Conserved Protein Domain Family
bHLH_TS_dMYOD_like

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cd19699: bHLH_TS_dMYOD_like 
basic helix-loop-helix (bHLH) domain found in Drosophila melanogaster myogenic-determination protein (dMYOD) and similar proteins
dMYOD, also termed protein nautilus, or Myd, may play an important role in the early development of muscle in Drosophila.
Statistics
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PSSM-Id: 381542
Aligned: 12 rows
Threshold Bit Score: 99.5361
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ##   # ### #    #                ####                  
P22816       161 DRRKAATMRERRRLRKVNEAFEILKRRTSsNPNQRLPKVEILRNAIEYIESLEDLL 216 fruit fly
Q17295       160 DRRKAATMRERRRLRKVNEAFEVVKQRTCpNPNQRLPKVEILRSAIDYINTLERML 215 Caenorhabditis briggsae
Q00492       112 DKRKAATLRERRRLRKVNEAFEALKRHTCaNPNQRLPKVEILRNAIEYIEKLERLL 167 green sea urchin
NP_001158428 105 DKRKAATMRERRRLKKVNEAFELLKRHTSaNPNQRLPKVEILRNAIEYIVRLEKLL 160 Saccoglossus kowalevskii
ESN92213     433 DRRKAATMRERRRLKRVNEAFEALKRRTCpNPAQRMAKVEILKSTIDYIENLEELV 488 Helobdella robusta
CCD59625     588 DRRKAATMRERRRLRKVNEAFETLKKRTCaNPNQRMPKVEILRNAIDYIENLEDML 643 Schistosoma mansoni
KOF94098      53 DRRKAATLRERRRLRKVNEAFETLKRRTCpNPNQRLPKVEILRNAIEYIESLEELL 108 Octopus bimaculoides
KZS21054     222 DRRKAATMRERRRLRKVNEAFESLKRRTSnNPGQRLPKVEILRNAIEYIESLEDML 277 Daphnia magna
AJV21316     191 DRRKAATMRERRRLRKVNEAFEVLKRRTCpNPNQRLPKVEILRNAIEYIESLEHLL 246 Terebratalia transversa
EEN60833      79 DRRKAATMRERRRLRKVNEAFEVLKRRTCtNPNQRLPKVEILRNAITYIESLENLL 134 Florida lancelet
EEC11614      71 DRRRAATLRERRRLHRVNEAFEVLKRRSCaNPAQRLPKVEILRSAIEYIEGLEDLL 126 black-legged tick
XP_023344683  36 DRRHAATMRERKRLRKVNEAFEILRQHTSnSPNQRLPKVEILRNAICYIESLETLL 91  Eurytemora affinis

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