Conserved Protein Domain Family
DUF3527

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pfam12043: DUF3527 
Domain of unknown function (DUF3527)
This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 120 amino acids in length. This domain has a conserved CDCGGWD sequence motif.
Statistics
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PSSM-Id: 463443
Aligned: 28 rows
Threshold Bit Score: 354.337
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERN15943     237 TLSKGLIHCSWKDGLPHFVFSLDDSHEVLVAKPQRVEFSgekaLDFIYFFHLRSNGEKSQQKA-QK-----NSSNLIGKM 310
Q9LE58       274 VHLHCRLKMESKNGLPVFQFVSDSPEEVYAAKTWKSDNG----STWVYTFSSAGSRKRSSASVrGLtd-vsKESLLVAQM 348 thale cress
EEF51192     323 VHLHGCLKLDNKHGIPHFEFSLECPEEVLVAKTWKANNA----FNWVYTFHSISSRKKSNASGwGLid-gnKDSLVVGQM 397
KRH27923     319 VHLHGNLKLKNKQGLPFFEFKVKCPEDVFVAKTWKSGNA----FNWVYTFHSMDNRKKSTASDlGShy-cdEDSSMVAQM 393
KRH41175     321 VHLHGNLKLENKNGVPFFEFKVKCPKDVFVAKTWRTGNA----FNWVYTFHSIDNRKKSNVNGlGShd-fdKDPSIVAQM 395
XP_009389245 367 AHLHGILKLEIENGNPSFQFTLEDPEDVLSTKTWRTDTA----YNWVYTFHR--SKKK-MNTGrGTkdkhgQSPPLVGQM 439
XP_009400264 353 AHLHGILKLDIENQNPSFEFSLQDPEDTLSAKTWKTDSA----FNWVYTFHS--SRKK--NTNyGTkdkhgQSPPLVGQM 424
XP_018676333 281 SHLHGILKLETNSGNPSFEFHVKDPEVVLSAKAWRTDNM----FNWVYTIHS--SKKRNYNTWsRKidkhgQSPPIVGQM 354
XP_009390417 359 AHLNGILKLETVNGNPIFEFSVKAPEDVLIAKTWKTDNA----FNWIYTFHS--SNKK-INNNsRTkdqdgQAPPMVGQM 431
ERM95074     411 THLHGVLKLVHKHGVPSFEFSVKDPEDFLAARTWKVGNA----FNWLYTFHSNSSGKGRSSGGwGRke-rsKHSTIVGQM 485
ERN15943     311 TVSSRSN--PVESEF-----FDSNFVLYGAkedqvrcnmSKMASSSPYRS------WNKGAQKKAGNIFGT-YSRFQHSP 376
Q9LE58       349 QVTCKMCseVRKKGQdpetlMVNEFVLYDI---------AQARRSVSTKE------DQSLPLDTVNNASKNsVKSDSEIR 413 thale cress
EEF51192     398 EVSCYLCseLKDVGEfd-nsMVTEFVLYDI---------AHARQSVSTQD----------PADIIEPPSDFkPGSFCE-- 455
KRH27923     394 LVSSNSCskL-EGGVfd-nsIVTQFVLYDL---------THSSKHVSPEK------KCYSEQHCSKTLKAShGGMKGETF 456
KRH41175     396 LVSCNLCseL-EDKEfd-nsMVTEFVLYDF---------TQSRQSVSCEK------KSLSELDGSKTPKAFhVGSKEE-- 456
XP_009389245 440 QVSCHLCseVRENGSla-nsTVTEFVLYDI---------ARARCSFAVEE------RSKCSLDSIHSVASNaTEGLIT-G 502
XP_009400264 425 QVSCYLCseVKDNGSlv-nsTVAEFVLYDI---------ARARRHFVVEE------RSKCSSDSIQPVTSNaMGGLVAEG 488
XP_018676333 355 QVSCCLCseMRENGPaa-nsSVTEFILYNI---------VQAKRSFSVEE------SSECSLDATCPLQRNvMDKLVTEE 418
XP_009390417 432 QVSCFLCseVREKGSlh-nsIAMEFVLYDI---------AQARRSIMIDE------RSQCSLDSTHPLTSSvSTTSVKEK 495
ERM95074     486 KVSCYLCskRGIRDSld-ysMVTEFVLSDA---------THMRRDSEKEEipntcpSLKCSDQSVKAPESLvIGFPFEQG 555
ERN15943     377 LPKFRETNVKLK--ELNWENPLDASNKQDCLVIDNPLGENMLPNLELASILVKCHNSKKTGQeatiggwglkfleKTSVD 454
Q9LE58       414 NNSMSGDASDTMkqRSQPKRTSQSYDLEASNGTNPWSAANLHPDLEIAAIIIQDTIEKRESL-------------KYRRG 480 thale cress
EEF51192     456 TQKLNNGS-EPIklKHHSKRAFDTGNIDSSN-PYPWPSAVLHADLEIAAIVVQLPFAKRESL-------------KYKRG 520
KRH27923     457 RP-------DEEtlSTKNKLLSGNADFDNSN-SYPLSSTELHSNPEMAAIVLQIPFRKRESL-------------KYKRR 515
KRH41175     457 --TLGLHENRAVknKLQDKPLSSNVEFDDLN-FYPYLSTECYSNLENAVIVLQIPFSKRESL-------------KYKRG 520
XP_009389245 503 PLERS----IPVghPNPARHGFSCCDTNAST-SYPWLPEDLHPQLEIAAIVVQIPFSKTENL-------------KDIK- 563
XP_009400264 489 PYERN----NSVehPDSSRHGFGSSDSRPST-SYPWTPKDLHPRHEIAAIVTQIPFSKKDSL-------------KDMK- 549
XP_018676333 419 TLMPN----NLMkcQHPIRYTLSRYGSDDST-PYPWLPADLRPELEIAAIVIQTPFTKKECS-------------EEMK- 479
XP_009390417 496 HIGID----NSKehQNPTRNTCSSFRSDAST-SCPWSPADLHPQLEIATTIVQIPFDRRKGS-------------KGLK- 556
ERM95074     556 CG-------FETkwERPSRHGFGLGDSDGL--GKSFVPLGFQPHLEVAAMVIESPLEKRESL-------------KGKLG 613
ERN15943     455 GACNSPSQSKTNNlevvsfkncNESVSRNEGkmiAGMTVLVPAGFHGGPRTRNGGPSSLYERWES-GHCDCGGWDMGCPL 533
Q9LE58       481 DKRLMEKTNILGLspie--eekKELFGSRSL---EKLKVVIPRGNHGLPTTENSCPSPLIQRWRSgGGCDCGGWDMACPL 555 thale cress
EEF51192     521 DKSSDKAHRNLLNnsmnehgrkGGFTSRESP---EKLKVVIPTGNHSLPIDENQGPSSLLNRWRSgGGCDCGGWDMACPL 597
KRH27923     516 DRINAEAHSKLGDlssgvdqsrKSLHDRKVL---EQVKVVLPTGSHGLPSAESQGPSSLLDRWKHgGGCDCGGWDMACPL 592
KRH41175     521 DRISAKEYSNRSDlsav--kdrKSLHRHQIQ---EQVKVVIPTGNHGLPNAESHGPSSLLDRLRHgGGCDCGGWDMACPL 595
XP_009389245 564 -VFDLKENQNLSRlptd--dpgRETKNSLNP---AFVKVMIPNGPHGLPDTDDGGPSALLDRWRSgGGCDCGGWDMACPI 637
XP_009400264 550 -VSRPKESQNLSRspti--dqgRERKSSSNP---AMVKVVTPSGAHGLPDTVEGGPSSLLDRWRFgGGCDCGGWDMACPI 623
XP_018676333 480 -EVGPE-----------------GICNGLNS---AIVNVITPSGRHGLPNVDAGCPSTLLDRWRFgGGCDCGGWDMGCPL 538
XP_009390417 557 -EVTSKENQNLSSypav--dqeMEICCCLNP---ATVKVITPSGTHGLPNTDEGGPSTLQDRWRSgGGCDCGGWDMGCPI 630
ERM95074     614 DEREDAEECISMSgsctsdeiaSVIQNSNHG---ASMKVVIPSGVHGIPTDDASWPSPLLDRWRSgGACDCGGWDMACPI 690
ERN15943     534 TVMNLRERNDakvVIEVDTKEDCQSFELYIKGSKKGVPAVKLVNIHEGLYFIYFQSNLSALQSFSIGMAMIHAQ 607
Q9LE58       556 MVLGNPRISC---SHDQPLVENQHPLQLFVQGAKEHIPALYMSFVEEGQYDVHFHAQLSTLQAFSICVAILHNT 626 thale cress
EEF51192     598 TVFGSPSINC---AEDVLLIDNQQPLELFVQGTKQKIPALTMRIVEEGKYAVDFHAQLSTLQAFSICVAILHGA 668
KRH27923     593 ILLGNPSIQF---AEDRTLMEGYQTLELFTQGAKERTPTFGMTMVEEGQYAVDFHANLSPLQAFSICVAILHGN 663
KRH41175     596 ILLGNPTIQF---AEDCPLMEEHQPLELFVQGAKGSSPTFSMTRIEEGHYAVDFHAQLSTLQTFSICVAILHGT 666
XP_009389245 638 LVYNNPQADD---LIDHSTGKFQNPILLFVQGSKEKEPALSITADGEGQYSVDFHARFSSLQAFSICMAMLHSA 708
XP_009400264 624 VVFDNSHADD---RIDHSTCEIEKSTFLFVQGKKEKLPALSISADGKGLYSVDFHAQLSALQAFSICIAILHGS 694
XP_018676333 539 EVFHN---DD---WVYNSSMDTQKSILLFGQGSKEKAPALSITADGQ-QYLVDFHAKFSSLQAFSICIAILHGS 605
XP_009390417 631 VVFNNSHADD---WVDSQTFESRKSMFLFLQGSKEKVPALSIMADGKGQYLVDFHARLSTLQAFSICIAVLHGf 701
ERM95074     691 RVYENSSVNN---GARTSFEGNQSPLELFIEGGREKIPALSMKPLEEGVYAIDFHARFSALQAFSVCVAVLHAN 761
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