Conserved Protein Domain Family
LRRFIP

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pfam09738: LRRFIP 
LRRFIP family
LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin.
Statistics
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PSSM-Id: 462869
Aligned: 16 rows
Threshold Bit Score: 269.644
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009026647   44 S--------AVLAEARKLRLDEREKHKKEnedVDEDDDEESTENSKQsadntanienipaskvptTATTTTSTTSTTSQP 115 
XP_015838716   28 AearlwakrQARAEAREIRMRELERQQKE---QEENADRQFDMLAEP------------------MARTARTVTAGSRYL 86  
XP_002430218   31 AearltarrQARVEAREIRLRELERQQKE---QEENADRVYDMSHSGdntm-----------rpgRVSNAAMVSGKDRQN 96  
XP_011142076   29 AearlaarrQARAEAREIRMRELEKQQKE---AEENADRVYDMCTADvnrtm--------rvtpdPVRTSRLLTNSNNFQ 97  
XP_002058797   29 AearlaarrLARAEAREIRMRELERQQKE---LEQNADRAFDMQSTSgsviidt-----lsshptRHGY-SGLVNLVRAT 99  
XP_002075408   70 AearlaarrQARAEAREIRMRELERQQKE---QEQNADRVFDMQNTSgvggdt------isthpaRLVYGGGLLNVTRAT 140 
XP_001966666   27 AearlaarrQARAEAREIRMRELERQQKE---QELNADRVFDLQNISggnivid----thsnnspRLIY-GGLLNATRTS 98  
XP_002044202   30 AearlaarrQARAEAREIRMRELERQQKE---QEITADRVFDMQNSTavgset------lsahpvRIAY-GGLLNVTRAS 99  
XP_005167696   31 AearlaakrAARAEAREIRMKELERQQKE---VSDDEERMSVGSRSNvraddrlerdylekgssrASTISGTTLTSLGGT 107 
3_pfamImport    1 AearlaakrAARAEAREIRMKELERQQKE---LSDDDERMSVGSRGSvrg------------sraASALTAATLTSVGGT 65  
XP_009026647  116 I-------TRMHSTtDSrpvLEHSS-SRQQDTTGSADLMEKYKKVLLSNAQLDNEKRALKYEVDLLKDRMCDVEESNLET 187 
XP_015838716   87 S-------SRRSSE-DS---LEDGG-SLRDLRNELKEYEEKFRKAMIANAQLDNDKTSLTYQLELLKDRLEELEEEHSQL 154 
XP_002430218   97 SfinnyygSRRSSD-DS---NEDGSyCLRDVKHELKEVDEKFRKAMIANAQLDNEKSELVYQVELLKDKLEELEESHIQL 172 
XP_011142076   98 S-------SRRSSE-DS---LEDAG-LSRDIRLELKEFEEKFRKAMIANAQLDNEKSSYAYQVDLLKDKLEELEETTAQL 165 
XP_002058797  100 T-------SRRSSE-DS---LEDEGrSFRDIKHELKEVEERFRKAMITNAQLDNDRSSQTYEVKLLKDKSETMEESFAQL 168 
XP_002075408  141 A-------SRRSSE-DS---LEDESrSLRDMKHELKDVEERFRKAMITNAQLDNDRASQTYEVKLLKDRSETMQESLAQL 209 
XP_001966666   99 A-------SRRSSE-DS---LEEDGrSFRDFKNELKDVEERFRKAMITNAQLENDRASQVFEVKLLKDKCEIIQESYVQL 167 
XP_002044202  100 A-------SRRSSE-DS---VEEEGrSFRDFKHELKDVEERFRKAMITNAQLDNDRASQAYEVKLLKDKCEIMEESYAQL 168 
XP_005167696  108 S-------SRRGSG-DTsisADTEA-SIREIKDSLLEVEEKYRKAMVSNAQLDNEKTNMMYEVDTLRDSLMELEEMLFET 178 
3_pfamImport   66 S-------SRRGSG-ETaiaIDAET-SIREIKDALGEVEEKYRKAMVSNAQLDNEKNNLMYQVDTLKDSLMELEELLSES 136 
XP_009026647  188 KRSLRISNKEKDALLDQLRALESKCQKLTVDLIQRDHLIKTSGLALVTTDNTYTApe---dsEYTSGSNMSSAILTAEHL 264 
XP_015838716  155 KREHREKCRDFDQLKRLCAKLKDDLAVTRAELEERDQLISEKGLVIVGEDSINEEeqrngdvSLSSIGTPKKALVSVENA 234 
XP_002430218  173 QKENRDKCREHEQLKRVALKLKDDLVSYKSQLEERDRLIANYGLMIVGGEDEEGP--------------SERALVTVETA 238 
XP_011142076  166 RRELREKNRDVEQLKRVSQRLKEDLDFCRAQLYDRDELIKENGLVIVEYVSDDDYe-----nTENGPCQPRRVLVSTEAA 240 
XP_002058797  169 QREFKNKLRDCNTLKRNLERTTLELSLVQGQLCERDALIEEHGLIIVSIENSDGS-------------DAKRALVSVENA 235 
XP_002075408  210 QREYKEKMREYNALKRNLDRTTLELQLVQGQLNERDSLIAEQGLVIVAIENSDGS-------------DAKRALVSVDNA 276 
XP_001966666  168 QREFKEKLRDCNLIKRNLDRTTLELNLVQGQLNERDHLISEHGLIIVAIENSDGS-------------DAKRALVSVENA 234 
XP_002044202  169 QREFKEKMRDCNALKRNLDRANLELKLVQGQLNERDSLIAEQGLLIVAVENADGS-------------DAKRALVSVENA 235 
XP_005167696  179 RRELEEKIKDLEREKHAHSILQFQFSELKETLKQSEELLSKHGIVLGPDLVTNGEt-----gDEVGNADPNSQTASAEIR 253 
3_pfamImport  137 RRGYEDKVKEYEREKHSHTVLQFQFTEMKETLKQSEELLNKHGIVLGPDLNINGEl-----gEAEVVETPGADHVTQPAA 211 
XP_009026647  265 EILADY---TGSLGDRLKKLFDERNEILEEKEKISKELSELKSNSSNLLQQQQTSSFSTIASPvfdgIVFD---DAHK-- 336 
XP_015838716  235 QLLQSAg--EGSLDVRLAKLMKEKGELQDQISHLKLELEEERSKRKKSSAGGTLNGPSSDPDL----DEIDiqrEASK-- 306 
XP_002430218  239 DLLQKVg--EGSLDVRLKKIVEERNELFDEVRHLKLELEEEKSKRRIDGKSGYSAANG------------LideETSK-- 302 
XP_011142076  241 ELLETAg--KGSLDVRLRKFASEKKELQDEIRHLRLELEETRSRVRSERSSGSVLGCLSDN--------DDiqrEANK-- 308 
XP_002058797  236 NILSTV---QGSLDVRLKKFAEENQRLLNEIQKLHEQLGAFKSEGRVGRGSSLCGSLRYDDD-------YEvqrESNK-- 303 
XP_002075408  277 NVLASV---QGSLDVRLKKFSEDKQLLLAEVQKLNEQLEEYKSDGKIGHGSSSYGTFGYDDD-------YEaqrEANK-- 344 
XP_001966666  235 NVLASV---QGSLDDRLKKFSDEKQKLLSEVHLLHKQLDEHKS-GVMVRSSFTHGA---EED-------YEtqrESNK-- 298 
XP_002044202  236 KVLASV---QGSLDVRLKKFSDEKQRLLAEVQKLHEQLDEYKSDGISGRRSLSQGSFGDEND-------YEaqrETNK-- 303 
XP_005167696  254 Eg-------SSVLGIHQLKHKD------QEQKYLDDEVQGNQQSSNALFSSTNPPLEANDNGVlgdsVVPGvgqHENRte 320 
3_pfamImport  212 DAQGAPtegNSMLEIRLRKLVDEREKMIEQVKKLKSQLDLKTQ-RNGTDSSVSPDGEILENGNd--pNLIElqrDSSR-- 286 
XP_009026647  337 -----------NFTEIKLKLKKAEQEITT 354 
XP_015838716  307 -----------QLGDYKFRAQKAEQDVAT 324 
XP_002430218  303 -----------IMSDYRFKLQKAEQDVST 320 
XP_011142076  309 -----------LLADYKFKLQKAEQDMST 326 
XP_002058797  304 -----------IISDYKYKLQKAEQEIAS 321 
XP_002075408  345 -----------IISDYKYKLQKAEQEIAS 362 
XP_001966666  299 -----------IIADYKYKLHKAEQEIAN 316 
XP_002044202  304 -----------IISDHKYKLQKAEQEIAN 321 
XP_005167696  321 eplssvgdeevTATAPKEEVKSEEHELKd 349 
3_pfamImport  287 -----------QISDFKFKLVKTEQEVTA 304 
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