Conserved Protein Domain Family
SLC6sbd_GlyT2

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cd11499: SLC6sbd_GlyT2 
Na(+)- and Cl(-)-dependent glycine transporter GlyT2; solute-binding domain
GlyT2 (also called NET1) is a membrane-bound transporter that re-uptakes glycine from the synaptic cleft. Human GlyT2 is encoded by the SLC6A5 gene. GlyT2 is expressed in brain and spinal cord. GlyT2 may play a role in pain, and in spasticity. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.
Statistics
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PSSM-Id: 271389
Aligned: 3 rows
Threshold Bit Score: 1219.47
Created: 8-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
  next features
Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
Q9Y345       191 RGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQ 270 human
A7Y2X0       184 RGNWSNKLDFILSMVGYAVGLGNVWRFPYLAFKNGGGAFLIPYLTMLALAGLPIFYLEVALGQFASQGPISVWKAIPALQ 263 African clawed ...
NP_001009557 177 RGNWSNKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLIMLGLAGIPIFLLEVSLGQFASQGPVSVWKAIPALQ 256 zebrafish
Feature 1                                                                                #       
Q9Y345       271 GCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVISDHPKIQIKNSTFCMta 350 human
A7Y2X0       264 GCGIAMLIISVLIAIYYNIIMCYTIFYLFASLVYVLPWASCNNPWNTPDCKDKDRLLLDSCIISSQPNIQIKNSTFCMta 343 African clawed ...
NP_001009557 257 GCGIAMLIISVLIAIYYNIIMCWTLYYLFASLKETLPWATCKNEWNTVECKDKDMLLLDTCILRDRNITSIKNTTFCLs- 335 zebrafish
Feature 1                                                                                        
Q9Y345       351 ypNVtMVNFTs-----qANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKgIKTSGKVVYFT 425 human
A7Y2X0       344 ypNLtMVNFTs-----hGNKSFVSGSEEYFKYNMLKISAGIEYPGEIRWPLVFCLFLAWIIVYASLAKgIKTSGKVVYST 418 African clawed ...
NP_001009557 336 -aNV-VGNLSkllnvtvDNKTYVSPSEEYFKYNVLHISKGIEYPGDIRWPLAACLFLAWLIVYASLAKgIKSSGKVVYFT 413 zebrafish
Feature 1                                                                                        
Q9Y345       426 ATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWekltdatVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIV 505 human
A7Y2X0       419 ATFPYVVLVILLFRGVTLPGAGDGIWWFIMPKWeklmdatVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNLYRDTLIV 498 African clawed ...
NP_001009557 414 ATFPYVVLVILLIRGVTLPGAGSGILYFITPKWeklndakVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIV 493 zebrafish
Feature 1                                                                                        
Q9Y345       506 TCTNSATSIFAGFVIFSVIGFMANerKVNIENVADqgPGIAFVVYPEALTRLPlSPFWAIIFFLMLLTLGLDTMFATIET 585 human
A7Y2X0       499 TCINSATSIFAGFVIFSVIGFMAHilNVDIEKVADqgPGIAFVVYPEALTRLPlSPFWAIIFFLMLLTLGLDTMFATIET 578 African clawed ...
NP_001009557 494 TCTNSATSIFAGFVIFSVIGFMAHelKVPIESVADegPGIAFVVYPEALTRLPlSPFWAIIFFLMLLTLGLDTMFATIET 573 zebrafish
Feature 1                                                                                        
Q9Y345       586 IVTSISDEFPKYLRtHKPVFTLGCCICFFIMGFPMITQgGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDi 665 human
A7Y2X0       579 IVTSVSDEFPKLLRtHKPLFTLVCCVAFFIMGFPMITQgGIYMLQLVDNYAASYSLVIIAIFELVGISYIYGLQRFCEDi 658 African clawed ...
NP_001009557 574 IVTSVSDEFPKYLRkHKPQFTLVCCLSFFVLGFPMITEsGMYMLQLVDTFAASYSLVIIAIFELVGISYIYGLQRFCEDi 653 zebrafish
Feature 1                                                                                        
Q9Y345       666 emmIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSyRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGrFI 745 human
A7Y2X0       659 emmIGFQPSRFWKICWAFVTPTILTFILGFSFYQWEPMTYGSyHYPSWSMVMGWLMLACSVIWIPIMFVIKMFLAPGtFI 738 African clawed ...
NP_001009557 654 emmIGFQPNKFWRVCWAFVTPTILTFILALSLYQWKVMTYEDyTYPNWSMVLGWLMVICSVIWIPIMFAIKMHLAPGsLI 733 zebrafish
Feature 1                                                  
Q9Y345       746 ERLKLVCSPQpDWGPFLAQHRgERYKNMIDPLGTSSLGLKLP 787 human
A7Y2X0       739 ERLKLVCSPQpDWGPFLAKHRgERYKNMIDPLGTSSLGLKLP 780 African clawed frog
NP_001009557 734 ERLKLVCSPQpDWGPFLMKHRgERYKNMIDPLGTNSLGLKLP 775 zebrafish

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