Conserved Protein Domain Family
Phage_GPO

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pfam05929: Phage_GPO 
Phage capsid scaffolding protein (GPO) serine peptidase
This family consists of several bacteriophage capsid scaffolding proteins (GPO) and some related bacterial sequences. GPO is thought to function in both the assembly of proheads and the cleavage of GPN. The family is found to function as a serine peptidase, with a conserved Asp, His and Ser catalytic triad, as in subtilisin, and as represented in MEROPS:S73. The family includes SwissProt:P25478 from Enterobacteria phage P2 which cleaves itself and then becomes the scaffold protein upon which the bacteriophage prohead is built - a mechanism quite common amongst phages.
Statistics
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PSSM-Id: 428677
Aligned: 20 rows
Threshold Bit Score: 313.111
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_024911027    5 TKMFCLAVEGDTTDGRAITKRDLLDIASSYNPA-LYGARVDLEHIK-AYSP---ESVFRAYGDVQApLKTETLA---DGP 76  Chania multitu...
CCH:MU9_2821    5 SKPVRICTEGATTDGRVIQRSWLTDIEKNYDPN-VYGARINLEHIKyEWMP--------RFGDVES-VYTEEIT---DGA 71 
Q8P6J6         10 SNWFRVAVEGATTDGRTIQRSWIDDMAATYNRE-TYGARIWIEHMR-SLLP---DSPFRAYGDVTA-VKAEEVEi--DG- 80  Xanthomonas ca...
hku:LHK_02583   5 SKAFRVATEGATTDGREIRREWIEQMARNYDPA-VFGARVNIDHIK-GILP---DSPFKRYGDVTA-LEAREVE------ 72 
WP_012621778    5 SNWFVVATEGATVDGRQIERQWLSDIAETYDPK-TYGARINLEHFHmSWFDp-eLAHSKCYGDVLA-VKAEEND------ 75  Glaesserella p...
Q19UY3          5 SKWFVVATEGATTDGREISREWLTQIEENYDPKnNYGARINLEHFRwRWFEk-dDPHSYSYGDVLA-VKTEERE------ 76  Mannheimia vir...
KFD04539        4 SKPFRVAVEGATCDGRTLERQHIVQMAQRFNPT-VYGARVNLEHLR-GYSP---NSDFRAYGDVIS-VKAEEIT---EEP 74 
ACR27349        6 TKFFRVAVEGATVDGREIKREWLTQMAKNYNRE-LYGARLNIEHLK-GWAPlsaTNPFGAYGDVIA-LKASEIE---DGP 79 
Q63YL6          5 TKFFRVAVEGATVDGREIKREWLTQMAKHYDPK-LYGARVNVEHIK-GWAPlsaNNPFGAYGDVIA-LKAAEIE---DGP 78  Burkholderia p...
CCA91327        4 SKFFRVAVEGATVDGRVIQREWLEQMAASYDPA-TYTARINCEHVA-GYSP---DRPFNAYGSVLS-LKTEEVElsfNGE 77 
WP_024911027   77 LKGKLALYGQIDATDDLVALNKKRQKVYPSIQFHPQFPQTGGAYLMGLALTDTPASLGTEMLEFCSRA-AINPLASRKHS 155 Chania multitu...
CCH:MU9_2821   72 LKGKLALYATLKPTADLIEMNKKRQKVYTSAEIAPKFADTGAAYLVGLAVTDNPASLGTQMLQFSQGA-GESPFADRKQS 150
Q8P6J6         81 -TKRLALFAQIEPTADLITINKSKQKLYTSIEVQEKFANTGKAYLVGLAVTDSPASLGTSMLSFASQNpDANPLADRKQS 159 Xanthomonas ca...
hku:LHK_02583  73 -DGKLALFATIDPTDELVALTRARQKIYTSIEVVEQFADSGEAYLVGLAVTDDPASLGTEMLQFCARA-GHNPLAGRKSQ 150
WP_012621778   76 -EGKLQLYAQIEPTDELVELVNSKQKVYTSIEVRTNFAKTGKAYLTGLAVTDTPASLGTQYLSFTTKN--------GEQQ 146 Glaesserella p...
Q19UY3         77 -DGKLQLLAEIAPTEALVKLVKDKQKVYTSVEIDLNFADTGEAYLVGLAVTDTPASLGTEYLTFCAGA-THNPLADRKQK 154 Mannheimia vir...
KFD04539       75 LKGKMGLYVQVDATDDLVALKKSRQKIYHSIEVHPSFADTGEAYLMGLACTDSPASLGTEMMEFCAKN-SVNPLSSRKHD 153
ACR27349       80 LKGKMGLYAQLDPTDELVALSKKRQKVFTSIEVNPDFADIGEAYLVGLAATDDPASLGTEALQFAARR------------ 147
Q63YL6         79 LKGKMALYAQIDPTDELVALSKKRQKLFTSIEINPDFADIGEAYLVGLAATDDPASLGTEALQFAAKR------------ 146 Burkholderia p...
CCA91327       78 KKSLLALYAEIDANDQLVEINKAGQKLFTSCEIHPDFAGEGKAYLVGLAVTDQPASLGTEPLKFAALS------------ 145
WP_024911027  156 PECLIAAVDEAmgfSIELEETEAPPAdtgmQFFNRIKGILTGNQQKT-------A------------------GDIGQIQ 210 Chania multitu...
CCH:MU9_2821  151 KDNVITLAEET---VIEFTEDKPDEPkv-pSLFTRITEVLTGKGKQD-------D------------------ARFHDVH 201
Q8P6J6        160 PGNLFTVAEET---ALEFSEVSEGPVa---NLLSRIRTALKSEDATSit-----------------------aEQFAELG 210 Xanthomonas ca...
hku:LHK_02583 151 PGSLFTAAVPV---ELEFVEATGPADag-kGLFATVMALLTGKGKTD-------D------------------ARFADHA 201
WP_012621778  147 GEIFTTEAVEC---SLTFAEEPv-------SFFEKMKAMFSKEKADTaqhkadvE------------------ARFAEHE 198 Glaesserella p...
Q19UY3        155 PENLVSEAVEA---NLEFTAEPEKGA-----WLEKFKAMFTKAKTDN-------D------------------GKFAEHE 201 Mannheimia vir...
KFD04539      154 QACFFTAAVES---TMEFEDEQPPQDeg-kNFFARIKALLGGTQQQF-------S------------------QQNGENR 204
ACR27349      148 SNNLFSAACET---LIEFDGEPESTS-----LLSIVKSMFARNRSTD-------D------------------QRDADVR 194
Q63YL6        147 SNNLYTPACET---AIEFEGAAETAG-----LKEWVKGLFARNREND-------D------------------ERFADVR 193 Burkholderia p...
CCA91327      146 RPNLFTTAHET---ALELAAQPLSGEqigeSIGRSLLAFFRKDRKEE-------EpatpppapapandnafdvDRFASVM 215
WP_024911027  211 QAVEQIALSQ-------KELLDGQTKLS---------AIETENAALKQSVAKLTADLSTLTES---LSSQPE-PGKKRQP 270 Chania multitu...
CCH:MU9_2821  202 QSVELIAKAV-------EAIQTDVAALKktslsdpepEEIAELAALKK-------ELTELKAQ---LSQQDN-SGHKRPV 263
Q8P6J6        211 EGVEEIAEHV-------RGQDERFN------------RLQAEHAEQKTKHEQLANDLAQLRES---LSQQPDpAQPARPV 268 Xanthomonas ca...
hku:LHK_02583 202 AAIEALAESQ-------QAVPTLQGAVR---------ALQHSGQSLDARLQSLTAELADLKTR---LDSQPQ-PGFTRQP 261
WP_012621778  199 QAQLLLAEKF-------TELEDKLK------------QTEAEKMALCADFEKLSADLTALQSRvdvIGSEPEhGYTPRPE 259 Glaesserella p...
Q19UY3        202 KAMELLAEQF-------SKVSTEND------------RLQTELSTLQIEFTELQKQAGEFAEKfakLEQEPSaNYTPRPK 262 Mannheimia vir...
KFD04539      205 EAIEAIAESQ-------GKLLDSTTQLSaav---kgkADATELESLRK-------DFKALEEK---LKGQDAeQYNQRPA 264
ACR27349      195 HAVEEIAGFVsqqgcdvAALRVDLT------------AAQQDAAAAKKRADEAVTAVEALTTK---LSATDN-GAPRRQL 258
Q63YL6        194 EALERVAIHAhhtgrevATLSTAVT------------SATGAAADAKKRADEAFAAVEALTEK---LSNTDN-GAPQRPP 257 Burkholderia p...
CCA91327      216 GL--QIAAAV-------KPANDAVAALGa--------------------------RFDALESK---LKATEQpGSFTRAP 257
WP_024911027  271 ATG----------SNT 276 Chania multitudinisentens
CCH:MU9_2821  264 SLGnngtqpeellTDC 279
Q8P6J6        269 VTGggv----avlTDC 280 Xanthomonas campestris pv. campestris
hku:LHK_02583 262 ATGgag----kteTDC 273
WP_012621778  260 ITG-----------GE 264 Glaesserella parasuis
Q19UY3        263 ATGakag---dvqTDf 275 Mannheimia virus PHL101
KFD04539      265 ATGgdgqs-tqhlADC 279
ACR27349      259 STGstg----elaTDC 270
Q63YL6        258 STGstg----elvTDC 269 Burkholderia pseudomallei
CCA91327      258 ATGgtg----sikTDC 269
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