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ER membrane protein complex subunit 7, beta-sandwich domain This is the beta-sandwich domain found in ER membrane protein complex subunit 7 (EMC7), which is an integral membrane component of the EMC. EMC is widely conserved and involved in membrane protein biogenesis. It mediates the insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins in an energy-independent manner, both post-translational insertions of tail-anchored proteins and co-translational insertion of multipass membrane proteins. This entry includes UPF0620 protein C83.10 from S. pombe, an orthologue of animal EMC7. This domain is also found in nodal modulators, which have been identified as part of a protein complex that participates in the nodal signalling pathway during vertebrate development.
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Jiyao W et al.(2023). "The conserved domain database in 2023.",