ALIDSVRQIQQRPSGYVHQQAP-GYSHSLQNPQRFTHQPMQ 2025 coelacanth
XP_015207115 1973 AMVDSLRQMQQRPSGYIHQQAP-GYVHAMQNTPRFAHQQAS 2012 spotted gar
XP_031410947 2055 VLMERLRPGQ--PGGVAQQQAA-AYMQPLTGAQRLTHQPLQ 2092 turkey
XP_022527628 1887 GVVDPLRQM-PRPSGYVHQQASsAYG--MQNTQRFAHQPMQ 1924 Mexican tetra
TNN71273     1953 AVVDPLRQMQQRPSGYVHQQAP-GYAHNMQNSQRFAHQPLQ 1992 Tanaka's snailfish
XP_005467430 1961 AVVDPLRQ--QRPSGYLLQQAP-GYPQSMQNTQRFPHQQLQ 1998 Nile tilapia
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