2MA6


Conserved Protein Domain Family
RING-HC_RNF123
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cd16541: RING-HC_RNF123 
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RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins
RNF123, also known as Kip1 ubiquitination-promoting complex protein 1 (KPC1), is an E3 ubiquitin-protein ligase that mediates ubiquitination and proteasomal processing of the nuclear factor-kappaB 1 (NF-kappaB1) precursor p105 to the p50 active subunit that restricts tumor growth. It also regulates degradation of heterochromatin protein 1alpha (HP1alpha) and 1beta (HP1beta) in lamin A/C knock-down cells. Moreover, RNF123, together with Kip1 ubiquitylation-promoting complex 2 (KPC2), forms the Kip1 ubiquitination-promoting complex (KPC), acting as a cytoplasmic ubiquitin ligase that regulates degradation of the cyclin-dependent kinase inhibitor p27 (Kip1) at the G1 phase of the cell cycle. RNF123 may also function as a clinically relevant, peripheral state marker of depression. RNF123 contains a C3HC4-type RING-HC finger at the C-terminus.
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Statistics
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PSSM-Id: 438203
Aligned: 22 rows
Threshold Bit Score: 71.5632
Created: 28-Jan-2015
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:2MA6; Homo sapiens RNF123 binds two Zn2+ ions through its RING-HC finger.
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #           # #  #  #           #  #    
2MA6_A       9 DLCPICYAHPiSAVFQPCGHKSCKACINQHLMNn-KDCFFCKTTI 52   human
ELU17872  1127 DLCEICYAKQrDVSFQPCGHQSCRGCIQHYLMNk-NECFFCKAQV 1170 Capitella sp. I Grassle & Grassle, 1976
EDO45063  1093 ELCPICCAMRiSVRFLPCRHVSCRSCITRHLMNn-KECFFCKEVV 1136 starlet sea anemone
EFJ08108  1138 ELCSICYACEeNAVFLPCKHRSCVRCVSRHLLNn-QRCFFCNAAI 1181 Selaginella moellendorffii
EAL43917   972 QLCFICCSNPaDTIMLPCKHSACRSCIERHMEHh-NECFFCKTKI 1015 Entamoeba histolytica HM-1:IMSS
ELR14065  1173 ELCPICYADViNTTFLPCKHQSCKRCIQRHMLQs-KTCFFCKADV 1216 Acanthamoeba castellanii str. Neff
KFM72197  1142 LVCTICYANPkSARFHPCQHQSCRSCISLHLLSh-KECFFCKALI 1185 Stegodyphus mimosarum
Q9SIZ8    1215 NTCCICYAGEaNAMIAPCSHRSCYGCITRHLLNc-QRCFFCNATV 1258 thale cress
KNC85365  1542 DTCSICYTYPlSATFLPCRHQSCHQCITRHLLNs-KECFFCKELI 1585 Sphaeroforma arctica JP610
CUG75666   189 GTCLICMIRDaDTSFSPCGHVSCMDCINRHISSgsGKCFWCNVTV 233  Bodo saltans

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