2FMR,2QND


Conserved Protein Domain Family
KH_I_FMR1_rpt2
?
cd22509: KH_I_FMR1_rpt2 
second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins
FMR1, also called FMRP, or synaptic functional regulator FMR1, is a multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. It also plays a role in the alternative splicing of its own mRNA. FMR1 contains three K-homology (KH) RNA-binding domains. The model corresponds to the second one.
Links
?
Statistics
?
PSSM-Id: 411937
Aligned: 7 rows
Threshold Bit Score: 134.372
Created: 17-Aug-2020
Updated: 25-Oct-2021
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
putativeGXXG motif
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:putative nucleic acid binding site [nucleic acid binding site]
Evidence:
  • Comment:flanked by the GXXG motif and a variable ssRNA/DNA binding loop
  • Comment:Based on the structure evidence that other KH-I superfamily members bind RNA/ssDNA.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                  # ### #####  ##  ##     ####                         
2FMR_A         3 RFHEQFIVReDLMGLAIGTHGANIQQARKVpGVTAIDLDedtCTFHIYGEdqDAVKKARSFLE 65 
2QND_A         3 RFHEQFIVReDLXGLAIGTHGANIQQARKVpGVTAIDLDedtCTFHIYGEdqDAVKKARSFLE 65  human
P51113       218 RFHEQFIVReDLMGLAIGTHGANIQQARKVpGVTAIDLDedtCTFHIYGEdqEAVKKARTYLE 280 African clawed frog
XP_025005605 218 RFHEQFVVReDLMGLAIGTHGANIQQARKVpGVTAIDLDedtCTFHIYGEdqDAVKKARSYLE 280 chicken
XP_005991925 218 RFHEQFVVReDLMGLAIGTHGANIQQARKVpGVTAIDLDedtCTFHIYGEdhEAVKKARSYLE 280 coelacanth
XP_007891061 218 RFHEQFIVReDLMGLAIGTHGANIQQARKVsGVTAIELDeetCTFHIYGEdqEAVKQARNYLE 280 elephant shark
NP_694495    218 RFHEQFVERdDLMGLAIGTHGANIQQARKIsGVTTIDLDeetCTFHIYGEdqEAVRKARSYLE 280 zebrafish

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap