1PEM


Conserved Protein Domain Family
RNR_1b_NrdE
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TIGR04170: RNR_1b_NrdE 
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ribonucleoside-diphosphate reductase, class 1b, alpha subunit
Members of this family are NrdE, the alpha subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron.
Links
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Statistics
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PSSM-Id: 211905
Aligned: 7 rows
Threshold Bit Score: 1169.53
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1PEM_A        15 DYHALNAMLNLYDKAGHIQFDKDQQAIDAFFATHVRPHSVTFASQHERLGTLVREGYYDDAVLARYDRAFVLRLFEHAHA 94  Salmonella ente...
WP_011075917  22 DFHALNALLNLYDDDGKIQFDKDREAANQYFLQHVNQNTVFFHNLHEKLDYLVENNYYEKEVLDKYDFEYIKDLFKRAYS 101 Corynebacterium...
WP_011579166   2 DYHALNAMLNLYDSAGRIQFDKDSQAVDAFMTTHVRPNSVAFSSQQQRLNWLVNEGYYDESVLNRYSRDFVITLFAHAHA 81  Escherichia coli
WP_000523249  10 TYFRLNNEIN-RPVNGQIMLHKDKEALDAFFKENVVPNTMVFDSIKDKINYLIEHNYIETAFIKKYRPEFLEELAQFIKD 88  Streptococcus
WP_003245700   8 KWIQLNNEIMIQKD-GKFQFDKDKEAVHSYFVDYINQNTVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYA 86  Bacillus subtilis
WP_001829582  10 NHIELNNEVTKRKDNGFFDLEKDQEAL-KVYLEEIHDKMISFDDEIERLHYLVDNNFYFN-VFEKYSEAELIEITEYAKS 87  Staphylococcus
WP_002969365  39 DYHALNAMLNLYDEDGKIQLDCDRQAARQYFLQHVNQNTVFFHNLREKLDYLVAEGYYEQTVLDQYSFNFVRDLFDEAYA 118 Brucella

1PEM_A        95 SGFRFQTFLGAWKFYTSYTLKTFDGKRYLEHFEDRVTMVALTLAQGDETLATQLTDEMLSGRFQPATPTFLNCGKQQRGE 174 Salmonella ente...
WP_011075917 102 YKFRFKSFLGAYKYYTSYTLKTFDGRRYLERFEDRVCMVALTLADGDRETANALVDEIMTGRFQPATPTFLNSGKAQRGE 181 Corynebacterium...
WP_011579166  82 SGFRFQTFLGAWKFYTSYTLKTFDGKRYLEDFADRVTMVALTLAQGDETLAAQLTDEMLSGRFQPATPTFLNCGKQQRGE 161 Escherichia coli
WP_000523249  89 QNFQFKSFMAAYKFYNQYALKTNDGEYYLENMEDRVFFNALYFADGNEAVAIDIANEIIHQRYQPATPSFLNAGRARRGE 168 Streptococcus
WP_003245700  87 KKFRFPSFMSAFKFYNDYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAGRKRRGE 166 Bacillus subtilis
WP_001829582  88 IHFQFASYMSASKFYKDYALKTNDKTKFLEDYNQHVAIVALYLANGNVKQAKQFISAMVEQRYQPATPTFLNAGRARRGE 167 Staphylococcus
WP_002969365 119 RKFRFPTFLGAFKYYTSYTLKTFDGKRYLERYEDRVCMVALTLARGDEQLARDLVEEIISGRYQPATPTFLNAGKKQRGE 198 Brucella

1PEM_A       175 LVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGA 254 Salmonella ente...
WP_011075917 182 PVSCFLLRIEDNMESIGRAINSALQLSKRGGGVALLLSNLREAGAPIKKIENQSSGVIPVMKLLEDAFSYANQLGARQGA 261 Corynebacterium...
WP_011579166 162 LVSCFLLRIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVIPVMKMLEDAFSYANQLGARQGA 241 Escherichia coli
WP_000523249 169 LVSCFLIQVTDDMNSIGRSINSALQLSRIGGGVGITLSNLREAGAPIKGYEGAASGVVPVMKLFEDSFSYSNQLGQRQGA 248 Streptococcus
WP_003245700 167 LVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVENATKGVVGVMKLLDNAFRYADQMGQRQGS 246 Bacillus subtilis
WP_001829582 168 LVSCFLLEVDDSLNSINFIDSTAKQLSKIGGGVAINLSKLRARGEAIKGIKGVAKGVLPVAKALEGGFSYADQLGQRPGA 247 Staphylococcus
WP_002969365 199 LVSCFLLRVEDNMESIGRSINSALQLSKRGGGVALCLTNLREAGAPIKQIENQSSGIIPVMKLLEDSFSYANQLGARQGA 278 Brucella

1PEM_A       255 GAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFRLAKENAQMALFSPYDIQRRYGKPFGDIAISERYDEL 334 Salmonella ente...
WP_011075917 262 GAVYLNAHHPDILSFLDTKRENADEKIRIKTLSLGVVIPDITFELAKRNDDMYLFSPYDVERIYGKPFADISVTELYNEM 341 Corynebacterium...
WP_011579166 242 GAVYLHAHHPDILRFLDTKRENADEKIRIKTLSLGVVIPDITFHLAKENAQMALFSPYDVERVYGKPFADVAISERYDEL 321 Escherichia coli
WP_000523249 249 GVVYLNVFHPDIIAFLSTKKENADEKVRVKTLSLGVVVPDKFYELARKNEEMYLFSPYSVEKEYGVPFNYIDITEKYDEL 328 Streptococcus
WP_003245700 247 GAAYLNIFHRDINDFLDTKKISADEDVRVKTLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKF 326 Bacillus subtilis
WP_001829582 248 GAVYLNIFHYDVEEFLDTKKVNADEDLRLSTISTGLIVPSKFFDLAKEGKDFYMFAPHTVKQEYGVTLDDIDLEKYYDDM 327 Staphylococcus
WP_002969365 279 GAVYLHAHHPDIMRFLDTKRENADEKIRIKTLSLGVVIPDITFELARNNEDMYLFSPYDVQRVYGVPLTEISVTEKYREM 358 Brucella

1PEM_A       335 IADPHVRKTYINARDFFQTLAEIQFESGYPYIMFEDTVNRANP--IAGRINMSNLCSEILQVNSASRYDDNLDYTHIGHD 412 Salmonella ente...
WP_011075917 342 VDDDRIRKTKINARQFFQTLAEIQFESGYPYIMFEDTVNEANP--IEGRVTHSNLCSEILQVSTPSTYHEDLSYDEVGED 419 Corynebacterium...
WP_011579166 322 VADERIRKKYLNARDFFQRLAEIQFESGYPYIMYEDTVNRANP--IAGRINMSNLCSEILQVNSASEYDENLDYARTGHD 399 Escherichia coli
WP_000523249 329 VANPNIRKTKIKARDLETEISKLQQESGYPYVVNIDTANRANP--VDGKIIMSNLCSEILQVQEPSLINDAQEFLQMGTD 406 Streptococcus
WP_003245700 327 VDNPRVKKEKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHAnnHISKVKFSNLCSEVLQASQVSSYTDYDEEDEIGLD 406 Bacillus subtilis
WP_001829582 328 VANPNIDKKKKDAREMLNMIAQTQLQSGYPYLMFKDNANKVHAnsNIGQIKMSNLCTEIFQLQETSVINDYGIEDEIKRD 407 Staphylococcus
WP_002969365 359 VNDAQIAKKKINAREFFQVLAEIQFESGYPYIMFEDTVNRANP--IDGRITMSNLCSEILQVSEASLFHEDLSYEYLGKD 436 Brucella

1PEM_A       413 ISCNLGSLNIAHVMDSPDIGRTVETAIRGLTAVSDMSHIRSVPSIAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALD 492 Salmonella ente...
WP_011075917 420 ISCNLGSLNIAMAMDSPDFSRTIETAIRGLTAVSEQTSIDSVPSIRKGNEAAHAIGLGQMNLHGYLGREHIFYGSEEGLD 499 Corynebacterium...
WP_011579166 400 ISCNLGSLNIAHTMDSPDFARTVETAVRGLTAVSDMSHIHSVPSIEAGNAASHAIGLGQMNLHGYLAREGIAYGSPEALD 479 Escherichia coli
WP_000523249 407 VSCNLGSTNVVNMMTSPDFGRSIRAMVRALTFVTDSSHIVAVPTIDHGNSQAHTFGLGAMGLHSYLAQQLIEYGSPESVE 486 Streptococcus
WP_003245700 407 ISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPAVRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARD 486 Bacillus subtilis
WP_001829582 408 ISCNLGSLNIVNVMESGKFRDSVFTGMDALTVVSDEANIQNAPGVKKANSELHSVGLGVMNLHGYLAKNKIGYESEEAKD 487 Staphylococcus
WP_002969365 437 ISCNLGSLNIAAAMDAPDFGKTIETSIRALTAVSDMSHIGCVPSVARGNAESHAIGLGQMNLHGYLARERIFYGSEEGVD 516 Brucella

1PEM_A       493 FTNLYFYTITWHAVHTSMRLARERGKTFAGFAQSRYASGDYFTQYLQDDWQPKTAKVRALFarS--G--ITLPTREMWLK 568 Salmonella ente...
WP_011075917 500 FTNAYFAAVLYECLRASNKIARERGQRFANFENSDYASGVYFDRFDPAEFAPKTDKVKELF--A--NstIHTPTAEEWAQ 575 Corynebacterium...
WP_011579166 480 FTNLYFYTITWHALRTSMLLARERGETFAGFKQSRYASGEYFSQYLQSNWQPKTAKVGELFarS--G--ITLPTREMWAQ 555 Escherichia coli
WP_000523249 487 FTSIYFMLMNYWTLVESNNIARERGITFHNFEKSDYANGSYFDKYVTGEFVPTSDRVKELF--K--N--VFIPGVADWAE 560 Streptococcus
WP_003245700 487 FANTFFMMVNFYSIQRSAEIAKEKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLF--E--G--MHIPTTEDWKK 560 Bacillus subtilis
WP_001829582 488 FANIFFMIMNYYSIERSMEIAKERGEKYQDFEQSDYANGKYFEFYTSQEFEPKFEKVRQLF--D--G--IDIPTSNDWKE 561 Staphylococcus
WP_002969365 517 FTNIYFYTVAYHAVRASNRIAVETGKSFKGFEKSKYASGEYFDKYTDQAWAPATEKVRRIF--EdaG--IAIPTQDDWCA 592 Brucella

1PEM_A       569 LRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKIEIRKEGKTGRVYYPAPFMTNENLDMYQDAYDIGPEKIID 648 Salmonella ente...
WP_011075917 576 LKADVMEHGLFNRYLQAVPPTGSISYINNSTSSIHPIASKIEIRKEGKIGRVYYPAPHMDNDNLEYFQDAYEIGYEKIID 655 Corynebacterium...
WP_011579166 556 LRDDVMRYGIYNQNLQAVPPTGSISYINHATSSIHPIVAKVEIRKEGKTGRVYYPAPFMTNENLALYQDAYEIGAEKIID 635 Escherichia coli
WP_000523249 561 LRDKVQEDGLYHQNRLAVAPNGSISYINDVSASIHPITQRIEERQEKKIGKIYYPAAGLSTETIPYYTSAYDMDMRKVID 640 Streptococcus
WP_003245700 561 LKAFVAEHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGN-SKTYYPMPGLASNNWFFYKEAYDMDMFKVVD 639 Bacillus subtilis
WP_001829582 562 LQNKVEQYGLYHAYRLAIAPTQSISYVQNATSSVMPIVDQIERRTYGN-AETFYPMPFLSPETMWYYKSAFNTDQMKLID 640 Staphylococcus
WP_002969365 593 LKKAVMEGGLYNQNLQAVPPTGSISYINHSTSSIHPIVSKIEIRKEGKIGRVYYPAAFMTNDNLEYYQDAYEIGPEKIID 672 Brucella

1PEM_A       649 TYAEATRHVDQGLSLTLFFP-------------DTATTRDINKAQIYAWRKGIKSLYYIRLRQLALEGTEIEGCVSCAL 714 Salmonella enter...
WP_011075917 656 TYAVATKYVDQGLSLTLFFK-------------DTATTRDINRAQIYAWRKGIKTLYYIRLRQVALEGTEIDGCVSCML 721 Corynebacterium ...
WP_011579166 636 TYAETTRHVDQGLSLTLLFL-------------DTATTRDIDKAQIYAWRKGIKTLYYIRLRQMALEGTEIEGCVSCAL 701 Escherichia coli
WP_000523249 641 VYAAATEHVDQGLSLTLFMRsdipkglyewkreNKQTTRDLSILRNYAFNKGIKSIYYVRTFTDDGGEVGANQCESCVI 719 Streptococcus
WP_003245700 640 MIATIQQHIDQGISFTLFLK-------------DTMTTRDLNRIDLYAHHRGIKTIYYARTKDTGQD-----SCLSCVV 700 Bacillus subtilis
WP_001829582 641 LVATIQTHVDQGISTILYVN-------------SEISTRELSRLYVYAHHKGLKSLYYTRNKLLSVE-----ECTSCAI 701 Staphylococcus
WP_002969365 673 TYAAATQHVDQGLSLTLFFR-------------DTATTRDINRAQIYAWKKGIKTIYYIRLRQMALEGTQVQGCVSCAL 738 Brucella
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