Conserved Protein Domain Family
Rad51D
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cd19489: Rad51D 
RAD51D recombinase
RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51D, together with the other RAD51 paralogs, RAD51B, RAD51C, XRCC3, and XRCC2, helps recruit RAD51 to the break site.
Links
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Statistics
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PSSM-Id: 410897
Aligned: 21 rows
Threshold Bit Score: 152.79
Created: 16-May-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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ATP binding
Feature 1:ATP binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                        ######                         #                                
AAC39719      55 DAGLYTGEVTEIVGGpGSGKTQVCLCMAANVAHgl---qQNVLYVDSNGGLTASRLlqllqaktqd-------------- 117 human
NP_001086359  94 DSGLYTGEVTEIAGAaGSGKTQMCQSIAVNVAYsl---kQTVLYVDTTGGLTASRLlqlvqsrten-------------- 156 African clawed ...
XP_002128226  94 DAGIYTGEVTEIVGPsSSGKTQLCETFAVNVAAsf---dQNVIYIDTAGGFSAVRVgeifkkrfs--------------- 155 Ciona intestinalis
XP_001869974  96 QGGLLPGHVLEVFGEpACGKSQLCMTIAANVASrgaadpVDVFYVDTKCDFSASRVqsmllagkcs-------------- 161 southern house ...
XP_002405692  94 GGGVFTGQITEIVGAsTSGKTQLCHSLTAHAVIds---hFGVLYVDTLSCFSAERIrqilssaqq--------------- 155 black-legged tick
EFN68270       7 KGGLYPGQLCELCGPsSSGKTQLCLTIAANVAVqs---dIIVWYFDTKRDFSRFRYeeilkaknfr-------------- 69  Camponotus flor...
EGF84484     101 DGGLQSGQIIEFAGLpASGKTQLCHFISAEMIAss--plLRVTYIDSGGTFYASRIlemisgdgfskrf----------- 167 Batrachochytriu...
XP_002683580 145 DGGIQCGELTEIVGFqSSGKTCLCKTVSLNTIIek--nsDTVLWISTNSSFNAREFammyesksnlyneqirqsqatqqs 222 Naegleria grube...
EFA10219      94 NGGLFTGNIYELCGPpASGKTHFVLTLIKNVILnm---dQNVHIFDTKNDFSAVKMkqmlkncde--------------- 155 red flour beetle
XP_002426153  94 NGGFITGNIYELCGYeGCGKTQICMTTAIKICSrt---pHKVLFFDTKYDISINRLnqilnyekn--------------- 155 human body louse

Feature 1                                                                                    #   
AAC39719     118 ------eeeqaealrRIQVVHAFDifqmlDVLQELRGTVAQQVtgs---------------------sgTVKVVVVDSVT 170 human
NP_001086359 157 ------edeqvaslqRIEVIRVFDiykllDAFQDLRHKISQQLlrs---------------------gePLRLVIIDSVC 209 African clawed ...
XP_002128226 156 ------shntsatlsRIRVSRCFEvselrETLDLVRRKMSAQDetf---------------------fsSLKVVIIDSVT 208 Ciona intestinalis
XP_001869974 162 ------eeeareamqRIKVERIHSpehllGTVEEMLAQIDQEErf-----------------------gKFRVLLVDSLP 212 southern house ...
XP_002405692 156 ------sakpdqlmqRVCHIGIRDigelvQLVDQIRNSLERRAnse---------------------laSIKMIVVDSLK 208 black-legged tick
EFN68270      70 ------qevikdtlqRTKVCHIRSprdliRVLRELVTFYKTEQnsvs------------------fggrRFPLVIIDSLP 125 Camponotus flor...
EGF84484     168 ---nqtlqdsadmlqRITHVRCFNafeviRYLQTLSTPSNHKVeqndanlellstcsniqalesnqpaqPPHLIIIDSVG 244 Batrachochytriu...
XP_002683580 223 qveadeicslvetftKIRVLDVSTpeelkTLLIELVKLIESEQdnf---------------------ynSLRLVVIDSLA 281 Naegleria grube...
EFA10219     156 -------drrtkslgKIIVNRCYTrydliNSLYEIKNDLENNM--------------------------KLRLIIVDSLP 202 red flour beetle
XP_002426153 156 -------lnknkvleKIEICHSTTpykllNDLHHLKVAFSNSKek----------------------ylGFKIIIIDSIS 206 human body louse

Feature 1                                                     #                                  
AAC39719     171 AVVSPLlgg-----qqrEGLALMMQLARELKTLARdlGMAVVVTNHItrdrds--------------------------- 218 human
NP_001086359 210 AVIYPMlgg-----khtEGMAIMMQLARELQTMAHdyHLAILISNSItkdgaa--------------------------- 257 African clawed ...
XP_002128226 209 SLLSTVlyng----tfvEGMASLQSIGRQLNALAKdfALAVVITNDMvtgpqdkt------------------------- 259 Ciona intestinalis
XP_001869974 213 ALWYAHqnss----sscYPVGMLTSLAGLLRKLASenMIAVVVVNLRivstdsgq------------------------- 263 southern house ...
XP_002405692 209 AAVSPVltgd----qyvEGLGLLAHLAIAFQYIAArfRVAVVVTNDVvtgpng--------------------------- 257 black-legged tick
EFN68270     126 AVIFKVtreah--qcdlETTYELDDLAEACRFLTRecEAIVITVNSVtrwnssdqi------------------------ 179 Camponotus flor...
EGF84484     245 QLFSPLig--------qGGYATLGSFSDLIQKLAKtlYIPIITVNTSvsagfidnrvdggeslafstnasqnhssqnhlg 316 Batrachochytriu...
XP_002683580 282 VILTSLvqskvnskiseKEDLSLDEIIRLMKKIARkyQIAFLYTNYTlheld---------------------------- 333 Naegleria grube...
EFA10219     203 GVILNSnd-------hlTNNLYLNHIANIMRYIATehHVAFLVTNLIttwtdggfkt----------------------- 252 red flour beetle
XP_002426153 207 SLFQLHqv-------isKGLEFLNDVASVIKFLAFeyQLVILITNFLtswinsnslcenese------------------ 261 human body louse

Feature 1                                       #                                                
AAC39719     219 ---------grlkpaLGRSWSFVPSTRILLDTiegag------------------------------------------- 246 human
NP_001086359 258 ----------sirpaLGRSWSFVPSTRILLTQnel--------------------------------------------- 282 African clawed ...
XP_002128226 260 -------gqfsrkpaLGRVWTFVPSVRVQLQPhia--------------------------------------------- 287 Ciona intestinalis
XP_001869974 264 --------qrvtqpaLGRYWEMVPTTRLLMSKldsg-------------------------------------------- 291 southern house ...
XP_002405692 258 ----------mmkpaLGKYWADVPSLSLEVSLvddl-------------------------------------------- 283 black-legged tick
EFN68270     180 -------dpaaitpaLGRYWARVPVTRLLIIRqhgetrritvwkdlrsdeksfcivtidirmnvkryihprnkykkppdy 252 Camponotus flor...
EGF84484     317 fgmadgfrqvstkpaLGGMWDAVPYYRLYFTTslndgradl--------------------------------------- 357 Batrachochytriu...
XP_002683580 334 -----------drtvLGETCKYFSHVRLLSKKlekqpp------------------------------------------ 360 Naegleria grube...
EFA10219     253 ------qqetsetitCGKYWSSVPNTRLRIEKmen--------------------------------------------- 281 red flour beetle
XP_002426153 262 -sdeilnnrkiekpaLGKFWTHVPNTRIIVKKkdc--------------------------------------------- 295 human body louse

Feature 1                                                  
AAC39719     247 -----------------------------asggRRMACLAKS 259 human
NP_001086359 283 ------------------------------ncgLCTVSLVKS 294 African clawed frog
XP_002128226 288 -------------------------------pcLHHVGVNKI 298 Ciona intestinalis
XP_001869974 292 -----------------------------dngqNRLISISKC 304 southern house mosquito
XP_002405692 284 ------------------------------ysdLRRLLVAKS 295 black-legged tick
EFN68270     253 kqlavlypefreiaimdiagkirinfqdkkslrVLTETLLKH 294 Camponotus floridanus
EGF84484     358 ------------------------yrvydesssFKPRSLSKI 375 Batrachochytrium dendrobatidis JAM81
XP_002683580 361 ----------------------------keegtFFEAHLLKS 374 Naegleria gruberi strain NEG-M
EFA10219     282 -------------------------------sgGCKLSVLRS 292 red flour beetle
XP_002426153 296 -------------------------------sdECLLTISKS 306 human body louse

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