6F1T


Conserved Protein Domain Family
DLIC

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pfam05783: DLIC 
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Dynein light intermediate chain (DLIC)
This family consists of several eukaryotic dynein light intermediate chain proteins. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. DLIC1 is known to be involved in assembly, organization, and function of centrosomes and mitotic spindles when bound to pericentrin. DLIC2 is a subunit of cytoplasmic dynein 2 that may play a role in maintaining Golgi organization by binding cytoplasmic dynein 2 to its Golgi-associated cargo.
Statistics
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Structure
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PubMed ReferencesClick to see Conserved Features Help

pfam05783 is the only member of the superfamily cl25911
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6F1T_i        30 EEGQSLWSSILSEVSTRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWIL 109
Q16RB5        26 DPKENLWSAILSEVQTQSSTKLPSNKSVLVLGDNASGKTTLIAKLQGVEDPKKGSGLEYAYIDVRDEYRDDVTRLGVWIL 105 yellow fever mo...
XP_015041575  27 AEKENLWSAILNEVQTQGSTKLPANKSVLVLGDNATGKTTLIAKLQGVEDPKKGSGLEYAYIDVKDEYRDDMTRLGVWVL 106
Q6PDL0        30 EEGQSLWSSILSEVSTRARSKLPSGKNILVFGEDGSGKTTLMTKLQGAEHGKKGRGLEYLYLSVHDEDRDDHTRCNVWIL 109 house mouse
NP_001017669  26 DEGQNLWSSILSEVSTRSSSKLPSGKNVLLFGEDGSGKTTLMSKLQGAEHNKKGRGLEYLYLNVQDEDIDDLTRCSVWIL 105
Q1LUM9        29 EDGQNLWSSILSEVSTRSRSKLPSGKNVVVMGEVGSGKTTLVAKLQGVEEYMKGRGLEYLYFNVHDDDIDDQSRCNAWVL 108 zebrafish
Q90828        33 DDGQNLWSCILSEVSTRSRSKLPSGKSVLLLGEDGAGKTSLIGKIQGIEEYKKGRGMEYLYLNVHDEDRDDQTRCNVRIL 112 chicken
6F1T_i       110 DGDLYHKGLLKFAVSAESLPETLVIFVADMSRPWTVMESLQKWASVLREHIDKMKIPPEKMRELERKFVKDFQDYMEPEE 189
Q16RB5       106 DGDPGHTNLLKYALNETNYAHTLVILTLSMTTPWSWVDQLEHWIKMLDDHIAGLKIDPEERQQCRQRLVTVWQSYCDTID 185 yellow fever mo...
XP_015041575 107 DGDPGHTNLLHFALNETNYAHTLVILTVSMTQPWGWLEQLNHWIKVLGQHIESLPLEAKDKEMARQRLATTWQSYCEVGD 186
Q6PDL0       110 DGDLYHKGLLKFAVSAESLRETLVIFVADMSRPWTIMESLQKWASVLREHIDKMKIPPEEMRDLERKFMKEFQDYIEPEE 189 house mouse
NP_001017669 106 DGDLYHKGLLKFAVTAESLKDSLAVFVVDMSRPWTIMESLQKWTSVLREHVDKLRIPPEEMREMEQRMVKAFQEYVEPEE 185
Q1LUM9       109 DGDLYHKGLQKFAISLENLEDSLILFVVDLSRPWLALDSLQKWGSVVRDFVDKLRVPPETMRELEHRLTKQFQEYVEPGS 188 zebrafish
Q90828       113 DGDLYHKGLLKFAMEANSLKDTLIMLVVDMSRPWTAMDSLQKWASVVREHIDKLKIPPEEMKEMEQKLVRDFQEYVEPGE 192 chicken
6F1T_i       190 GC-QGSPQRRGPLTSGSDEENVALPLGDNVLTHNLGIPVLVVCTKCDAVSVLEKEHDYRDEHLDFIQSHLRRFCLQYGAA 268
Q16RB5       186 ELdPGSPIKRTNRLSSVDDDLDALPLPEGVLTTNLGLDVVVVVTKTDYMTTLEKELDYRDEHFDFMQQWIRRFCLVYGAS 265 yellow fever mo...
XP_015041575 187 DLdPGSPVKRTMRNNSIDED-DLLPLTEDALITNLGLDIVVVVTKTDYMTTLEKEYEYRDEHFDFIQQWIRSFCLRTGAS 265
Q6PDL0       190 GC-QGSPQRRGPLTSGSDEDSVALPLGDNVLTHNLGIPVLVVCTKCDAMSVLEKEHDYRDEHLDFIQAHLRRFCLQYGAA 268 house mouse
NP_001017669 186 AT-PGSPQRRAPAAAG-EDESVLLPLADNVLTHNLGIPMLIVCTKCDAVNVLEKEHDYKEEHFDFIQSHIRRFCLQYGAG 263
Q1LUM9       189 DL-DAVPQRRNPES---DEESVLLPLGENTLTHNLGLPIVVVCTKCDAISTLEKEHDYKDEHLDFIQSHIRRFCLQYGAA 264 zebrafish
Q90828       193 DF-PASPQRRNTSLQEDKDDSVILPLGADTLTCNLGIPVVVVCTKCDAISVLEKEHDYRDEHFDFIQSHIRRFCLQYGAA 271 chicken
6F1T_i       269 LIYTSVKEEKNLDLLYKYIVHKTYGFHFTTPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKL 348
Q16RB5       266 LFYTSVKEDKNCDLLYKYLTHRIYGLPFRTPALIVEKDAVLIPAGWDNMKKINILYENMQSCKPDDYYNDIIAQPPSRKT 345 yellow fever mo...
XP_015041575 266 LFYTSVKEDKNCDLLYKYLTHRIYGLPFRTPALVVEKDAVLIPAGWDSLKKISILYENMHGIKAESPYSDVIKAPPTRKA 345
Q6PDL0       269 LIYTSVKEEKNLDLLYKYIVHKTYGFHFTIPALVVEKDAVFIPAGWDNEKKIAILHENFTTVKPEDAYEDFIVKPPVRKL 348 house mouse
NP_001017669 264 LIYTSVKEEKNLDLLYKYMVHKIYDFQFSSPALVVEKDAVFIPSGWDNDKKICILHENFTTVRPEDPFEDFITKPPVRKL 343
Q1LUM9       265 LLYTSMKENKNLDLLYKYLVHRLYGFPFNSPAQVVEKDSVFIPSGWDNEKKIAILHENFQMVKAEDSFEDVIVKPPVRKF 344 zebrafish
Q90828       272 LIYTSVKENKNIDLVYKYIVQKLYGFPFNVPAVVVEKDAVFIPAGWDNDKKIGILHENFQTLKAEDSFEDSIRKPPVRKF 351 chicken
6F1T_i       349 VHDKEL--AAEDEQVFLMKQQSLLaKQPATPT-RAsESPARGPSGSprtqGRGGPASVPSSSPGTS-VKKPDPNIKNNAA 424
Q16RB5       346 VSNREIevQTEEEQAFLSRQLQLL-QQGQTPT-RG-ESPMRSQNSA----SKTSPRTPGSAGAQGS-PKKVDGKLNPGTP 417 yellow fever mo...
XP_015041575 346 VSNREVevQTEDEQTFLARQQEILkQAGQ--D-RG-ESPLRSQGGGgvggNKSVPRTPGSTG-QSS-PKKIDPKLTPATP 419
Q6PDL0       349 VHDKEL--AAEDEQVFLMKQQSLLaKQPATPT-RTsESPARGPSGSprtqGRGGPASVPSASPGTS-VKKPDPNIKNNAA 424 house mouse
NP_001017669 344 VHDKEI--SAEDEQVFLMKQQSLLaKQPATPT-RGtESPARTASGSprptGRTGPTNVASVSPMTA-VKKPDPNMKGAAA 419
Q1LUM9       345 VHEKEV--QAEDDQVFLVKLQSLLsKQPPVTAgRPvDPTNRAPTGSprttNRSAAANVANVMPMQSgTKKIDPNMKGGQT 422 zebrafish
Q90828       352 VHEKEI--VAEDDQVFLMKQQSQLaKQPPTAAgRPvDASPRVPGGSprtpNRSVTSNVASVTPIPAgSKKIDPNMKAGAT 429 chicken
6F1T_i       425 S-EGVLASFFNSLLSKKT--------------GSPGSPGAGGVQSTAKKSGQKTVLSNVQEELDRMTRKPDSMVt-NSST 488
Q16RB5       418 SgEGVLANFFNSLLHKKSgspaa-----aslaGTGVSPRATNGGDMVTASEKISMRTDAAMELDRLARSVKKDLd-FPAQ 491 yellow fever mo...
XP_015041575 420 GgEGVLANFFNSLLHKKSgspgggg-gppgagTPTGTTRTSNGTDSLMTPEKLAVRSDAAAELDRLSRSVKKEId-L-SQ 496
Q6PDL0       425 S-EGVLASFFNSLLSKKTgspg------spsaGG--------VQSTAKKSGQKTVLSNVQEELDRMTRKPDSMVt-NSSt 488 house mouse
NP_001017669 420 N-EGVLANFFNSLLSKKTgvpgs----pgtpgAGAGAGTGTGVQGSAKKTGQKPGLTDVQAELDRMTRKPDSLVt-ANNt 493
Q1LUM9       423 S-EGVLANFFNSLLTKKAgsp---------gpGGQPAGGGSNTPGTVRKSGSKLGLTDVQAELDRISNKSDLDSsaPNAT 492 zebrafish
Q90828       430 S-EGVLANFFNSLLSKKTgspggpggvggspgGGSAGGTGSNLPPSAKKSGQKPVLTDVQAELDRISRKPEMVS--PTSP 506 chicken
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