3UAF


Conserved Protein Domain Family
TTR-52
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pfam01060: TTR-52 
Transthyretin-like family
TTR-52 was called family 2 in, and has weak similarity to transthyretin (formerly called pre-albumin) which transports thyroid hormones. The specific function of this protein is as a bridging molecule in apoptosis cross-linking dying cells to phagocytes. TTR-52 bridges by cross-linking surface-exposed phosphatidylserine (PtdSer) on apoptotic cells to the CED-1 receptor, a transmembrane receptor, on phagocytes. TTR-52 has an open beta-barrel-like structure.
Links
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Statistics
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PSSM-Id: 460046
Aligned: 95 rows
Threshold Bit Score: 66.0664
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3UAF_A         8 TGVLKCPTDPEavKKVHIDLWDAAAaaaesddlmgrtwsdrngnfqvtGCASDFgp-inTPDPYLYIQHNCPHr------ 80  Caenorhabditis ...
XP_003093615  29 RGRLVCNGKPF--KNEKVELYDKNKvkrdtrilttk--tdelgnfviqASINEWtf--fTPNPYIYFPNYCVLttki--g 100
CAP21497      28 RGKLMCNGKPY--VDGEISLYEKNWvgrdtklvatk--tdangnfvlkSSMSEWpl--fTPNPYIYFGNYCDInndl--g 99 
O17635        43 RGKLLCNGKPY--ENAEIELYEKNIigkdthlvttn--ttslgffsmkAAVSEWig--fSPNPYIHFANFCDPsnti--- 113 Caenorhabditis ...
EGT51656      25 RGRLMCNGQPF--TNEKVELYEKNWvrqdsrmasir--tdnngefsmqGAIEEWpl--fTPKPYIYIPNFCDIknkl--g 96 
EFP00673      24 TGRLMCGPSPY--RGEKVQIWDPNFligyslwsevs--tdesgyfsikGAGDDWs----GVNPFLWIPNYCGSstyv--- 92 
EGT49170      27 RGRLMCSSNPY--ANEKVQVWDPHFliefslwsetq--tdesgyfsmkASGNDWs----GVDPFIWIPNYCASslvg--- 95 
O01517        26 SGRLMCGGKPY--ANESVSIYEKNYmltdilmeslf------tdedgnfsvkTFgkdwpHFTPYLYAPNYCKPvdnfvfa 97  Caenorhabditis ...
CAP22185      28 RGILTCNGNAY--SKMPIETFEKNYifkddlltttt--tnddgsfyikYSGKDLv----FFNPYIYVPNYCLAetyn--- 96 
XP_003110632  28 SGSLSCHGRPY--SKMPVYIYEKNFlfedkllksak--tnddgsfyiqSSGEDLl----SFNPYVYVPNYCGAvrsp--- 96 

3UAF_A        81 ---DSNATNPIQID 91  Caenorhabditis elegans
XP_003093615 101 sfeCANG-IKIFVP 113
CAP21497     100 slqCADG-IKIFIP 112
O17635       114 rsmQCAKTIKIFIP 127 Caenorhabditis elegans
EGT51656      97 yfeCADS-VQIYVP 109
EFP00673      93 dkqCTEGLIQVNVP 106
EGT49170      96 dkrCTEGLIQLNVP 109
O01517        98 dreCTDSALQILIP 111 Caenorhabditis elegans
CAP22185      97 glkCTTGAMMIQIP 110
XP_003110632  97 dgiCTVKAMMVRIP 110
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