Conserved Protein Domain Family
GCK

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pfam07802: GCK 
GCK domain
This domain is found in proteins carrying other domains known to be involved in intracellular signalling pathways (such as pfam00071) indicating that it might also be involved in these pathways. It has 4 highly conserved cysteine residues, suggesting that it can bind zinc ions. Moreover, it is found repeated in some members of this family; this may indicate that these domains are able to interact with one another, raising the possibility that this domain mediates heterodimerization.
Statistics
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PSSM-Id: 429666
Aligned: 27 rows
Threshold Bit Score: 72.3636
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9LZL1        76 EDQKFVEFMKGGGCKESFTAWnDDCNfteEEAEK-NK---DLVTKCAGLFGTFSKCMDTHSDY--YHPILAVKKTTEEHL 149 thale cress
XP_033138151  53 EECSFCTYIKAGECKESWIEL-EKCL---DEAKKkDGe--SDVTKCKEARKMFKTCIYDNPVH--YEPVIAAETYMFAKM 124
Q9FKK9        82 GECPLCQFIKGGECKEAFTEL-ENCC---DEAKK-NNe--DHVSKCKEARLIFKTCMYDNPVY--YEPLLAGEARAMAKM 152 thale cress
Q9FKL7        51 GECRLCRFIKGGECKESFIAL-EQCV---DEAEEsGEe--SDFTKCKEVRAKFKTCMYENPVY--YEPILAGEARAIAKM 122 thale cress
EFH68962     104 kakqVSEFMRD-PCRESIRSF-RR-----RDAEYtRNnntLTFHRKLEAFDTVYKCMEAHSDYnqYQAFLASMKRRYEYY 176
XP_020869049  74 ieLRVSEFMIKGACKESFTAL-KDCV---DEAK-------SHPKKCDEFFPRLNKCMHAHSDY--YQPILALVKASEEMM 140
XP_002890572 104 RDEMFTKFMIRGDCKEAFMAW-NDFC---KEAKKnNKs--CLHTPTMD---TLFKCMKAHSDY--YHPLLTVFKNAEEHF 172
XP_002890575 102 rDELLGKFITRGGCKEAFMAW-RDSY---EEAKK-NKg--SLYTPALN---TLSKCMEAHSDY--YQPLLAVVKNYEEHY 169
EFH66220     121 lEEKVLAFMKGGGCEEQCTAW-RDCF---EEAEK-NKe--DVDIKCAGVHAMWFNCMDAHSDY--FHPFLAPLKTAGEDF 191
EFH69043     178 EEERLLAMLKGGGCKESFMAW-LDCS---EEAEK-NKq--DFITKCAGVSAKLDKCLDAHSEY--YQPYFAVVKTAEEHM 248
Q9LZL1       150 EKE 152 thale cress
XP_033138151 125 LSD 127
Q9FKK9       153 LSE 155 thale cress
Q9FKL7       123 LNG 125 thale cress
EFH68962     177 DKE 179
XP_020869049 141 KKE 143
XP_002890572 173 KKE 175
XP_002890575 170 SKE 172
EFH66220     192 EKK 194
EFH69043     249 ENE 251
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