Conserved Protein Domain Family
PRK06975

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PRK06975: PRK06975 
bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed
Statistics
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PSSM-Id: 235899
Aligned: 35 rows
Threshold Bit Score: 720.349
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
194290489   1 MPRPTVVVTRPAGQSRQLTEALQGAGLDVLSFPLLAIGPAADDAPLRAALARLDTFALVVFVSPNAIAFALDALAGVqgs 80 
17547075   19 PSAPVVIVTRPRAQAPMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYALVVFVSPNAVQQAFAAMPEGf-- 96 
300703402  25 ASAPVVVVTRPRAQAPMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYALVVFVSPNAVQQAFSAMPEGf-- 102
300690777  19 PSAPVVVVTRPRTQAPMLVAALERHGLRTLQFPLLDIAPTPNLDDLRAALADPSRYALVVFVSPNAVQQAFSAMPEGf-- 96 
187929643  24 ATPPVVVVTRPRAQAPMLVAALERHGLRTHQFPLLDIAPTPNLDDLRAALGDPSRYALVVFVSPNAVQQAFSAMPEGf-- 101
241663751   1 ----------------MLVAALERHGLRTHQFPLLDIAPTPNLDDLRAALGDPSRYALVVFVSPNAVQQAFAAMPEGf-- 62 
113868874   1 MPSPTVVVTRPAGQSRQLTEALQAAGLDVLSFPLLGIGPAVDDAPLRAALARLNTFALVVFVSPNAIAYALDALAGVqgv 80 
94311680    1 MPRPTVVVTRPAGQSRQLTEALQAAGLDVLSFPLLAIGPAADDVPLRAELGRIEDYALVVFVSPNAVSYGLDTLAQVqna 80 
186476929  25 GARLTVVLTRPAGQSEALARTLHDAGVATVEFPLIEIAATDDATPLRAALASLEKYALVVFVSPNAVDYAFANHDAI--- 101
73540407    1 MPRPTVVVTRPAGQSRQLTEALQAAGLDVLGFPLLSIGPAADDAPLRAALARLDQFALVIFVSPNAIQYAVDALAVVqgi 80 
194290489  81 a-varWPVPVAVAVVGPASVAALAERGIAAPAYRVIAPA--------GanangaghddtvpDAEALRFDSEALWAQLDPA 151
17547075   97 ----rWPQDVPAAVVGPASAQALAAHGVAAPTYRVIRPD--------S-------------HADDARQDSEALYARLDVA 151
300703402 103 ----rWPQDVPVAVVGPASAQALAAHGVEPPTHSVIRPD--------T-------------HADDARQDSEALYARLDPA 157
300690777  97 ----rWPQDVPVAVVGPASAQALAAHGVEPPTYRVIRPD--------S-------------HADEARQDSEALYARLDLA 151
187929643 102 ----rWPQEVPVAVVGPASAQALATHGVAPPAHRVIKPD--------T-------------HADDARQDSEALYARLDVP 156
241663751  63 ----rWPQEVPVAVVGPASAQALATHGVAPPAYRVIKPD--------T-------------HAGDARQDSEALYARLDVP 117
113868874  81 a-vaqWPAQVPVAVVGPASVAALAERGIAPPACRVIAPA--------GaaangqgpddaapEAEALRFDSEALWAQLDPA 151
94311680   81 pggarWPESVPVAVVGPSSVVALAERGITPPAYRVIAPA--------Gaqg-------ndtAGDAARFDSEALWSELDTS 145
186476929 102 -----WPHALPIGVVGPGSVAALAKHGVEAPAYQVISPG--------Aaa---------ddNGDGARFDSEALYSALEAS 159
73540407   81 a-aaqWPPGVPVAVVGPASVMALAERGIVAPDYRVIAPAgadgngtnGg-----------aNCEEARFDSEALWAQLEPA 148
194290489 152 A----LAGKPVLIIRGNGGRDWLGDRLREAGAQVEAVEAYQRTLPEPGAMQWQAVRDHLRPga-aPHAWLLTSSEAVRNL 226
17547075  152 T----LSGREVLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDTAAWAALREVLAG----RHAWTLTSSEAARNL 223
300703402 158 Q----LSGREVLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDAAAWAALREVLAG----RHAWTLTSSEAVRNL 229
300690777 152 P----LSGREMLIVRGNGGREWLADRLREAGVAVRTVEAYRRSVPVPDAATWAALREVLAG----RHAWTLTSSEAVRNL 223
187929643 157 S----LSGREVLIVRGNGGREWLADQLREAGASVRTAEAYRRSVPVPDAAAWLALRAVLSS----RHAWTLTSSEAVRNL 228
241663751 118 S----LSGREVLIVRGNGGREWLADQLREAGASVRTAEAYRRSVPVPDAAAWLALRAVLSS----RHAWTLTSSEAVRNL 189
113868874 152 A----LAGKPVLIIRGNGGRDWLGDRLREAGAQVEAVEAYQRTLPEPSAMQWQAVRDNLRPga-aPHAWLLTSSEAVRNL 226
94311680  146 Pg--aFAGRKVLIIRGSGGREWLADRLRDAGASVEAVEAYSRTLPEPSGMQWQAVRDSLKPda-pPYAWLLTSSEAVRNL 222
186476929 160 LgdnaFEGKRVLIVRGDGGREWLAERLREAGAEVETVAAYRRLVPEPSIGAWSRIHALLSDtstaRHAWLLTSSEGARNL 239
73540407  149 A----LQGRSVLIVRGNGGRDWLGDRLREAGADVTAVEAYQRTLPEPTAMQWQAVRDGLSPga-aPQAWLLTSSEAVRNL 223
194290489 227 DVLARQHLSPQEDAALRQVQCIAPHARIAEQALALGFAHIQRAAPGDAGLLAACLQWADAYAGPAPSSlpapsapaaakp 306
17547075  224 DSLARASLSAAEVEALYAAPCFAPHARIVEQAQSLGFRDVTLTGAGDDRLLAGVLAWAGPVALAAETTpspa-------- 295
300703402 230 DSLARASLTAAEVDTLHAAPCFAPHARIVEQAQSLGFRDVTLTGAGDDRLLAGLLAWVAPAAPVAPAAeavpsp------ 303
300690777 224 DSLARASLTAAEVDTLHAAPCFAPHARIVEQAQSLGFHDVTLTGAGDDRLLAGLLAWAGLVAPAAEAGpspa-------- 295
187929643 229 DELARANLSPADLDTLHGAPCFASHARIVEQAESLGFRDVTLTGAGDDRLLASVLAWAGPIWAPEHAPatvpdd------ 302
241663751 190 DELARANLSPADLDTLHGAPCFASHARIVEQAESLGFRDVTLTGAGDDRLLASVLAWAGPIWAPEHAPatvpdds----- 264
113868874 227 DALARQHLSPEEDAALRQVQCIAPHARIAEQALALGFPHILRAAPGDAGLLAACLQWADAHAGPAPASmasasieagpps 306
94311680  223 DGLARLHLSPQEHERLKQMQCIAPHARIAAQAQSLGFAHVLPAAPGDAGLLAACTQWGEAYAGPATPA------------ 290
186476929 240 AELAHDHLTNSEQTHLKRAMFVAPHPRIAETARALGFDSITVSGAGDERIARTLLSLATPPVVQAVQSn----------- 308
73540407  224 ETLARHNLSPQELATLKQVQCIAPHARIAEQAQALGFTRILRAAPGDAGLLAACKQWADAYAGPIAAStpvp-------- 295
194290489 307 aevaappaasapaavpamsTKVERVTQETTSSSATPPPG--AasvhTAQSAQAAPPQGAGHTGAAR-------------- 370
17547075  296 ---------------pvaaPAESNPSSPAPTVSQTPVPTsvPtpgpAAASPGLAPAPAAPTMTAGA-------------- 346
300703402 304 --------------apaaaPAEPKPSSPAPIVSQTSAPSsvPasgpAAASPGPAAAPAAPTTTVSA-------------- 355
300690777 296 ---------------paaaPAESKPSSPAPTVSQTSVPSsvPapgpAAASPGPAAAPAAPTMTVSA-------------- 346
187929643 303 --------------snpstSSSTVTQTPVPSSAPASTPA--PaavkPSPAPAAPPAAFAPTMTVNH-------------- 352
241663751 265 -------------npstssSTVTQTPVPSSAPAPASTPA--PaavkPSPAPAAPPAAFAPTMTVNH-------------- 315
113868874 307 ataeappapvpdaavpatsTKVERVTQETTSSSATPPPTaaSaasaQAASAPGPATPAAPSAASRR-------------- 372
94311680  291 -------------------PAPVSPAPAPVVVQPEPEPT--P----APMAPKEPTSTKVERVTTDTtspspnpggnpgss 345
186476929 309 -------------------PAQERMSDTNASTTPTPNPA-------PRPANTLPPNQPFTPYELQQ-------------- 348
73540407  296 ----------------avaPAPRPEPLPVPPPAMTNRVErvTqettSSSTTIPPGATASASPSASF-------------- 345
194290489 371 -------PAARRSAALWALVAVLVVATAggfwWLQQRVDHLTGELARRQQSNDALVQESRVLTRNAQDTVKELQAKVGAL 443
17547075  347 -------GPGRGGWLLWAALILALVVVA----GLQIRNERLAREVRQRAQQNETLAQEMRVLSRNNQDAFAQLQQKFGAL 415
300703402 356 -------RPGRGNWLLWAALTAVLVVVA----GLQVRNERLAREVRQRAQQNETLAQEMRVLSRNDQDAFAQLQQKFGAL 424
300690777 347 -------GPGRGNWLLWTALILVLVVVA----GLQVRNERLAREVRQRTQQNETLAQEMRVLSRADQDAFAQLQQKFGAL 415
187929643 353 -------APRRGGWLIWVALVAVVAAVA----ALQVRNERLAREIRQRAQTNEALAQEMRVLSRADQDSVSQLQQKFGAL 421
241663751 316 -------APRRGGWIIWVALVAVVAAVA----ALQVRNERLAREIRQRAQTNEALAQEMRVLSRADQDSVSQLQQKFGAL 384
113868874 373 ------------SAALWALVVVLVVATAggfwWLQQRVDHLTGELARRQQSNDALVQESRVLTRNAQDTVKELQAKVGAL 440
94311680  346 gmsgafvTPARRMNPWWLLVAVLVVAVAggfwWLQMRVEHLTQELARRQQSADTLVQETRVLSRDAQETVKALQGKVGAL 425
186476929 349 -------PNRKGNGLVWVVIALVLAAAVagglALNRRIIKLDQQLSHRQQANDAQMAELRVKTDQAVSTVRQADAQIAQL 421
73540407  346 -------AAPRRNAALWALVAVLVLATAggfwWLQQRVDHLTEELARRQQSNDALVQETRVLSRNAQDTVKELQAKVGAL 418
194290489 444 ENQVGETRDKQVALEQVYQDLMRNRDDWEIAEIQQLLTSAGQQLQLTGNVQVALAALQSADARLARADKPQYNLLRRAIA 523
17547075  416 DARTAETRDRQGALEQASQDLLRNRDDWQRAEIERSLEVASEQLQLTGNVSGALATLQTIDARLATVDKPQFRAMRRAVA 495
300703402 425 DARTAETRDRQGALEQASQDLLRNRDDWQRSEIERSLEVASEQLQLTGNVSSALVALQTIDARLASLDKPQFRAMRRAVA 504
300690777 416 DARTAETRERQGTLEQASQDLLRNRDDWQRAEIERSLEVASEQLQLTGNVSAALAALQTIDARLAALDKPQFRAMRRAVA 495
187929643 422 DARTAETRDRQAALEQANQDLLRNRDDWQRAEIQRSLEVTAEQLQLTGNVAGALAALQTIDARLATLDKPQFNAVRRAVS 501
241663751 385 DARTAETRDRQAALEQANQDLLRNRDDWQRAEIQRSLEVTAEQLQLTGNVAGALAALQTIDARLATLDKPQFNAVRRAVS 464
113868874 441 ENQVGETRDKQVALEQVYQDLMRNRDDWEIAEIQQLLTSAGQQLQLTGNVQVALAALQSADARLARADKPQYNLLRRAIA 520
94311680  426 DGQITETRDKQAALEQVYQDLMRNRDDWEIAEIQQLLTNAGQQLQLTGNVQVALAALQSADARLARSDKPQYNQLRRAIA 505
186476929 422 EGKLADAQNAQQALQQQYADLARNRDDWTMAEVGQMLSAASEQLQLTGNTQLALFALQSADTRLAASDGAQVLAVRKAIA 501
73540407  419 DGQVGETRDKQVALEQVYQDLMRNRDDWEIAEIQQLLTNAGQQLQLTGNVQVALAALQSADARLARTDKPQYNLLRRALA 498
194290489 524 RDVARMKAVPDTDLTGAAIKLDEAINQVDALPLLSSERMLERSEAda-------------rKGAAAGSGNGASSPAAASG 590
17547075  496 RDIAKLKAMPAVDLSGAAIRLDDAINGIDALPLVSSAAPLESGQAapasrgr--pakpgkgAAPASAFAASPAAESGWSA 573
300703402 505 RDIAKLKALPAIDLSGAAIRLDDAINGIDALPLVSAALPLEPQPAaqaphgr--pakpakaAAPASAPAAPVAAQSGWSA 582
300690777 496 RDIAKLKALPAIDLSGASIRLDDAINGIDALPLVSSASPLGSGQAaqasrghpakpgkavsAASASTPAASVATEAGWSA 575
187929643 502 RDMAKLKAMPSFDLAGAALRLDDAINAVDTLPLVSSAQPLEAEQAaqaphtva-kpsknakAHAASAPVASTPPNAGWSA 580
241663751 465 RDMAKLKAMPSFDLAGAALRLDDAINAVDTLPLVSSAQPLEAEQAaqaphtva-kpsknakAHAASAPVASTPPNAGWSA 543
113868874 521 RDVARMKAVPDTDLTGAAIKLDEAINQVDSLPLLSSERMLERSEAd---------------ARKGAAANGASAPAAAANG 585
94311680  506 RDIGRMKAVPDTDLTGAAIKLDEAINQIDSLPLLSGERMLDRTPGegnk---------papAAPKGASTPAAASATGGNM 576
186476929 502 QDIDRLKSAPSTDLTGLAIKLDNAIDQIDQLPLSGEAPIAHAT------------------PHASTPKDVDHVAAATGEP 563
73540407  499 RDIARMKAVPDTDLTGAAIKLDEAINQIDALPLLSSERMLERTEAedr-----------kdAGRGAAAKGTREASAPASG 567
194290489 591 NGPGWFTRFWDYLREELAQVIRIRKVDDAEALLLSGDQGWFLRENVKLRLLNARLALLSRNEPVFRNDLAAAQAMIGRYF 670
17547075  574 GVRAWWSRLWHDVRSELGQIVQVRRVDQTDALLLSSDQAWFLRENLKLWLMNARLALLSRNEAVFRADLGRADTLLARYF 653
300703402 583 GMRAWWGRLWHDVRHELGQIVQVRRVDQTEALLLSSDQAWFLRENLKLWLMNARLALLSRNDAVFRADLGRADALLARYF 662
300690777 576 GVRAWWSRLWHDVRSELGQIVQVRRVDQTEALLLSSDQAWFLRENLKLWLMNARLALLSRNEAVFRADLGRADTLLARYF 655
187929643 581 GVRAWWGRLWNDVRGELGQIVQVRRVDQTEALLLSSDQAWFLRENLKLRLMNARLALLSRNEAVFRADLGRADTLLARYF 660
241663751 544 GVRAWWGRLWNDVRGELGQIVQVRRVDQTEALLLSSDQAWFLRENLKLRLMNARLALLSRNEAVFRADLGRADTLLARYF 623
113868874 586 AGPGWFTRLWDYLREELAQVVRIRKVDDAEALLLSGDQGWFLRENVKLRLLNARLALLSRNEPVFRNDLAAAQAMISRYF 665
94311680  577 VSRLW-----TYVLDELGQVIRVRKVDDTNALLLSGDQGWFLRENIKLRLLNARLALLSRNEPVFRNDLAAAQGMIARYC 651
186476929 564 KWKVWWNQFVAGVGEQLTSLVQVRRIDHADAMLVAPDQGYFVRENLKLRLLSARLALLARNQTTLKSDLHAADSTIGRYF 643
73540407  568 GVGNWFARLWNYMRDEMAQVIRIRKVDDTEALLLSGDQGWFLRENVKLRMLNARLALLSRNEPVFRNDLAAAQAMIGRYF 647
194290489 671 DTKSRRVQGVLTLLRQAQAGAVTVQLPTMAESLGALQALKKE 712
17547075  654 DTQSPRVVAEQTLLQQARASVGALEVPTLGDSLAAARGQGKE 695
300703402 663 DPQSPRVVAEQTLLQQARASVGTLEVPTLADSLAAARGQGKE 704
300690777 656 DTQSPRVAAVQNLLQQARASVGTLEVPTLADSLAAVRGQGKE 697
187929643 661 DTQSSRVTTVQNQLSQARATVGTLQVPTLADSLAAVRGSGKE 702
241663751 624 DTQSSRVTTVQNQLSQVRAMVGTLQVPTLADSLAAVRGSGKE 665
113868874 666 DTKSRRVQGVLTLLRQAQAGAVTVQLPTMSESLGALHALKKE 707
94311680  652 DTRSRRVQGVLTMLKQAQASAVTVSLPTMAESLGALHALKKE 693
186476929 644 DASSKSVQTVRDLIKQIDEGSGAVDVPNLNTSLQAVHQYRNR 685
73540407  648 DTRSRRVQTVLTLLKQAQAGAVTVQLPTMAESLGALHALKKE 689
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