Conserved Protein Domain Family
ATAD4

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pfam15321: ATAD4 
ATPase family AAA domain containing 4
ATAD4 is a family of proteins is found in eukaryotes. The family is also known as PRR15L, or proline-rich 15-like. ATAD4 is expressed almost exclusively in post-mitotic cells both during foetal development and in adult tissues, such as the intestinal epithelium and the testis. Its expression in mouse and human gastrointestinal tumours is linked, directly or indirectly, to the disruption of the Wnt signaling pathway.
Statistics
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PSSM-Id: 464644
Aligned: 34 rows
Threshold Bit Score: 60.5846
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEN54085      88 WWNrLL-GRKSRGDSKDRKdsrgsgagpyk--edsdaenrkpdELP-------NGRKSGSQTSksaqv------------ 145
EEN54086       6 WWGnLWgKSKSKKQYKKAFssg------------------appETEgedvddaQDGGKRRNGSwdnldagdldlqkvspt 67 
EHB15673      13 WWKsLTnSKKK---SKDAPvgvqppaqpv----pgepappspdWT-----------SSSQENQhpnvl------------ 62 
XP_008259807  13 WWKsLTnSRKK---SKEAAeaqppappal-----gepappspdWT-----------GGARENQhpnvl------------ 61 
XP_005205560  13 WWNsLTnSRKK---NKEATggaqppaqpa----pgepappvqdWT-----------SSSRENQhpsll------------ 62 
XP_003134861  13 WWNsLTnSRKK---SKDATvgaqppaqpa----pgeptppgpdWT-----------SGSRDNQhpnll------------ 62 
ELW67921      13 WWKsLTnSRKK---SKEVTagaqlpgqpapg--epvaasapspdT-----------SSSQENQhpnpl------------ 64 
XP_014342900  10 WWKsLT-LRKK---NKDVGlhqdggtd---------gqtatpdKSSpst--qaISSTTSQENKnpnf------------- 61 
XP_015212855   7 WWKsFT-LRKK---NKDPAatqyegnp---------elqttqdKTsm----gfTSSSDSRENQnqnl------------- 56 
XP_040044424   7 WWKaFL-PKKKSGGSKDTTssnafdadfdpfgsksaaskasgdQS----------LSQQESNKsssi------------- 62 
EEN54085     146 -------------rskcnPKLAESSNSELSKSQqSGPWRHHLSVSHSGRFKEKRKQRGTVSD 194
EEN54086      68 nnkdvsrtmqgrirskvnPHLADSS-NKIIRKSdSCPFRRNVGISNSGRFKE-HKYRMGVFD 127
EHB15673      63 -------------ggpgeSP----KSDKSCGEK-SGNSRRNLKISRSGRFKEKRKVRATLLP 106
XP_008259807  62 -------------ggagePQ----KPDKS-GDK-SGSSRRNLKVSRSGRFKEKRKVRATLLP 104
XP_005205560  63 -------------ggagePH----KLDKLGGEK-SGNSRRNLKISRSGRFKEKRKVRATLLP 106
XP_003134861  63 -------------ggageP-----KPDKSCGEK-SGNSRRNLKISRSGRFKEKRKVRATLLP 105
ELW67921      65 -------------ggagePH----KPDKACAEK-SANSRRNLKISRSGRFKEKRKARATMLP 108
XP_014342900  62 ---------------ineTEFADPRYERGFNEK---TCRRNLKISRSGRFKEKRRLRASLPD 105
XP_015212855  57 ---------------ikeQDYEDSNIEPVFNEK---TCRRNLKISRSGRFKEKSRVRATLPA 100
XP_040044424  63 ---------------vsdDTYDDSRLESVFNEQ---TCRRNMKVSRSGRFKEKRRVRSSLPI 106
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