5J3Q


Conserved Protein Domain Family
DCP1

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pfam06058: DCP1 
Dcp1-like decapping family
An essential step in mRNA turnover is decapping. In yeast, two proteins have been identified that are essential for decapping, Dcp1 (this family) and Dcp2 (pfam05026). The precise role of these proteins in the decapping reaction have not been established. Evidence suggests that the Dcp1 may enhance the function of Dcp2.
Statistics
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PSSM-Id: 461816
Aligned: 70 rows
Threshold Bit Score: 79.1359
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5J3Q_A        11 RNAVNLQVLKF--HYPE-IESIIDIASHVAVYQFDVGSQKWLKTSIEGTFF--LVKD-----QR-ARVGYVILN--RNSP 77  fission yeast
Q4U8T6        27 RGRLSLKLLMT--LDPY-IETILHQTPFVTGYHMTS-QDKWSRMGIEGFLY--VVTR-----TKsPKHSFILVN--KKSE 93  Theileria annulata
4_pfamImport   1 LAAKNLAQLQK--IDIA-ASKILDKMPFAAIYKYDTAKSNWVKSVIEGTLF--IYQR-----ADrPYFSFLIAN--RNDP 68 
Q9N363        12 LAAKNLAQLQK--IDIA-ASKILDKMPFAAIYHIDAARKEWNQSNCEGTFF--VYQR-----ADrPYFSFLIAN--RNDP 79  Caenorhabditis ...
XP_001583636  16 RKDTNLRVIRKifQEVGyIQDYLNVYPEVCIYKKSE-DGRWVKLQIGGPLFlcVVQNq-------TDLTLFLLNntQTNE 87 
A0E4X8         3 RDQLNFSYLKR--LFPN-LEQILYTGKFTSLNEFDKCTQLWHQAGFQGPFF--LIKLt-------DQCVFIILN--QNST 68  Paramecium tetr...
EIJ87698       8 TNEVTNRMLKG--KDAQ-YSHLLLTSINVLVLKY---ENKWINTCTEGAIH--LYKR-----KIiPSTCILVLN--RKAP 72 
XP_007604018  22 QRKIVDRYLLS--IDNL-YSKLVFTTGKVILYIFE--NNEWIEMNLEGPLY--LYRRnneenVS-SQYRLIVLS--RNNM 91 
ELA46446       7 QSSILQRVLQR--YDPS-FHSTIYTSSHVALYKY---TTKWDRTSTEGNII--IYRR-----TTlPSTKLVIFN--KKDR 71 
Q8SU45         6 DGQILMREIGR--ADPL-LKDLLYVSSFASVYRH--ANGEWNKLNIEGTFV--MYTR-----ALcPPVGIHVFN--RKSL 71  Encephalitozoon...
5J3Q_A        78 E-NLYLFINHP-SNVHLVDR----YLIHRTENQ------HVVGLWMFDPNDMSRIFNIVKE 126 fission yeast
Q4U8T6        94 N-HLIEYLTPE-FQMNSSGN----FIFYRSLDItknflnNLQGLWFFDENECKTTYEKLGE 148 Theileria annulata
4_pfamImport  69 S-DFIEPLTTN-HVIRQEGN----YILFHKEVA------TIQALWFHQINDSNRASALLQK 117
Q9N363        80 S-DFIEPLTLN-HILRHDGN----FIYFYKDLA------SIQALWFHQIDDAQKIYNLLQK 128 Caenorhabditis elegans
XP_001583636  88 EsSFYKKLNPQ-TRYAIQGN----QLYIKTDQEs----dMVYS--FHDERDVQDLISKLRD 137
A0E4X8        69 Q-DFIRTIRKG-LTFELNKGtqwfYFNFQDEQQ------KVFNIWFQEQQDFENFKVCLER 121 Paramecium tetraurelia
EIJ87698      73 A-DFHLLIDKAvHGIEIFDR----FIIIKIAHKke---iEVFGLWFYDKQSCAQAGSILTD 125
XP_007604018  92 Q-DFKLNIPNS-FYLECQNQ----AVVFSHLDKn-----NIFGFWFDNELVVKKFYQVLQH 141
ELA46446      72 G-VFEVYLGG--IEVDMVRD----IIVFKNEA-------FCYGIWMVVEREREVLVEVVKR 118
Q8SU45        72 K-DFTLYLTKD-IRFGVKGN----FMTLSDDESg-----EVYGLWLHSDAHPGEVLRCLEE 121 Encephalitozoon cuniculi
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