4DN5,4G3F


Conserved Protein Domain Family
STKc_NIK

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cd13991: STKc_NIK 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIK, also called mitogen activated protein kinase kinase kinase 14 (MAP3K14), phosphorylates and activates Inhibitor of NF-KappaB Kinase (IKK) alpha, which is a regulator of NF-kB proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. NIK is essential in the IKKalpha-mediated non-canonical NF-kB signaling pathway, in which IKKalpha processes the IkB-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus where it regulates gene transcription. NIK also plays an important role in Toll-like receptor 7/9 signaling cascades. The NIK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270893
Aligned: 6 rows
Threshold Bit Score: 480.085
Created: 12-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #####   #            # #                       #               ####
4DN5_A        69 YREEVHWATHQlrLGRGSFGEVHRMEDkqtGFQCAVKKVRlevFRAEELMACAGLtSPRIVPLYGAVREGPwVNIFMELL 148  human
4G3F_A        53 YREEVHWMTHQprVGRGSFGEVHRMKDkqtGFQCAVKKVRlevFRVEELVACAGLsSPRIVPLYGAVREGPwVNIFMELL 132  house mouse
NP_001026098 390 YREEVHWTKCHgsLGIGSFGEVYKVEDkqtGFQCAAKKVQvehFRAEELTTCAAItSPKVVPLYGAVKEGPwVTIFMKLM 469  chicken
CAG02785       9 YKEGREYVLSEf-IKDGSYGEVHSAQDvntGFKFAVKKIAmkrFNSEEVGAWSTLrSPRVAELFGVVREGPyVLLLMDLK 87   Tetraodon nigr...
CAG03027      10 YREGEEYCVLHh-IQNGSYGDVFCVRDattGFTCAAKRIPlrcFGLEEVSTWSVLtSPRVVELFGAVREGPtVVIFMDLK 88   Tetraodon nigr...
Q99558       393 YREEVHWATHQlrLGRGSFGEVHRMEDkqtGFQCAVKKVRlevFRAEELMACAGLtSPRIVPLYGAVREGPwVNIFMELL 472  human
Feature 1           # ##                                   # # ## #           #  #               
4DN5_A       149 egGSLGQLVkeqgcLPEDRALYYLGQALEGLEYLHsRRILHGDVKADNVLLSSDgSHAALCDFGHAVCLQPDGLGKD--- 225  human
4G3F_A       133 egGSLGQLIkqmgcLPEDRALYYLGQALEGLEYLHtRRILHGDVKADNVLLSSDgSRAALCDFGHALCLQPDGLGKS--- 209  house mouse
NP_001026098 470 egGSLGQLIkqsgcLPEDRALSYLGQALEGLEYLHaQNILHGDVKAENVLLSDDgSRALLCDFGHSAHLHPDGLGKC--- 546  chicken
CAG02785      88 a-GSLGQLItlrgrLPEDLGLHYQLQVLTALEYLAkKKVAHLDIKADNVLLSEDgRDTFLCDFGHAERLDNAGQSLSgsr 166  Tetraodon nigr...
CAG03027      89 p-ACLAQLLretssLPEDLALHYLHQTLGALEHLHnRKVLHLDVKVENVLLSADcRDTFLCDFGLSETVDDSGWSDQ--- 164  Tetraodon nigr...
Q99558       473 egGSLGQLVkeqgcLPEDRALYYLGQALEGLEYLHsRRILHGDVKADNVLLSSDgSHAALCDFGHAVCLQPDGLGKS--- 549  human
Feature 1                                   ####                                                 
4DN5_A       226 -------------------LLTGDYIPGTETHMAPEVVLGrscDAKVDVWSSCCMMLHMLnGCHPWTQFFrGPLCLKIas 286  human
4G3F_A       210 -------------------LLTGDYIPGTETHMAPEVVMGkpcDAKVDIWSSCCMMLHMLnGCHPWTQYFrGPLCLKIas 270  house mouse
NP_001026098 547 -------------------LVTGNYVPGTETHMAPEVVLGkrcDSKVDVWSSCCMMLHMLnGCHPWTQYYnHPLCLKIak 607  chicken
CAG02785     167 gkeiwsrfrggkqnmashiVFLQPDPKGSETHMAPEIVKGeprGAKADVWSSCCMFLHMLsGCQPWTRYYsCRLYLKIan 246  Tetraodon nigr...
CAG03027     165 -------------------AFRGGVFPGTETHMAPEVARGdplSSKADVWSSCCMLLHMLnGCRPWTRYYsHPLCLQIvn 225  Tetraodon nigr...
Q99558       550 -------------------LLTGDYIPGTETHMAPEVVLGrscDAKVDVWSSCCMMLHMLnGCHPWTQFFrGPLCLKIas 610  human
Feature 1                                                          
4DN5_A       287 EPPPVREIPPSCaPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGG 336  human
4G3F_A       271 EPPPIREIPPSCaPLTAQAIQEGLRKEPVHRASAMELRRKVGKALQEVGG 320  house mouse
NP_001026098 608 EPPPLREIPPSCnPLTAEIIKMGLEKEPVQRASASELRTKASTALQEVGG 657  chicken
CAG02785     247 DPPPLREIPPDCsHLTFEALKAGLQKDPAKRSSATDLKEKTARALKEVGG 296  Tetraodon nigroviridis
CAG03027     226 EPPPLWEVPSHCnNFTARVFRAGLRKDPERRASARALRRRTTKALRAVGG 275  Tetraodon nigroviridis
Q99558       611 EPPPVREIPPSCaPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGG 660  human

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