Conserved Protein Domain Family
PRK09426

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PRK09426: PRK09426 
methylmalonyl-CoA mutase; Reviewed
Links
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Statistics
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PSSM-Id: 236508
Aligned: 225 rows
Threshold Bit Score: 1076.04
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
111024184   7 KHAIGSFADVPLEdpqfpqpsaptpeqteeliaAAAAANHYSPEQVVWSTPEGIDVKPVFTKADRDAAEAEGypvgSFPG 86 
171463631   6 NNSWPSFPDANLEawk---------------ksAQKSAPSGDVDSLGWKTPDGIHLKALYTSSDIEGLNYTD----TLPG 66 
94985421    9 VPDLAAWKALAQK-----------------------ELRGADPATLNHVTPEGLTLKPLYTRADLEGV-PAD----TLPG 60 
134291468   1 -------------------------mneaaimaPDTEVERVGPND---RRARTVPLRKLYTQRDLEAVAHLG----SMPG 48 
15806104    7 MTDLSAWKAVARK-----------------------DLKGAEPDTLNRETPEGLTLKPLYTRADTAGL-NTD----TLPG 58 
226355691   1 MTDLSAWKALAQK-----------------------DLKGGDPATLNRETPEGLTLKALYTRADLPEGGAAD----TLPG 53 
145589093  21 TNPWPSFPETNLDawn---------------ksAQKSAPNGDVDKLGWNTPDGIQLKALYTSADTQDLNYTN----TLPG 81 
117923703   5 KPTLADWQALATK-----------------------SLKGKPLESLHWHSAEGIEVKSLYTSADLTAHGWESd---TMPG 58 
186473385   1 -------MNMQRR-----------------------------------RGSHRVRLKRVYTRADVDGIAHID----SMPG 34 
295680491   1 -------MNANRT-----------------------------------TRSRPVSLKPVYTRADLEGLAHLD----SMPG 34 
111024184  87 AAPFVRGPYPTMYVNQPWTIRQYAGFSTAAESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSI 166
171463631  67 FEPFVRGPQATMYSVRPWSIRQYAGFSTAEESNAFYRKALDAGGQGVSVAFDLATHRGYDSDHPRVTGDVGKAGVAIDSV 146
94985421   61 LPPFLRGPRATMYAARPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSV 140
134291468  49 AWPYVRGPYASMYTDRPWTIRQYTGHADAADSNLAFRTALEQGAQGLSVAFDLATQRGYDSDCVEAWADVGVAGVAIDTA 128
15806104   59 LPPYTRGPRATMYAARPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSV 138
226355691  54 LPPFTRGPRATMYAARPWTIRQYAGFSTAEESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSV 133
145589093  82 FEPFVRGPQATMYSVRPWTIRQYAGFSTAEASNAFYREALAAGGQGVSVAFDLATHRGYDSDHPRVAGDVGKAGVAIDSV 161
117923703  59 MAPYTRGPYPTMYASRPWTIRQYAGFSTAEASNAFYKRALAGGGQGISVAFDLATHRGYDSDHPRVVGDVGKAGVAIDSV 138
186473385  35 EAPFVRGPFATMYTQKPWTIRQYAGYAQASDTNLAFRTALAEGAQGLSVAFDLPTQRGYDSDDPAVSADVGMTGVAIDTV 114
295680491  35 EAPFVRGPFASMYTERPWTIRQYGGYAQAADSNRAFRTALTEGAQGLSVAFDLPTQRGYDSDDPRVSADVGMTGVAIDTV 114
111024184 167 LDMRQLFDHIPLDRVSVSMTMNGAVLPILALYVVAAEEQGVAPEQLAGTIQNDILKEFMVRNTYIYPPKPSMRIISDIFA 246
171463631 147 EDMKILFDGISLDKVSVSMTMNGAVLPVLAGYIVAGEEQGVKQEQLSGTIQNDILKEFMVRNTYIYPPEPSMRIIGDIIE 226
94985421  141 EDMKILFEGIPLGEMSVSMTMNGAVLPVLAAFIVAGEEQGVPRAQLSGTIQNDILKEFMVRNTYIYPPEPSMRIVADIIA 220
134291468 129 DDMVRLFDGIALDATTVSMTMNGAVLPIMAAFVVVAEEQGVPPERIGGTIQNDILKEYMVRNTWIFGPAPSMRIVADVAL 208
15806104  139 EDMKILFDGIPLNEMSVSMTMNGAVLPILAGYIVVGLEQGAKLEELSGTIQNDILKEFMVRNTYIYPPEPSMRIIADIIE 218
226355691 134 EDMKLLFADIPLSEMSVSMTMNGAVLPILAGYIVAAQEQGAALDQLSGTIQNDILKEFMVRNTYIYPPEPSMRIIADIIS 213
145589093 162 EDMKILFNGIPLDKVSVSMTMNGAVLPVLAGYIVAGEEQGVKQEALSGTIQNDILKEFMVRNTYIYPPEPSMRIIGDIIE 241
117923703 139 EDMKILFDGIPLDKVSVSMTMNGAVLPILAGYVVAAREQGVTEDQLSGTIQNDILKEFMVRNTYIYPPEPSMRIIGDIIV 218
186473385 115 EDMTRLFEDIALDRVSVSMTINGAVLPVLAAFIVAAEESGVSASQLRGTIQNDILKEFMVRNTSIFAPEPSLRIAADVVE 194
295680491 115 EDMARLFEGIALDRISVSMTMNGAVLPVLAAFIVVAEESGVRPSQLTGTIQNDILKEFIVRNTCIFAPEPSLRIVTDVVA 194
111024184 247 YTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVEYIRAGLDAGMEIDKFAPRLSFFWAIGMNFFMEVAKLRAGRL 326
171463631 227 YTAKHMPKFNSISISGYHMQEAGANQVLELAFTLADGKEYVKTALAKGLDVDGFAGRLSFFFAIGMNFYLEVAKLRAARL 306
94985421  221 FTAREMPKFNSISISGYHLQEAGANAALELAYTLADGLEYVRAALAKGLSVDEFAPRLSFFFAIGMNFYTEVAKLRAARL 300
134291468 209 WLAEHAPRFNALSVSGYHFQEAGADAVLELALTLSNARAYVDTLAARGMPADEACSRLSFFFGVGSDFYTEIAKLRAARL 288
15806104  219 YTAQNMPRFNSISISGYHLQEAGANAALELAYTLSDGLEYVRAALGKGLDVDAFAPRLSFFFAIGMNFYTEVAKLRAARL 298
226355691 214 YTARNMPRFNSISISGYHLQEAGANAALELAYTLADGLEYVRAALKAGLNIDEFAGRLSFFFGIGMNFYTEVAKLRAARL 293
145589093 242 YTAKNMPKFNSISISGYHMQEAGANQVLELAFTLADGREYVKTALAKGMDVDGFAGRLSFFFAIGMNFYLEVAKLRAARL 321
117923703 219 YASEHMPKFNTISISGYHIQEAGADAALELAYTLADGKAYVETAISRGLTVDAFAPRLSFFFGIGMNFFMEVAKLRAARL 298
186473385 195 YLSENVPRFNALSVSGYHFQEAGADPVLELALTMANARKYVTALVGRGMQADDVCQRMSFFFGVGMDFYAEIGKLRAARI 274
295680491 195 YLATAVPRFNALSVSGYHFQEAGADAVLELALTMANARAYVDALIRQGMEADHVCERMSFFFGVGTDFYVEIAKLRAARL 274
111024184 327 LWSELVAKFEPKSAKSLSLRTHSQTSGWSLTAQDVYNNVARTCVEAMAATQGHTQSLHTNALDEALALPTDFSARIARNT 406
171463631 307 LWWRIMKSFEPKNPKSLILRTHCQTSGWSLTEQDPYNNVVRTTVEAMAAVFGGTQSLHTNSLDEAIALPSEFSSRIARNT 386
94985421  301 LWDEIMAQFEPKNPMSRALRTHCQTSGWSLTEQDPYNNIIRTTIEAMAAVFGGTQSLHTNAFDEAIGLPTDFSARVARNT 380
134291468 289 LWAEIAHACGARSPRACALRMHCQTSGWSLTAQEAENNIVRVTAQAMAAAFGGTQSLHTNAYDEALALPSAAAARLARNT 368
15806104  299 LWDEIMAQFSPKNPMSRALRTHCQTSGWSLTEQDPYNNVVRTAVEAMAAVFGGTQSLHTNSFDEAIGLPTDFSARIARNT 378
226355691 294 LWSELIEQFGPQKPMSRALRTHCQTSGWSLTEQDAYNNIVRTTIEAMAAVFGGTQSLHTNAFDEAIGLPTDFSARIARNT 373
145589093 322 LWWRIMKSFEPKNPKSLMLRTHCQTSGWSLTEQDPYNNVVRTTVEAMAAVFGGTQSLHTNSLDEAIALPSEFSSRIARNT 401
117923703 299 LWTRIMEGFKPSDPRSSMLRTHCQTSGWSLTSQDPYNNVVRTTVEAMAAVFGGTQSLHTNALDEAMALPTDFSARIARNT 378
186473385 275 LWSDIASASGATSDRARALRMHCQTSGWSLTAQKPMNNVVRTTVEALAAVFGGTQSLHTNGYDEALSLPCAEASSLARDT 354
295680491 275 VWSTLARESGARSNRACALRMHCQTSGWSLTAHKPMNNVVRTAIEALAAVFGGTQSLHTNAFDEALALPGASSSRLARDT 354
111024184 407 QLLLQQESGTVRPIDPWGGSHYVEWLTHQLANRARAHIAEVEEAGGMAQAISEGIPKLRIEEAAARTQARIDSGRQPLVG 486
171463631 387 QLILQEETHIPSVIDPWAGSYMMENLTQEMADKAWEIIQEVEAMGGMTKAVESGWAKLKIEAAAAEKQAKIDSGSDVIVG 466
94985421  381 QLILQEETGIPQVVDPWGGSYLMERLTFELAEKARELMREVEELGGMAKAIEAGIPKLRIEESAARKQARIDRGEDVIVG 460
134291468 369 QLILQHETGLCDTVDPWAGSYMMESLTDDIATRVRAELAAIDAQGGVIAAIESGWVKRRLLHAAAKTQAQVDSGRRTVVG 448
15806104  379 QLIIQEETGIPQVVDPWGGSYLMERLTHDLAEKARELMREVESLGGMAKAIESGVPKLRIEESAARKQARIDRGEDVIVG 458
226355691 374 QLVLQEETGIPDVIDPWGGSYMMERLTADLADKARELMREVEELGGMAKAIESGVPKLRIEESAARKQARIDRGEDVIVG 453
145589093 402 QLILQEETHITSVIDPWAGSYMMESLTQEMADKAWEIIQEVDSMGGMIKAVESGWAKLKIEAAAAEKQAKIDSGSDVIVG 481
117923703 379 QLILQEECHITHVVDPWAGSYMMESLTRALAEKAWAIFEEVEAKGGMVKAIAAGLPSRRIEASAAERQARIDKGLDVIVG 458
186473385 355 QLVLQHETGLCDVVDPWAGSYMMENLTAEICREALTLMAEIERRGGVIDVVESGWVREQIHRSALNTQAEIETGKRTVVG 434
295680491 355 QLVLQHETGVCDVVDPWAGSYMMESLTADIANRVRLQLDEIEARGGVMEAIHSGWIRERIRHSALGVQAEIESRERAILG 434
111024184 487 VNKYVP-DEADEIEVLKVENSRVRKEQLEKLDRLRADRDSDAVEAALAELSRAAatteAGAseatghvsmENNLLALAID 565
171463631 467 VNKYKL-GKEDLVDVLMIDNDKVRESQVTRLKDIKAKRDSQKVQAALEALTKAA----EDN---------SGNLLELSVN 532
94985421  461 VNKYRT-TDETPVEVLDIDNVAVREAQIKRLNRVKAERDPQAVARALAALEKAA----RTG---------EGNLLALSVD 526
134291468 449 VNRFVAsDPTDEFTVREMDGRHVRAGQARRIAAVKAARDPARVEAALWRLANAA----RDG---------GGNLLALAID 515
15806104  459 VNKYRP-TAETPVDVLDIDNAAVRESQIARLNKLRGERDGEAVQAALSALTECA----KTG---------QGNLLALSVE 524
226355691 454 VNKYRP-TMETPIEVLDIDNAAVRDSQIARLQRIRAERDGNAVEQALHALEECA----RSG---------QGNLLALSVE 519
145589093 482 VNKYKL-AKEDLVDVLMIDNEMVREGQVARLKEIKAKRDTQKVEAALDALTKAA----EDH---------TGNLLELSVN 547
117923703 459 VNRYRP-PQEDPVDVLVVDNDAVRTSQVARLQWVKANRDNAQVAEILARMTAAA----ASG---------EGNLLALAIE 524
186473385 435 VNNFMTgCNEDLGEPQAVDGRRVRVLQTQRLAHIKARRDPTRVRDTLDALTRAA----QSR---------DGNLLELTVA 501
295680491 435 VNCFERdDDDAPIAISQVDVQQIRRHQARRVAEVKAARDSARVRAALGALERAA----RDG---------AGNLLELTIE 501
111024184 566 AARAKATVGEISEALEKVYGRHQAEIRTI-SGVYRDEAGK-VENISKATELVEKFAEEEGRRPRVLIAKMGQDGHDRGQK 643
171463631 533 AIRLRATVGEVSDALEKVYGRHRADTQKV-TGVYAVAYDS-AKGWAKLQTEIADFAKDFGRRPRVMIAKLGQDGHDRGAK 610
94985421  527 AMRARATVGEVSDALERVWGRHQAEVRTL-SGIYAQGYHG-DEDFAALQREIEAFAEAEGRRPRILVVKMGQDGHDRGAK 604
134291468 516 CMRARATVGECTRALESVWPRHTAAVEANgAGAYGDH-RRgDAAWRAAKGCVGRLAQRAGRRPRIVIAKLGQDGHDRGAA 594
15806104  525 AMKVRCTLGEVSDALEKVWGRHSAEVRTL-SGVYAAGYEG-DEDFSALQRDIDAFAEAEGRRPRILVVKMGQDGHDRGAK 602
226355691 520 AMRVRATVGEVSDALERVWGRHSAEIRTL-SGVYAAGYAG-DEGFAALQRDIEAFAEAEGRRPRILVVKMGQDGHDRGAK 597
145589093 548 AIRLRATVGEVSDALEKVYGRHRADTQKV-TGVYAAAYDS-AEGWAKLQTEIADFAKDFGRRPRVMIAKLGQDGHDRGAK 625
117923703 525 ATAARATGGEITSALEQVYGRFQDKAQAT-TGVYGKVWEE-DETWKALRRDIEAFAQEEGRRPRLLVVKMGQDGHDRGAK 602
186473385 502 CMRARATVGECTQALEAVWPRYRIGLPLS-RDRYGAKLAS-DEDWQNACRAVADATKSLGRAPRVLIAKLGQDGHDRGAR 579
295680491 502 CMRARATVGECTQALEAVWPRHPIQIQAA-AGQFGERLSA-DPGWSAALKTVKSAASQLGRAPRVLIAKLGQDGHDRGVS 579
111024184 644 VIATAFADIGFDVDVGPLFQTPEEVANQAADNDVHVVGVSSLAAGHLTLVPALREALAAVGRPDIMIVVGGVIPPGDFAE 723
171463631 611 VVATAYADLGFDVDIGPLFQTPEECARQAIENDVHALGVSTLAAGHKTLVPAIIAELKKQGSDDIIVFVGGVIPRQDYEF 690
94985421  605 VIATGFADLGFDVDVGPLFQTPEEAARQAIENDVHVIGVSSQAAGHKTLIPQLVEALRAEGADDILVVAGGVIPQQDYAA 684
134291468 595 VVAAALEDAGFDVLRLPLFQQPICVAAAVQAYGADIVGVSSLSGGHRELVEGLLDELASL-RAGIPVVLGGIFPAADARH 673
15806104  603 VIATGFADLGFDVDVGPLFQTPEEAARQAVENDVHVVGVSSQAAGHKTLVPQLIQALRAEGAGDILVVVGGVIPQQDYPA 682
226355691 598 VIATGFADLGFDVDVGPLFQTPEEAARQAVENDVHVVGVSSQAAGHRTLVPQLIQALRAQGAGDVLVVVGGVIPQQDYAA 677
145589093 626 VVATAYADLGFDVDIGPLFQTPEECARQAIENDVHALGVSTLAAGHKTLVPAIIAELKKQGSDDIIVFVGGVIPRQDYEF 705
117923703 603 VIASAFADLGFDVDLGPLFQTPEEAAQQAVENDVHVLGVSTLAGAHHTLIPALIRALCAEQAEDVLVVAGGVIPEQDYAF 682
186473385 580 IVAAALSDAGFAVSAGSMFASPSDTAVLAGGERVDVIGVSSLAGAQNDLIAALREQLTERGLR-IPIVVGGIIGQASQLV 658
295680491 580 VVAAALADAGFDVVTGQMFASAAETGIKALKHDVDVIGVSSLAGAHVELASLLIADLQARNA-TIPIVVGGNIDDSSQAV 658
111024184 724 LYEAGAAAIFPPGTVIADAASGLLEKLAAQLGHD 757
171463631 691 LYEAGVKGIYGPGTPIPVSAKDLLEQIRKSVKPA 724
94985421  685 LRAAGVAGIFGPGTPILHSAREVLRLLRARQLGA 718
134291468 674 LKAKGVAASFGPGTPLDAIVEALCACIERARCVH 707
15806104  683 LREAGAAGIFGPGTPIMSSARDVLDLLRK----- 711
226355691 678 LRDAGAAGIFGPGTPILHSAREVLELLRDRQPV- 710
145589093 706 LYEAGVKGIYGPGTPIPASAKDVLEQIRKSMKPV 739
117923703 683 LREAGVAEIFGPGTSVVDAAGRVLRAIRAKRG-- 714
186473385 659 LQRSGVAACFPAGTPIKNMVPLLAAIAVASAEKR 692
295680491 659 LKRLGVAECFPTGTSVAHIVAKLAGLSCRGLVER 692
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