1KTZ


Conserved Protein Domain Family
TGF_beta_TGFB3
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cd19386: TGF_beta_TGFB3 
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins
TGF-beta-3 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development.
Links
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Statistics
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PSSM-Id: 381656
Aligned: 5 rows
Threshold Bit Score: 204.867
Created: 18-Jul-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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polypeptideputative
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:polypeptide substrate binding site [polypeptide binding site]
Evidence:
  • Structure:1KTZ; Homo sapiens TGF-B3 in complex with its receptor TbetaR2, contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     #     ## #                                                       ##
1KTZ_A        12 EENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY 91  human
P16047       312 EENCCVRPLYIELPTDLGWKWVHEPKGYFANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY 391 chicken
P10600       312 EENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY 391 human
XP_005986600 309 EDNCCVRPLYINFRQDLGWKWIYKPEGYFANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYY 388 coelacanth
NP_919367    310 EENCCVRKLYIDFRQDLGWRWIHEPKGYHANFCSGPCPYLRSADTTHSSLLSLYNTLNPEASASPCCVPQDLEPLTILYY 389 zebrafish

Feature 1        ###                  
1KTZ_A        92 VGRTPKVEQLSNMVVKSCKCS 112 human
P16047       392 VGRTPKVEQLSNMVVKSCKCS 412 chicken
P10600       392 VGRTPKVEQLSNMVVKSCKCS 412 human
XP_005986600 389 VGRTPKVEQLSNMIVKSCKCS 409 coelacanth
NP_919367    390 VGRTPKVEQLSNMIVKSCKCS 410 zebrafish

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