3ZZO


Conserved Protein Domain Family
Diedel

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pfam13164: Diedel 
Diedel
Diedel (die) was identified as an insect immune response protein. It is up-regulated after a septic injury and may act as a negative regulator of the JAK/STAT signalling pathway. Its homologs can be found in Drosophila and Acyrtosiphon pisum. Interestingly, the orthologues of the die gene are present in the genome of insect DNA viruses of the Baculoviridae and Ascoviridae families. The viral homologs suppress the immune deficiency (IMD) pathway in Drosophila.
Statistics
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PSSM-Id: 463795
Aligned: 15 rows
Threshold Bit Score: 70.0567
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3ZZO_A                2 CCtSRELVEFKM--DRG--DCEAVRA-IENYPNgCEVTICADGVAQ-LGAYCGQGPCNIFGCNCDGGCLSG--DWSQEFV 73 
EDX14861             21 CCtSAATLHFKI--RGG--VCGIVGA-KSNGTG-CKITICPNGEAL-VGSYCGKAACDVFGCQCIRGCLQG--SFAKDFL 91 
WGS:AAPP:GF15938-PA  26 CCrSKANLKYTI--EGG--DCGAVGG-RRTSDG-CTITICGNGRAV-VGTWCGRGSCNIFGCACKGGCLSG--DFALDFI 96 
WGS:AAPU:GI24243-PA  24 CCrRSMVLTYTV--GRG--RCGDAGG-RAGRGGtCSIVICAHGKRK-VGTYCGRRSCNIFGCNCGGGCIEG--QWQRSFI 95 
XP_002008436         28 CCaEAKVVKYKV--LNG--QCAAIRG-QRSDDGnCVIKICGDGRPL-RGTYCGRGSCNLAGCDCDGGCLPG--DWEKSLS 99 
XP_002047577         20 CCvDAKKLDYTV--EDG--TCASAGG-KASGNGkCVITICGNGEAL-RGAYCGRGSCNVFGCDCDGGCLGS--GWEQTFL 91 
KMZ10558             26 CCwTKAKLLFTM--GKG--SCGMVNA-KTTKYG-CEATVCADGRVL-KGSYCGVGSCNIFGCFCRGGCLAG--NYGESFV 96 
XP_002058609         26 CC-RPSKILYKLanNGKdhNCQTYGG-KYHNKEtCEKKVCGNGDGI-VGTWCGRGKCNPRGCHCRNGCLPG--EATASFR 100
EDW39078             26 CC-KPTKIRFELaaNNGthTCETYGG-KPGKNYtCKAKICNDGNNV-RGTWCGKGRCNPSGCHCKKGCLASgaSAIDSFR 102
1_pfamImport          1 CC-DKTNVFFNIiePNR--TCRDFGAvESSLPDlCSIFVCGNGYPPaDGYYCGVGSCNIFGCNCDLGCVYG--DARKNFK 75 
3ZZO_A               74 RRN 76 
EDX14861             92 QKN 94 
WGS:AAPP:GF15938-PA  97 KNN 99 
WGS:AAPU:GI24243-PA  96 NNN 98 
XP_002008436        100 TGV 102
XP_002047577         92 QNA 94 
KMZ10558             97 EIN 99 
XP_002058609        101 EKH 103
EDW39078            103 EKH 105
1_pfamImport         76 RR- 77 
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