1FM0,1NVJ,1NVJ,1NVJ


Conserved Protein Domain Family
MoaE
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cd00756: MoaE 
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MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.
Links
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Statistics
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PSSM-Id: 238385
Aligned: 144 rows
Threshold Bit Score: 97.973
Created: 4-Feb-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:active site residues [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
1FM0_E       13 FSVGEEYPWLAerd---edGAVVTFTGKVRNhnl-gdSVNALTLEHYPgMTEKALAEIVDEARnrw-plGRVTVIHRIGE 87  Escherichia coli
ZP_01061658  14 FIGGSIAKHQSkt----siGAHNIFLGQVRAddvdgkKVAAIEYTCYEeLANTKLHEIREAAFekf-dlICMHIYHSLGT 88  Flavobacterium s...
AAY80314     92 FNLLEEIRKFRaeat-eevGSMVIYLGIVKGaie-ehKVYELRYEAYKeYTEKRLKEIIENLRtkykdlVKMKILHVVDD 169 Sulfolobus acido...
ZP_01119756  27 FIAQSIAKHQSkt----giGAHDIFLGQVRAdeidgkTVTGIAYTAYEeMAHEKMHEIREDLFgky-dlSCMHIYHSLGE 101 Robiginitalea bi...
AAL62982     96 EDIIKNTAHLGg-------GGVVIFVGYVKGkvd-kaAVNVLEYEAYEpYASSKIKEIEAWARdqa-gvLDARIYHVVGA 166 Pyrobaculum aero...
AAM05381    146 YTLEALIKKARknpviqkaGAIGTFTGIVRElag-eeKTARLEFEKYEpEASKVLDKIGEEIKqke-giLEVLLHHKTGV 223 Methanosarcina a...
2648344     104 ESLKSIVLKTKcvegvekcGAIGIFIGFVRKesd-gkTVSRLEYEAYDeMLNEKAREIEERVKqmp-giVNARVYHKRGI 181 Archaeoglobus fu...
CAJ37496    138 VTLPELIARVHrnpeikkaGAIGTFTGIVREiak-neITKALEFESYDvVAKERIAKIEADLKqap-giVDVIIHHKTGR 215 uncultured metha...
AAK42541     94 FDLLEEIRKFRekap-peaGSLVVYVGFVKGivd-nhRVFELKYEAYEeYTRKRFLEIKDEIKkkyndlIEIEIIHVIDS 171 Sulfolobus solfa...
YP_392770     9 LDVPRILKEWYeqeassnyGAYIPFVGTVRSe----dGIDGLSFDIYEpILNSWFDAWQKKAKer---gAIIKMAHSRGD 81  Thiomicrospira d...

Feature 1                                      #      #            
1FM0_E       88 LWPGDEIVFVGVTSAHRSSAFEAGQFIMDYLKTRAPFWKREATP-EGDRWV 137 Escherichia coli
ZP_01061658  89 IKTGEICFFVFVSATRRKEVYAATEWLVNQVKEHTPIYGKEIFEdETHQWK 139 Flavobacterium sp. MED217
AAY80314    170 LKPGDDVFLVMALGRGRGDTLKAVEEAVELVKHTTGIWKLEIRD-DGEYWV 219 Sulfolobus acidocaldarius DSM 639
ZP_01119756 102 VAVGEICLFVFVSSPHRKAVFEALHELVERIKKELPVFGKELFGdDSYAWK 152 Robiginitalea biformata HTCC2501
AAL62982    167 LKPGDHTLYVFVSAINRDIAFSVAREALERVKHEVPIFKLERRS-DGEFWV 216 Pyrobaculum aerophilum str. IM2
AAM05381    224 IEAGEDIVYIVIASAHRAELFPALSEAIERIKAEAPIWKKEFTE-KEEFWV 273 Methanosarcina acetivorans C2A
2648344     182 LLPGEDIVYITVMGEHRKDIWEPLKEAVELMKKELPIWKKEVYE-DGEVWV 231 Archaeoglobus fulgidus DSM 4304
CAJ37496    216 IEAGEDIVYIVVAAGHRQELFPILREAIERVKEEVPIWKKEMTV-SGEYWV 265 uncultured methanogenic archaeon RC-I
AAK42541    172 MKPGENVLLIMAIGKGRKDAIDAVKETLELVKHSTGIWKLEIRD-DGEYWV 221 Sulfolobus solfataricus P2
YP_392770    82 VMLHESSYIAAVFSPKRRVALEFIDEFVEDFKATAPIWKYDLKDaKRIYAL 132 Thiomicrospira denitrificans ATCC 33889

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