Conserved Protein Domain Family
CWC25
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pfam12542: CWC25 
Pre-mRNA splicing factor
This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with pfam10197. There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.
Links
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Statistics
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PSSM-Id: 463626
Aligned: 112 rows
Threshold Bit Score: 43.5896
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KJE93312      67 AQRLEWMYT---------GQ--AV---AASRQQEEYLLGKR-V--------SdttsaGAPasslsqasgvagslfvgaga 123
ABN66778      89 LSKLNWMYDdm-----pkTDeptenssgFTESNEEFLEGKTkVenll-ngnKafnrn----------------------- 139
XP_007375454  74 LSKLNWMYEdvp---feeKEeevkndagFIESSNEFTEGKSkVenll-kgnHsfkrtiq--------------------- 128
XP_001524861  74 VSKLSWMYEdvp----feKPtettnssgFIESNQEFVEGKAeVenml-ngkIamkrnKGN-------------------- 128
CCE43994      74 VSKLSWMYEdvp---fekQEtetmsssgFIETTTEFTEGKTeAenll-sgnRafk------------------------- 124
Q59LQ5        74 ISKLNWMYDdvpfegnekVEenSS---GFIESNVEFTDGKSkVenllkgnhVvgkkrdg--------------------- 129 Candida albican...
EER31009      74 LSKLNWMYDdvp---fenNEqveenssgFIESSLEFTEGKSkVenmlngnnNmvs------------------------- 125
EMG46424      74 LSKLNWMYDdvp---fenNEqveenssgFIESSLEFTEGKSkVenll-ngnRais------------------------- 124
XP_004194643  71 LNKLGWMYDd--------NKpke---egFNEVEDEFLLGKKkVesml-sgnQaleva----------------------- 115
Q6BNE1        71 LNNLNWMYDd--------SKsgnksnseFNDMDDEFLLGKRkVenml-sgnKyidtk----------------------- 118 Debaryomyces ha...

KJE93312     124 gagagaggsaggagksglpAQSGavqgslaaITQVaPSALDMANK---------------IREDPMYLIKKKEQESLQAL 188
ABN66778     140 --------------------------kpsdnINRIiNVGKTVSSDnk------------vAQEDPLLSIRSQQQRIIRNQ 181
XP_007375454 129 -------------------------ssssdrLNKViGVGISKPSGss------------dLSDDPLLRIKQQQQLQRMNQ 171
XP_001524861 129 -------------------NEGRneaggserMNKIlSVGITGNNSgknmnkindaknlrsYGDDPLAMIKQQQQQQQQQQ 189
CCE43994     125 --------------------khDtngfanerMNKViGTGSKKPNSt-------------nYGDDPLAMIQKQQVGQQRlk 171
Q59LQ5       130 -------------------------sgtsdrINKIiGVGMTKSSKv-------------sYSDDPLLKIKQQQQQAQRVA 171 Candida albican...
EER31009     126 --------------------rkRdrgdhsdrINKIiGVGMSKPQKtt------------sYSDDPLAKIKQQQQQQQQAQ 173
EMG46424     125 --------------------rkRsgndssdrINKIiGVGMSKSSKst------------tYSDDPLAKIKQKQKQQQAlk 172
XP_004194643 116 ---------------------------eksrFETIiDNPKRKSGAd--------------LNDDPLLKIKQVQAKKSRHK 154
Q6BNE1       119 ---------------------------etsrFEEAiSS-SNNGDKn--------------IQNDPLIRIKNEQLKKYQSV 156 Debaryomyces ha...

KJE93312     189 LSN 191
ABN66778     182 QEK 184
XP_007375454 172 KKh 174
XP_001524861 190 KQK 192
CCE43994     172 qrd 174
Q59LQ5       172 RKQ 174 Candida albicans SC5314
EER31009     174 RSs 176
EMG46424     173 sak 175
XP_004194643 155 Hrd 157
Q6BNE1       157 KDs 159 Debaryomyces hansenii CBS767
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