Conserved Protein Domain Family
SH2_SH2D4B

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cd10351: SH2_SH2D4B 
Src homology 2 domain found in the SH2 domain containing protein 4B (SH2D4B)
SH2D4B contains a single SH2 domain. In general SH2 domains are involved in signal transduction. They typically bind pTyr-containing ligands via two surface pockets, a pTyr and hydrophobic binding pocket, allowing proteins with SH2 domains to localize to tyrosine phosphorylated sites.
Statistics
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PSSM-Id: 198214
Aligned: 6 rows
Threshold Bit Score: 202.427
Created: 31-May-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
phosphotyrosinehydrophobic
Feature 1:phosphotyrosine binding pocket [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       #                 #                   # #                        
Q5SQS7       317 RNTKFIAPWFHGIISREDAEALLENMTEGAFLVRVSEKIWGYTLSYRLQKGFKHFLVDASGDFYSFLGVDPNRHATLTDL 396 human
XP_689048    341 RSSNTIAPWFHGIISRQESEALLTNAVEGSFLVRVSERIWGYTLSYRNPSGFKHFLIDASGDHYNFLGVDQNRHATLADL 420 zebrafish
XP_003224130 716 RNSSTIAPWFHGIISRQEAEELLMNKSEGAFLVRVSEKIWGYALSYRHQSGFKHFLVDASGDFYSFLGVDPNRHATLTDL 795 green anole
XP_002933947 321 KNTEVVAQWFHGIISREEAEELLMNKPEGSFLVRVSDKIWGYALSFRQQTGFKHFLVDASGDYYSFLGVDPNRHATLTDL 400 western clawed ...
NP_808484    317 RNTKSIAPWFHGIISRESAEDLLENMTEGAFLVRVSEKIWGYTLSYRLQRGFKHFLVDASGDFYSFLGVDPNRHATLTDL 396 house mouse
XP_002664220 336 RNGKAIAPWFHGIISREDSETLLMNAAVGSFLVRVSERIWGYTLSYRTASGFKHFLIDASGDYYSFLGVDQNRHATLADL 415 zebrafish
Feature 1                                                            
Q5SQS7       397 VDFHKee-----------------------------iITVSGGELLQEPCGQ 419 human
XP_689048    421 INFHKee-----------------------------vITTSGGELLQDPCRP 443 zebrafish
XP_003224130 796 IDFHKee-----------------------------iITSSGGELLLEPCGQ 818 green anole
XP_002933947 401 IDFHKee-----------------------------vITSSGGELLVEPCGQ 423 western clawed frog
NP_808484    397 IDFHKee-----------------------------iITVSGGELLQEPCGQ 419 house mouse
XP_002664220 416 IDFHKpvvyqktsivvatvnsclnnvdsdsvdsqeeiITTTGKELLLEACTR 467 zebrafish

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