1V73,2Z72,2ZBM


Conserved Protein Domain Family
MPP_Shelphs

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cd07425: MPP_Shelphs 
Click on image for an interactive view with Cn3D
Shewanella-like phosphatases, metallophosphatase domain
This family includes bacterial, eukaryotic, and archeal proteins orthologous to the Shewanella cold-active protein-tyrosine phosphatase, CAPTPase. CAPTPase is an uncharacterized protein that belongs to the Shelph (Shewanella-like phosphatase) family of PPP (phosphoprotein phosphatases). The PPP family is one of two known protein phosphatase families specific for serine and threonine. In addition to Shelps, the PPP family also includes: PP1, PP2A, PP2B (calcineurin), PP4, PP5, PP6, PP7, Bsu1, RdgC, PrpE, PrpA/PrpB, and ApA4 hydrolase. The PPP catalytic domain is defined by three conserved motifs (-GDXHG-, -GDXVDRG- and -GNHE-). The PPP enzyme family is ancient with members found in all eukaryotes, and in most bacterial and archeal genomes. Dephosphorylation of phosphoserines and phosphothreonines on target proteins plays a central role in the regulation of many cellular processes. PPPs belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination.
Statistics
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PSSM-Id: 277368
Aligned: 17 rows
Threshold Bit Score: 231.804
Created: 27-Jul-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitemetal binding
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1V73_A; Shewanella CAPTPase binds two Ca2+ ions and acetic acid.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            # #                                     #   #                               
1V73_A        74 VALSDVHGQYDVLLTLLKKQKIids----dgnWAFGEGHMVMTGDIFDRGhqVNEVLWFMYQLDQQArd-aGGMVHLLMG 148 Shewanella sp.
2Z72_A        74 VALSDVHGQYDVLLTLLKKQKIids----dgnWAFGEGHMVMTGDIFDRGhqVNEVLWFMYQLDQQArd-aGGMVHLLMG 148 Shewanella sp.
2ZBM_A        74 VALSDVHGQYDVLLTLLKKQKIids----dgnWAFGEGHMVMTGDMFDRGhqVNEVLWFMYQLDQQArd-aGGMVHLLMG 148 Shewanella sp.
Q7RR22        38 YSIGDLHGDKDAFIRILLNESIidi----enkVIRNNVLTVITGDVLDPTy-DDIDIILFIKNYNESgkslNSKIILLLG 112 Plasmodium yoel...
XP_001879172  90 VAVGDLHGDLPNARKVLQFSGItds----ngdWTGDVDFFVQTGDIIDRGddTIPLFFWMDKLRSQAaa-vGGTVLSHLG 164 Laccaria bicolo...
Q8IKE5        59 IAIGDIHGDVESLKLILRHSNLide----ndeWIAEDVMLVQVGDILDRGvfGTYIYDYLLKLQKDAik-kNSKVILIMG 133 Plasmodium falc...
XP_625492     89 LVIGDIHGDLKSLITSLFLSGVins----nldWIAKNTLLIQLGDVVDRGshALQIYKLFNKLKSQAps-lGSKFVGLLG 163 Cryptosporidium...
XP_818832     35 VAFGDIHGDVFRCRQILQLANItdt----edrWIAGSSIVVQLGDIADRGlhPHEIYDLFASLERQAmr-aGGEFIFLVG 109 Trypanosoma cru...
XP_001691994 105 IAIGDLHGDLDKAVEALKLGRVisvsdegevsWVGGDTVVVQLGDVLDRGdvEIGIINLLRYLDTEArk-qGGAVYMLNG 183 Chlamydomonas r...
XP_845580     26 VVVGDLHGDLNQTLAILKITGLvdd----rqhWIGGDSFFVQLGDIFDVGpdDISIVKLLMKLEKEAqs-vGGDVIELLG 100 Trypanosoma bru...
Feature 1        ##                                                                              
1V73_A       149 NHEqmvlgGDLRYVhqrydiattlin-------------------------------------------rpynklygadt 185 Shewanella sp.
2Z72_A       149 NHEqmvlgGDLRYVhqrydiattlin-------------------------------------------rpynklysadt 185 Shewanella sp.
2ZBM_A       149 NHEqmvlgGDLRYVhqrydiattlin-------------------------------------------rpynklygadt 185 Shewanella sp.
Q7RR22       113 NHEvnnlcLKFKTPqsnienykyr------------------------------------------------ndmfrkgg 144 Plasmodium yoel...
XP_001879172 165 NHEwmnviGDWRYVypteiktfgsvsarqqmlttgrigrswaanyttasrlplhaylgppntpyppksmkihyekdsdge 244 Laccaria bicolo...
Q8IKE5       134 NHEqlnlcGAFHYVnesevmlffqnnr-----------------------------------------nnrlfsftnkng 172 Plasmodium falc...
XP_625492    164 NHEvmnlcGQLHYVtdedfqtyggrd--------------------------------------------nrtfewskeg 199 Cryptosporidium...
XP_818832    110 NHElmnilGIFYYVhpdvmsafggee--------------------------------------------ayaaafgpeg 145 Trypanosoma cru...
XP_001691994 184 NHEslnvcGDFRYVtpgafaesalyaglsesdl-----------------------------kdwqlvakvryslykpgg 234 Chlamydomonas r...
XP_845580    101 NHEirnllGDYSAVdpgslagsggvs--------------------------------------------grdrllsnrt 136 Trypanosoma bru...
Feature 1                             #                                                          
1V73_A       186 eIGQWLRSKNTIIKINDVLYMHGGIssewisreltldkanalyran---------------vdaskkslkaddllnflff 250 Shewanella sp.
2Z72_A       186 eIGQWLRSKNTIIKINDVLYMHGGIssewisreltldkanalyran---------------vdaskkslkaddllnflff 250 Shewanella sp.
2ZBM_A       186 eIGQWLRSKNTIIKINDVLYMHGGIssewisreltldkanalyran---------------vdaskkslkaddllnflff 250 Shewanella sp.
Q7RR22       145 tIYNYLIDSPFVVNVNNIIFSHAGVlpfystygidfineegkkeiin--------------ncellnqklqnqqelciac 210 Plasmodium yoel...
XP_001879172 245 lDPSYYYDSSKPLSHSAISFVHGGLsptyteltpfpsrinqisdsllaklqrrqpppphppnqypglplsttqeeerlyd 324 Laccaria bicolo...
Q8IKE5       173 yYFKKLIRLPVIVKINNIIFTHGGIskhmseydintinlktrlq-------------------ienkckmfqfekynyls 233 Plasmodium falc...
XP_625492    200 fVGKYLRTMKLAIRVNDSLYVHAGLlpkyaklgldkldklsnd---------------------llegdfcdfysslffv 258 Cryptosporidium...
XP_818832    146 pYGLYILQHPVTVVREGVVFAHAGItpeyaargvesinaelmngfrg-------------erdlllegdakgdgvhtlsn 212 Trypanosoma cru...
XP_001691994 235 dLAREFSRNPTVLVVNDTVFAHGGLlpthveygierlnsevaawmr---------------gddipdgnkaqppflamgd 299 Chlamydomonas r...
XP_845580    137 sVGMYLRTRKAIFHHNEFLFMHGGLstatasiitgidkihefnkdlrkal--------tngtltplgstglnlaegggqe 208 Trypanosoma bru...
Feature 1             # #                                       #                                
1V73_A       251 gnGPTWYRgyfsetfteae------------ldtilqhfnvnHIVVGHTSqervlg----lfhnkVIAVDSSik--vGKS 312 Shewanella sp.
2Z72_A       251 gnGPTWYRgyfsetfteae------------ldtilqhfnvnHIVVGHTSqervlg----lfhnkVIAVDSSik--vGKS 312 Shewanella sp.
2ZBM_A       251 gnGPTWYRgyfsetfteae------------ldtilqhfnvnHIVVGHTSqervlg----lfhnkVIAVDSSik--vGKS 312 Shewanella sp.
Q7RR22       211 eyGPTLNRyysyvtknvfseskv-----csslykslgllksnRMVIGHTVqrnkqvn--sfcqdkLLLADTGis--kWKN 281 Plasmodium yoel...
XP_001879172 325 gnGPLWYRgwatdpdkkvca----------dvdrvlaktgtrRMIMGHTPdfknik---arcggkIIIIDTGi---sHAY 388 Laccaria bicolo...
Q8IKE5       234 keGVLWNNeishqvklqpkktc-------khlrnilkkynakGLVVGHTRqksheiq--tycnnsFFLIDTGms--lFMN 302 Plasmodium falc...
XP_625492    259 edGPLWTRdislgeeekack----------lvdetlqilglsRMVVGHTIqhdnrin--ikcdnkLILADTGfs--eAIY 324 Cryptosporidium...
XP_818832    213 ssSPLWSRavldeakrgncsllmeslrllsahelasgrppvrVMVGGHTVqeggvma--vecngsLVGADVGlsrffSSY 290 Trypanosoma cru...
XP_001691994 300 anSVMWNRtlskerfatpyeryh----acnalkqalakvrgkRLVVGHTPqlggvn---cecenqVWRIDVGms--yGVL 370 Chlamydomonas r...
XP_845580    209 vvNPILVRsilnvrckdli------------kvlqnkfagikSVVVGHVPhnhqdfkdwrlcgghLIAIDFGls--rWKK 274 Trypanosoma bru...
Feature 1              
1V73_A       313 GELLLL 318 Shewanella sp.
2Z72_A       313 GELLLL 318 Shewanella sp.
2ZBM_A       313 GELLLL 318 Shewanella sp.
Q7RR22       282 GVISYI 287 Plasmodium yoelii yoelii
XP_001879172 389 GGALSA 394 Laccaria bicolor S238N-H82
Q8IKE5       303 NGQPYP 308 Plasmodium falciparum 3D7
XP_625492    325 GKPCML 330 Cryptosporidium parvum Iowa II
XP_818832    291 GGYVAY 296 Trypanosoma cruzi strain CL Brener
XP_001691994 371 NRPVQV 376 Chlamydomonas reinhardtii
XP_845580    275 GDPGHV 280 Trypanosoma brucei TREU927

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