Conserved Protein Domain Family
E_Pc_C

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pfam06752: E_Pc_C 
Enhancer of Polycomb C-terminus
This family represents the C-terminus of eukaryotic enhancer of polycomb proteins, which have roles in heterochromatin formation. This family contains several conserved motifs.
Statistics
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PSSM-Id: 462002
Aligned: 18 rows
Threshold Bit Score: 176.57
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011606435 525 VLTAEQYQQHQEQLVLMQK-QLEQSqFQANnptttikttipttTNNTPTTT-QALVSKTLDQASAQFAASALVTTDQLLA 602
XP_015214102 573 GITEEEFHTHQQQLVQMQKqQLAQLqQKQQsqhss---hpehhTIQVSGTS--DCMSKTLDSASAQFAASAVVTAPGPGC 647
Q8C0I4       578 GITEEQFQTHQQQLVQMQRqQLAQLhQKQQsqhss---qqthpKAQGSSTS--DCMSKTLDSASAHFAASAVVSAPVPSR 652 house mouse
XP_006003852 575 GITEEQFQTHQQQLVQMQKqQLAQFqQKQQsqhsa---qqahqNSQGSRTL--DYVSKTLDSASAQFAASAVVSAPGPGR 649
AAI33737     575 AFTAEQYQQHQEQLVLMQKqQLEQVqQHQQt-----------gSSAVTNNP-QSLVSKTIDAASAQFAASALVTHEQLLA 642
XP_695062    579 AFTAEQYQQHQEQLALMQKqQLEQIqHQAN--------------NSASS---QSLVSKTLDSVSAQFAASALMTSDQLLT 641
XP_007259736 569 VFTAEQYQEHQEQLALMQKqQLEQIqQQA---------------SDASNNT-QSFVSKTLDSASAQFAASALVTSDQLLT 632
XP_003975952 601 AYTYEQYQQHQEQLSLMHKqQLEQVqLQQVg------------sSTTTNAShQSL-AHTLDQAKAQFAASALITVDQLLA 667
XP_023190923 522 AFTAEQYQQHQEQLSLMHKqQLEQIqQQHQa------------nSTANSTQ---SLANTLDEVSAHFAASALVSAEQLLA 586 southern platyfish
XP_031610256 533 AFTVEQYQQHQEQLSLMHKqQLEQVqQQQAn------------sATTANST-QTL-ANTLDQASAQFAASALVTADQLLA 598 Oreochromis aureus
XP_011606435 603 FKSKED--LVVTSGLNGVLTGAGAYKGHHLPTTTNLHQVNQt-THTTTsAVPAFLQPSPNSTspspatvvpsslssTPSA 679
XP_015214102 648 SEASKDn-RLHSISVNGVVQTSGTSKTLHSTSTTL--------STTPAiSSVQLL---------------------RTVP 697
Q8C0I4       653 SEGSKEqnTGHN-NMNGVVQPSGPSKTLYSTNMAL--------SSSPGiSAVQLV---------------------RTVG 702 house mouse
XP_006003852 650 IEVTKDngSGHSNNLNGVIQPSGTSKTLHSTNTTL--------SLSPAvSSVQLL---------------------RTVA 700
AAI33737     643 LKSKDE-----GVGVNGVVSASGVYKGLHHTSSAVSSILPSvgSTSTScPSPTIATTTNNGT--------------SSAN 703
XP_695062    642 LKVKED---GAGGGVNGVIQASGVYKGLSISSTSSSALITS--QSAPTaAPPTFLSSSSNSNts-----------sTHSV 705
XP_007259736 633 LKVKED--GVLGSGVNGILQASGVYKGLQLSATSSASILPS--PSPVMtSPPPILPPTNSNSltt---------gsVHNA 699
XP_003975952 668 LKTKEE--FGPGGGVNGVLSPSGVYKGLHLASTASPSPAAA--APPITtPTPMTLHPCTTTSs------------aSSTS 731
XP_023190923 587 LKTKDE--LVLGGGVNGVLSS-GVYKGLSLSSTASPSPAAP--APPSAtPTSALLHPCSTALg------------sATSN 649 southern platyfish
XP_031610256 599 LKTKEE----LGPGVNGVLSPSGVYKGLHLLSTASPSPATP--APPTAtTTPASLHPCTTSSt------------sATSN 660 Oreochromis aureus
XP_011606435 680 HSAAALgilgcgTTNNSTSSSTQVLIG---NNICLSVPTAT-------SLAGRHIPRTLG-NVPs-SALKL--SATANLQ 745
XP_015214102 698 HSSTSH------LIPALCTSTPQSLPG---NSSCLATAVHLsnvsvvsPVNMHLSTRT---SAPspSALKLatVATPLDR 765
Q8C0I4       703 HTTTNH------LIPALCTSSPQTLPM---NNSCLTNAVHLnnvsvvsPVNVHINTRT---SAPspTALKLatVAASMDR 770 house mouse
XP_006003852 701 HPNANH------LIPTLCTTSPQTLPM---SNSCLNNAVHLnnvgvisPINVPPNARS---SAPspAALKLatVATSLER 768
AAI33737     704 H-----------HVGPAGPAPGQALMG---GAVRVSVPSPAg------TLSVRQLQRQL--TVPa-SALKL--AANANRP 758
XP_695062    706 HTPIGN------HGNSTANSASQVLIG---NNLRLSVTAPSi-----aSLNARHLPRSLS-NVPp-AALKL---AASNCQ 766
XP_007259736 700 HNPLSN------HGNNTANAVPQVLIG---NNLRLSVATPQ---------IARHLPRSLG-GVPp-AALKLa-AAASNCQ 758
XP_003975952 732 NNGTAHp----tNTTITTATTTQVLLGn--NSLRLGVPTGK----------RVHAPRTLSsSVSt-SALKLahAATANCQ 794
XP_023190923 650 NNGTAH------P----PANATQILLGn--NSLRLAIPTSK----------RIHAPRTLStTMSt-SALKLahAATANCQ 706 southern platyfish
XP_031610256 661 NNGTTHp-----ANTTTTNATTQVLLGnnnNSLRLSVPATK----------RVPTPRTLStTMSt-SALKLahAAAANCQ 724 Oreochromis aureus
XP_011606435 746 MPKV--SGASSVDLGSRDNRDEDKPALNSIADNTVAMEVT 783
XP_015214102 766 VPKV--TPSSAISSIARESHEPERLALNGISETTVAMEVT 803
Q8C0I4       771 VPKV--TPSSAISSIARENHEPERLGLNGLAETTVAMEVT 808 house mouse
XP_006003852 769 VSKV--TPSSAISSMARENHEPERLALNGITETTVAMEAT 806
AAI33737     759 LPKVt-TGSTTLDMGPRENHDQEKPPLNSLTENTVAMEVT 797
XP_695062    767 LPKA----------NAGEKHEQEKQSLNSLAENTVAMEVT 796
XP_007259736 759 LPKV----------TPGENREPEKQSL-SLAENTVAMEVT 787
XP_003975952 795 KPKV--ANATPLDIVPRENHEQDKPALNSLSENTMAMEVT 832
XP_023190923 707 KPKVaaSSTSPLDKVPRENLEQDKPALNSLSENTVAMEVT 746 southern platyfish
XP_031610256 725 KPKVttASASPLDIVPRENHEQDKPALNSLTENTVAMEVT 764 Oreochromis aureus
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