4JS1,4MPS,4JS2,6QVS,6QVT


Conserved Protein Domain Family
GT29_ST6GAL1
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cd23985: GT29_ST6GAL1 
beta-galactoside alpha-2,6-sialyltransferase 1
ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).
Links
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Statistics
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PSSM-Id: 467713
Aligned: 12 rows
Threshold Bit Score: 533.901
Created: 28-Nov-2018
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:4JS1: Human beta-galactoside alpha-2,6-sialyltransferase 1 binds cytidine and phosphate, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                ###                    #
4JS1_A        49 AEALRCHLRDH-VNVSMVEVTd-FPFNTSewegylpk---esirtkagPWGRCAVVSSAGSlkssqlGREIDDHDAVLRF 123 human
4MPS_A        41 VEALRCHLRDH-VNVSXIEATd-FPFNTTewegylpk---enfrtkvgPWQRCAVVSSAGSlknsqlGREIDNHDAVLRF 115 Norway rat
4JS2_A        49 AEALRCHLRDH-VNVSMVEVTd-FPFNTSewegylpk---esirtkagPWGRCAVVSSAGSlkssqlGREIDDHDAVLRF 123 Homo sapiens
6QVS_A         6 AEALRCHLRDH-VNVSMVEVTd-FPFNTSewegylpk---esirtkagPWGRCAVVSSAGSlkssqlGREIDDHDAVLRF 80  Homo sapiens
6QVT_A         6 AEALRCHLRDH-VNVSMVEVTd-FPFNTSewegylpk---esirtkagPWGRCAVVSSAGSlkssqlGREIDDHDAVLRF 80  Homo sapiens
Q92182       143 PEQLLCRLRDR-VNVTMIRGSd-GPFNSSewqhylpd---kslnetvgRLGRCAVVSSAGSlksshlGPEIDSHDAVLRF 217 chicken
NP_001243216 203 PQELLCAIKTK-VNISTLVTAd-LPQNADswsqylpr---ktlqeevkSLGKCAVVSSAGSikhsrlGQEIDTHDAVLRF 277 tropical clawed...
XP_029471670 154 AKELLCELKTK-VEVKMLQGTd-IPSKESdwkkylpk---kslreevrQLGRCAIVTSAGSikssglGREIDSHDAVLRF 228 two-lined caeci...
XP_007885730 193 REELICELKQR-VPVKTIQFGe-DPFTTSdwqkslps---kslmeelgQFRTCAVVSSAASilhsklGNEINGHDAVLRF 267 elephant shark
XP_028650586 146 REELLCELKSKlYPVKMLTLAdgFPVGKDkhddwksylptkpfkdvfgKLKRCAVVSSAGSlrwsglGREIDEHDAVLRF 225 reedfish
NP_001003853 206 GPEILCEIKEK-VQVTTLTPDm-EPFSGFpwgsqlpp---rqitsdvgPFKTCAVVSSAGSlknsglGKEIDSHDAVIRF 280 zebrafish
XP_013918058 185 GMDLMCQLKSR-VTVSTVLGDe-GPFAEPvwramlpq---rslaeefgHLKTCAVVSSAGSmlgsglGNEIDSHHAVLRF 259 Thamnophis sirt...

Feature 1        #                     #                                                         
4JS1_A       124 NgAPTANfq-qDVGtKTTIRLMNSqlvttekr-flkdslynEGILIVWDPSvyhsDIPKWYQNPdynfFNNYKTYRKLHP 201 human
4MPS_A       116 NgAPTDNfq-qDVGsKTTIRLXNSqlvttekr-flkdslytEGILIVWDPSvyhaDIPKWYQKPdynfFETYKSYRRLNP 193 Norway rat
4JS2_A       124 NgAPTANfq-qDVGtKTTIRLMNSqlvttekr-flkdslynEGILIVWDPSvyhsDIPKWYQNPdynfFNNYKTYRKLHP 201 Homo sapiens
6QVS_A        81 NgAPTANfq-qDVGtKTTIRLMNSqlvttekr-flkdslynEGILIVWDPSvyhsDIPKWYQNPdynfFNNYKTYRKLHP 158 Homo sapiens
6QVT_A        81 NgAPTANfq-qDVGtKTTIRLMNSqlvttekr-flkdslynEGILIVWDPSvyhsDIPKWYQNPdynfFNNYKTYRKLHP 158 Homo sapiens
Q92182       218 NgAPVKGfq-eDVGqKTTIRLVNSqlvtveeqqflkdalynTGILIVWDPApyhaEIHEWYRKPdykfFEAYKSYRIRHP 296 chicken
NP_001243216 278 NaAPVLGyq-dDVGtKTTFRLLNSqlvsrpelkfledplykEGSLIMWDPApynaNVEEWHKNPdykfFERYSEYRRRNP 356 tropical clawed...
XP_029471670 229 NgAPTIGfh-qDVGeKTTIRLINSqvvtleehkfltetlynFGILIVWDPApyhsEASEWYKRPeykfFDNYQRQRQKNP 307 two-lined caeci...
XP_007885730 268 NaAPTSGfe-fDVGtKTTIRIINSqvistgdyqfhakslyrTGVLLTWDPApyaaNLSEWFKNPdynfFEDYKKYRENNP 346 elephant shark
XP_028650586 226 NaAPTSArfirDVGsKTSIRFINSqvvsteahrfltdplyrDTVLVMWDPApyskNITHWFNNPdysfFDKYKEYRIKNP 305 reedfish
NP_001003853 281 NaAPTAGfe-tDVGsKTTVRLINSqlmasedhhflssslysAGILVSWDPSpyssDLWEWFNKTdypiFKQYQRYRRLHP 359 zebrafish
XP_013918058 260 NgAPTAGye-hDVGtKTTLRLVNSqlmvspnhnfldeqlyaEGTLVAWDPApypgDLEEWYKSPdyplFEPFRTLRTKRP 338 Thamnophis sirt...

Feature 1                                        ###                 ##        ###               
4JS1_A       202 nQPFYILkpQMPWELWDILQEIspeeiqpnppSSGMLGIIIMMTlCDQVDIYEFlpskrkTDVCYYYQKFfdsactmgay 281 human
4MPS_A       194 sQPFYILkpQXPWELWDIIQEIsadliqpnppSSGXLGIIIXXTlCDQVDIYEFlpskrkTDVCYYHQKFfdsactxgay 273 Norway rat
4JS2_A       202 nQPFYILkpQMPWELWDILQEIspeeiqpnppSSGMLGIIIMMTlCDQVDIYEFlpskrkTDVCYYYQKFfdsactmgay 281 Homo sapiens
6QVS_A       159 nQPFYILkpQMPWELWDILQEIspeeiqpnppSSGMLGIIIMMTlCDQVDIYEFlpskrkTDVCYYYQKFfdsactmgay 238 Homo sapiens
6QVT_A       159 nQPFYILkpQMPWELWDILQEIspeeiqpnppSSGMLGIIIMMTlCDQVDIYEFlpskrkTDVCYYYQKFfdsactmgay 238 Homo sapiens
Q92182       297 eQPFYILnpKMQWQLWDILQENslehiqpnppSSGMLGIVIMMTlCDEVDVYEFlpskrqTDICHYYQKFhdhactmgay 376 chicken
NP_001243216 357 eQMFYVLnpHAAWQLWDIIQQNapedinpgppSSGLLGILLMMNlCDQVNVYEFlpsrrqSDLCHYYERYqdractlgay 436 tropical clawed...
XP_029471670 308 dQPFYILhpKVQWQIWDILQENtpediqpnppSSGMLGILLMMDlCDEVNIYEFlpskrqTDVCHYYQRFldracvmgay 387 two-lined caeci...
XP_007885730 347 eQPFHILhpSIQWKLWNIVQENtaeniqpnppSSGLMGIVLMMTlCDQTDVYEFlpsqrqTDRCHYYEMFhdqactmgay 426 elephant shark
XP_028650586 306 nQFFYVMnpSFQWDLWDIIQDNsddniqknppSSGIQGIILMMSlCEEVNVYEFlpsrrkTDVCHYYQSFqdracivgay 385 reedfish
NP_001003853 360 qQPFYIVhpRMEWQLWQRIQDNmgeaiqknppSSGLLGTVLMMSlCEVVHVYEFlpsrrkTELCHYYQRFsdaactlgay 439 zebrafish
XP_013918058 339 wQLFHLLhpRLQWEIWELVQEGadeqvqrnppSSGMLGIVLMMSlCKLVHVYEFlpsqrqTHLCHYYQHFsdaactlgay 418 Thamnophis sirt...

Feature 1        #                               
4JS1_A       282 HPLLYEKNLVKHLnqGTDEDIYLLGKATLPGF 313 human
4MPS_A       274 HPLLFEKNXVKHLneGTDEDIYLFGKATLSGF 305 Norway rat
4JS2_A       282 HPLLYEKNLVKHLnqGTDEDIYLLGKATLPGF 313 Homo sapiens
6QVS_A       239 HPLLYEKNLVKHLnqGTDEDIYLLGKATLPGF 270 Homo sapiens
6QVT_A       239 HPLLYEKNLVKHLnqGTDEDIYLLGKATLPGF 270 Homo sapiens
Q92182       377 HPLLFEKNLVKHLnqGTDEDIYTHGKVTLPGF 408 chicken
NP_001243216 437 HPLMYEKNLVKKLnlGDDNSIFHFGRITLPGL 468 tropical clawed frog
XP_029471670 388 HPLLFEKNLVKHIsqGKDEHIYLKGKVTLPGF 419 two-lined caecilian
XP_007885730 427 HPLMFEKNLVKRMnhGTDEEIHMYGKVTLPGF 458 elephant shark
XP_028650586 386 HPLLYEKNLIKRInsGSDNDIYYYGKAVLKGF 417 reedfish
NP_001003853 440 HPLLYEKNLVKRMnqGSDRDIYTLGRVTLPGF 471 zebrafish
XP_013918058 419 HPLLFEKNLVRRMnrGTLADLAEKGRVTLPGF 450 Thamnophis sirtalis

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