1OJX


Conserved Protein Domain Family
DhnA
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cd00958: DhnA 
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Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs)
Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs) found in bacteria and archaea. Catalysis of the enzymes proceeds via a Schiff-base mechanism like other class I aldolases, although this subfamily is clearly divergent based on sequence similarity to other class I and class II (metal dependent) aldolase subfamilies.
Links
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Statistics
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PSSM-Id: 188645
Aligned: 35 rows
Threshold Bit Score: 208.987
Created: 11-Apr-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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putative activecatalytic
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
1OJX_A       18 SIILAYDHGIehgp---adfmDNPDSADPEYILRLARdaGFDGVVFQRGIAEKYYDG---SVPLILKLNgkttlyn---g 88  Thermoproteus tenax
P71295       68 LSILPVDQGVehsag--asfaANPLYFDPKNIVELAIeaGCNCVASTYGVLASVSRRyahRIPFLVKLNhnetlsyp--n 143 Escherichia coli O6
Q9Z8Q7       68 LSILPVDQGIehsag--asfaINPIYFDPENIVKLAIesGCSAVASTYGTLSLLSRKyahKIPFMLKLNhnellsyp--t 143 Chlamydophila pn...
NP_487775    74 LSILPVDQGIehsag--asfaPNPIYFDPENIIRLAIagGCNAVATTLGVLGSVSRKyahKIPFIAKLNhnelltfp--n 149 Nostoc sp. PCC 7120
NP_711713    69 TSILPVDQGIehsag--asfaKNPAYFDPENIVKLAIegGCNAVASTLGVLGLVSRKyahKIPFIVKINhnellsyp--n 144 Leptospira inter...
NP_810572    68 VSILPVDQDIehtag--asfaPNPIYFDPENIVKLAIegGCNAVASTFGILGSVARKyahKIPFVVKLNhnelltyp--n 143 Bacteroides thet...
NP_866279    85 VSILPVDQGIehsag--asfaPNLDYFDPENIVKLAIegGCNAVASTFGVLGAVSRKyahRIPFLVKINhnellsyp--n 160 Pirellula sp. 1
NP_969166    38 LVILPVDQGFehgpa--rsfaKNPDGYDPAYHVELAIesGCSAYAAPLGAIEAIARDyagEIPLILKINnsdslyan--k 113 Bdellovibrio bac...
NP_987413    38 LMLFAGDQKIehlnndfygenISKDDADPEHLFKIAKnsKIGGFAVQFGLLSRYGQNy-kDINYIVKLNsktnlvdvdqk 116 Methanococcus ma...
ZP_00295512  37 LMLFAGDQKVehlnddfygegVPEDDGDPEHLFRIASqsKIGVFATQLGLISRYGMDy-rDVPYLVKVNsktnlvgtaqs 115 Methanosarcina b...

Feature 1                                                                                       
1OJX_A       89 epvsvaNCSVEEAVSL------GASAVGYTIYPGSgf--ewKMFEELARIKRDAvkfdLPLVVWSYPRGGkvvn-----e 155 Thermoproteus tenax
P71295      144 tydqtlYASVEQAFNM------GAVAVGATIYFGSee--srRQIEEISAAFERAhelgMVTVLWAYLRNSafkkdgvdyh 215 Escherichia coli O6
Q9Z8Q7      144 kyhqifFTQVEAAYSM------GAVAVGATVYFGSet--snEEIVAVSNAFAKArslgLATVLWCYLRNPafvangvdyh 215 Chlamydophila pn...
NP_487775   150 qfdqvlFADVEQAWNL------GAVAVGATIYFGSeq--stRQIQEISRAFKRAhelgMVTILWCYLRNNafkqdk-dyh 220 Nostoc sp. PCC 7120
NP_711713   145 kfdqilFANVEQAFDM------GAVAVGATIYFGSee--ssRQIQEISDAFHRAhelgLVTILWAYLRNDsfkpdkidyh 216 Leptospira inter...
NP_810572   144 tydqvlFGTVKEAWNM------GAVAVGATIYFGSeq--srRQLVEIAEAFEYAhelgMATILWCYLRNSdfkkgaidyh 215 Bacteroides thet...
NP_866279   161 tydqvmFGQVDRAHDM------GATAVGATIYFGSpe--srRQIVEVAESFERAhelgLATVLWCYLRNPafktdq-dyh 231 Pirellula sp. 1
NP_969166   114 apisamTSYIDDALRL------GCVGIGFTIYPGSae--rkNQYEEIAQAARAAkeagLAVIIWSYPRGEqlske---ge 182 Bdellovibrio bac...
NP_987413   117 dplsraLLDINDILEFkknsgvNIVGVGYTIYLGSey--esEMLSEASKIIYEAhkggLVVILWIYPRGKavqn-----e 189 Methanococcus ma...
ZP_00295512 116 dpfsnlWYDVDQVVEFke--nsGLKILGVGYTIYLgsefeaEMLVQAAQVIYDAhqhgMLSVLWIYPRGEavkd-----e 188 Methanosarcina b...

Feature 1                            #  #                                                       
1OJX_A      156 taPEIVAYAARIALELGADAMKIKYtg-----dPKTFSWAVKVAgk---------------------------------v 197 Thermoproteus tenax
P71295      216 vsADLTGQANHLAATIGADIVKQKMae-----nNGGYKAINYGYtddrvyskltsenpi------dlvryqlancymgra 284 Escherichia coli O6
Q9Z8Q7      216 taADLTGQADHLGATLGADIVKQKLpt-----cQGGFKAINFGKtdervyselssnhpi------dlcryqvlnsycgkv 284 Chlamydophila pn...
NP_487775   221 laADLTGQANHLGVTIEADIIKQKLpe-----nNNGYGAVAKATgqsygkthekvytdlttdhpidltryqvlncycgra 295 Nostoc sp. PCC 7120
NP_711713   217 laTDLTGQANHLGATIQADIVKQKLpe----vfAGGFKDLKFGKkddrmy------------------------tqltad 268 Leptospira inter...
NP_810572   216 aaADLTGQADRLGVTIKADIVKQKLpt-----nNGGFKAIGFGKtdermyteltsehpi------dlcryqvangymgrv 284 Bacteroides thet...
NP_866279   232 tsADLTGQANHLGVTIQADIIKQKLpt-----nNGGYNAIAFGKtsplvy------------------------qklttd 282 Pirellula sp. 1
NP_969166   183 tgIDVIAYAAHIAAQLGAHIIKVKPssa--hleQAAAKKVYEEQgikvss------------------------qvdrtr 236 Bdellovibrio bac...
NP_987413   190 kdPKLIAGATGVASCLGADFVKVNYpks--enpAESFKEAVMAAgr---------------------------------t 234 Methanococcus ma...
ZP_00295512 189 kdPHLIAGATGIGACLGTDFVKVNYpkkegaksAESFKEAIKAAgr---------------------------------t 235 Methanosarcina b...

Feature 1           ###                                          ###                            
1OJX_A      198 PVLMSGGp----------KTKTee----------dFLKQVEGV---LEAGALGIAVGRNVWQrr--dALKFARALAELVY 252 Thermoproteus tenax
P71295      285 GLINSGGaa--------gGETDls----------dAVRTAVIN---KRAGGMGLILGRKAFKksmadGVKLINAVQDVYL 343 Escherichia coli O6
Q9Z8Q7      285 GLINSGGp---------sGKNDft----------eAARTAVIN---KRAGGMGLILGRKAFQrplseGIQLLNLVQDIYL 342 Chlamydophila pn...
NP_487775   296 GLINSGGa---------sGKNDfa----------eAVRTAVIN---KRAGGTGLISGRKAFQrpfeeGVKLFHAIQDVYL 353 Nostoc sp. PCC 7120
NP_711713   269 NPIDMARyqva---ncymGKIGlinsgg-asgendLSDAVKAAvvnKRAGGMGLISGRKAFQksmkdGVALLNAIQDVYL 344 Leptospira inter...
NP_810572   285 GLINSGGes--------hGASDlr----------dAVITAVVN---KRAGGMGLISGRKAFQkpmnkGVELLNAIQDVYL 343 Bacteroides thet...
NP_866279   283 HPIDLCRyqvancfmgraGLINsggassgasdlaeAVKTAVIN---KRAGGTGLISGRKAFQrpmpeGVELLHKIQDVYL 359 Pirellula sp. 1
NP_969166   237 HIVQSCFngkrivifsggEAKStd----------dLLKEVGEL---AQGGAFGSIMGRNAFQrpkkeALELLHKVMEAFA 303 Bdellovibrio bac...
NP_987413   235 KVVCAGG-----------SSTDie----------sFLKQLYEQi--HISGASGNATGRNIHQkslsdAVAMCNAIYAVTI 291 Methanococcus ma...
ZP_00295512 236 KVVCAGG-----------SSDEag----------aFLKKLYDQi--HVSGAQGNATGRNIHQrpldeAVRMCNAVYAITV 292 Methanosarcina b...

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