Conserved Protein Domain Family
Tcp11

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pfam05794: Tcp11 
T-complex protein 11
This family consists of several eukaryotic T-complex protein 11 (Tcp11) related sequences. Tcp11 is only expressed in fertile adult mammalian testes and is thought to be important in sperm function and fertility. The family also contains the yeast Sok1 protein which is known to suppress cyclic AMP-dependent protein kinase mutants.
Statistics
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Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam05794 is a member of the superfamily cl05390.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007329793        179 LRHDILFDSALQFRpAg----hRRKKENVERYWDAVAREIESgctcvsydtssrryipticvcdrvplptdapltftipp 254
XP_026235927          5 DLYVEEKDLP-PNSles--rfvETMYNAFWEHLHEQLSST-Pp------------------------------------- 43 
XP_002851076        188 LRIDVNFDRELHFQpiag-ekgHEKRKLAEAYWEAIALEISIhsyqstskkqqssp-------------rghkratsdsv 253
EFW20023            136 LRVDVNFDRDLYFHpveg-kkgEEKGRLAKLYWEAIAIEISIymyharslsgqss---------------nsgyqagelq 199
XP_002542386        136 LRVDVNFYRDLHFRpveg-ekgEERDRLARVYWEAIAIEIAIyayhaatnnsecg---------------eygyrannfq 199
WGS:ABKH:PAAG_07613 132 LRMDVNFDNDLHFRpv----ggPAKLKVADEYWRAIAIEISIyafctshninfsl----------------dldssppih 191
EDN09078            132 LRMDVNFDKDLHFRpv----ggPVKAKMANEYWHAVAIEISIftfgaynnidlsf----------------wvrnashsh 191
EEQ87804            132 LRMDVNFDKDLHFRpv----ggPAKAKMTNDYWQAIAIEISIfnfgasnsinlf-----------------fgarrsssc 190
EHK48977            130 LRHDINFDPELHFRpNidgekgRRKHEKANQFWRALKQELSEflmdrptf-------------------------iykhg 184
EHK24505            136 LRHDINFDPELHFRpNldgekgRRKQDKANQFWRTLKQELSEfiidrptf-------------------------iykhg 190
XP_007329793        255 syiTVRTPSRVRALLNEFLEVLLHVI-QplatlsgpyvksevlqgpveeHAEQAKHIRSLFDLDLIEQELKHGVFDPSGL 333
XP_026235927         44 ---DFSCALELLKKVKEILLSLLLPRqNr--------------------LRNEIEKALDMDLLKQETEHGALNVYHLSKF 100
XP_002851076        254 gvfE----PRLPVMLETLKDVVSSLV-----------------------PERDQQSVMQNLDVPFLLQQVHKGVLDMINL 306
EFW20023            200 ayfE----PRLPRFLETLKDVLWSLV-----------------------PERDHQIITESLDVPFILQQIEKGVLDLVGL 252
XP_002542386        200 gffE----PRLPLMLETLKDVLWTLV-----------------------PERDHQTIAENLDVPFIMQQIEKGVLNLVSL 252
WGS:ABKH:PAAG_07613 192 qvfQ----ARLPKMLDILREILLTLV-----------------------PERDCQCVKENLDISFLMKQIEKGVLNLVEL 244
EDN09078            192 kvfR----ARLPNMLDTLREILLTLV-----------------------PDRERSCIKEHLETKFLVAQVEKGVLNLVGL 244
EEQ87804            191 qvfQ----ARLPNMLDALREILLTLV-----------------------PDRDRVYIKEHLDTKFLMTQVEKGVLNLVRL 243
EHK48977            185 ekdD----WTLPILLNAVKDIIQTLV-----------------------PQRDRLFLDEGLDVKLLMRQFHKGVADLEKL 237
EHK24505            191 dsdE----WTLPILLKAVKDIIQTLV-----------------------PQRDRQFLDEGLNVELLMQQFHKGVADLEKL 243
XP_007329793        334 FQVIGLTLKNHCAPMRDHAVDSMVeAAKacapggsatiRdAVKVVRNCSEILELMKLDIANHQMQTLRPFLVYSSGAFER 413
XP_026235927        101 ILDLMSLLCAPVRDEAVQNLKSIT-DPV----------Q-LLRGIFHVLGLMKMDMVNYTIQSLRPYIQEHSVQYERAKF 168
XP_002851076        307 TKWLATLLKTHCAPMRDPWADKMVaEITegct--tgntYkMVEGLRTMFGTLESMKLDVANHQIRAFRVILIDDTVRFLQ 384
EFW20023            253 MQWLSKLVKAHCAPMRDELANKMVnQVQegle--lqdvCkTVQGLTLMFSVFECMKLDVANHQIRTFRLFLINDTVRFLQ 330
XP_002542386        253 LEWLSALVKSHCAPMRDSLADQMVdEIRegne--lrdpRrTVNGLTIMFGILESMKLDVANHQIRSFRLPLIDDTVRFLQ 330
WGS:ABKH:PAAG_07613 245 AEWLATLLKTHCAPMRDHMADEMVkHIQtgcq--lqdmNeIAEGLKQLFAILESMKLDVANHQIRSFRVLLIQDSIEYLT 322
EDN09078            245 AEWLAVLLKTHCAPMRDQMADDMVeQVRngyq--lqdmNqVSKGLHQLFVILESMKLDVANHQIRAFRLYLIEDSVEYLR 322
EEQ87804            244 AEWLAILLKTHCAPMRDHMSDDMVeHIRngcq--fqdmNeVSKGLHQLFAILESMKLDVANHQIRAFRLYLIEDSVEYLR 321
EHK48977            238 AQWLSNVLKSHCAPMRDEWVDAMYnQLSngnk--nmdlDeLVTGMRSLLNVLEAMKLDVANHQIRCLRPALIEDTIHFEQ 315
EHK24505            244 ALWLSRVLKSHCAPMRDEWVDTMYnQLSngnr--nmdlDeLVTGMRSLLSVLEAMKLDVANHQIRCLRPVLIEDTTHFEQ 321
XP_007329793        414 KMLR---SRR---SidPSLPLTKEWLRFAhtTFSSQEEPIKYPSQPQGlRYTSLGKKH---------QLYISVVRSIVDM 478
XP_026235927        169 QELL---DKQpnlL--NYTTKWLTKAAID--LTTPFPSSDSPSFSSSI-EYSSSDQEPnnpelpsltMVLYQGYLNLLLW 240
XP_002851076        385 SDLK---KRIaanT--IDIQQARRWYLDI---CHRPLY-----KSPYLqHELKG--SY---------APIALLFIGLFSY 440
EFW20023            331 TYFQ---RRIsenT--IHTEGAKKWF-------HAVLKD----EQASRrRWTRHWTEF---------DNVVTVYRGLSQF 385
XP_002542386        331 SYFF---HRLdenA--MYVEEAKKWF-------HNALR-----EQACLrRWTRGWTEC---------NNVAAVCRGLTPL 384
WGS:ABKH:PAAG_07613 323 KYFHfsmKKSpktF--REAQDARDWYLGY---RR---------LERYQnNPQIVLNNF---------ESAKVLFEGLFSI 379
EDN09078            323 KHYDfviKKSqqsL--KEAQNSKNWYIMH---RR-----------RCNlSSQQVPNNF---------ESAKILFEGLSSI 377
EEQ87804            322 KHYDffiKKSmksS--SEAQNSKIWYFVH---WR-----------EFHtDSEPVHNDF---------ESAKILFEALSLN 376
EHK48977            316 KFFL---KRMesgK--TDISMSRQWYKEA--------------EQAYAdSRMHPTQSF---------GDMGVFFEGLSRL 367
EHK24505            322 KFFI---KRMesgK--TDISMSRQWYKEA--------------EQAYTdSRSHPSQSF---------GDMGVFFEALSRL 373
XP_007329793        479 VFDppSssSPSLvtttlpsppsdlpfpsFPETLYLDQARIQTYTSEIADLVALWMFLLLYRQLISSFGHRkyq------- 551
XP_026235927        241 GHG--Ne-EFPE----------------TLLMDRIRLQEMESKLHHLTILASVLLVARSFSGSVLFSSPE---------- 291
XP_002851076        441 LVPfeHpkR-------------------FQDIFEFEADRLWFIRADIQDLMGLEICSRVFE--------Lvaieqg---- 489
EFW20023            386 LIPfnPpgG-------------------LPATFEFHTDRLWTLRSDIQDLIGFELCTYVFD--------Lvatshm---- 434
XP_002542386        385 LSQsdSpaG-------------------FPATFKFTHCRLWMMRSEVQDSIAFELCKHVFD--------Ktasnhi---- 433
WGS:ABKH:PAAG_07613 380 LCSfgSpkW-------------------FPKTFQFDIDRLCNIQDNFETLVLLQVCYQVFN--------Aavrriy---- 428
EDN09078            378 LCSfdRtiR-------------------FPDSFALDFDRLYNIRNNIETLALLQVCCHAFN--------Svvg------- 423
EEQ87804            377 LCSfcQp-P-------------------FPDSFALDFDRLCNIRTNIETFTLLRLCCQAFT--------Mvvn------- 421
EHK48977            368 MLPsaWeeR-------------------LPTTFTFDEERLMKLRADVLDAINLEVCMRVYEDFERIGRRTpaapssdcss 428
EHK24505            374 MLPsaWdeR-------------------LPNTFLFDEERLMKLRSDVLDAINLEVCMRVYEDFDKMSRRSspaapssdga 434
XP_007329793        552 -------------------------------------kerINEFASI-----------LKREIRAIGPRSLHTCflecsn 583
XP_026235927        292 ----------------------------------------FVDKIKY-----------ITKALTEEFNSRPEETm----- 315
XP_002851076        490 -----------------------------------rhspyYQQAKSA-----------IPSRIFCILDDCPNGIsadfda 523
EFW20023            435 -----------------------------------rhvarTRETYVS-----------LRSHIWSIIECSGHQDpa---- 464
XP_002542386        434 -----------------------------------phiprSREVYST-----------LRSRLWSIVE-GDRNGa----- 461
WGS:ABKH:PAAG_07613 429 -----------------------------------geisfCTSTYIS-----------LQSRILSVLKYGDYQSveth-- 460
EDN09078            424 -------------------------------------gdvSSTIYCS-----------LQSRILSIIQYGEHATcend-- 453
EEQ87804            422 -------------------------------------gdvSAALYYS-----------LQSRILSILQYDEHTPhend-- 451
EHK48977            429 qvddildrfdfntpp-sisrpssvvhsvagsasssprssfVVPSYVApkrdsqtkareLFQTLVALLQTSPQAS------ 501
EHK24505            435 shvedimdrfdfntppsvsrpssvvhsvagsasssprssfVVPSYVAprqdsqtkareLFSTLVALLQTSPPSS------ 508
XP_007329793        584 s-sgsnqnPTTdklksalDNVVLQIARRassiQRGQElP----EIGALPsmtddipskFTVSvARKWVDANMKL----HS 654
XP_026235927        316 --------QNV-------SEQVSEEIHK----GLKNM-G----LTALSS----------ENTaSLIGQLQNIAKkgncIR 361
XP_002851076        524 rhanpsspNANhkwqnnmSLIALEIAQS----LCSLDgSn---KGNTFPd-------kRTLDsVEKYLEFFFTSp---TG 586
EFW20023            465 -------iFDEqkwcdnvSPIALEIARI----ISNLEaNskgiKTSVVPd-------eHVLLfVERMLESCFDPr---SQ 523
XP_002542386        462 -------iIDAqkwrnniSSIALEITRL----ISNLEaSi---KPGVTLd-------aNVLSyVEGMLRSCFGRr---SP 517
WGS:ABKH:PAAG_07613 461 ----ppgnCAIdrfqgniLNIALEIARV----AHIMQdRh---CGATYPd-------eNTIDfASSMLRSLLWFk---DA 519
EDN09078            454 ----psghPLIarfeanmQNIALEIARV----AQMMRgEr---SLVTYPd-------eRIIHfVSNQVHPr-------HR 508
EEQ87804            452 ----vsghSLIarfeantPSIALEIARM----AHMMKeGs---SLVTCPd-------tRVIHfISDQLSPr-------NR 506
EHK48977            502 --------QPStrwqmmaPSMALQIFRF----VN-------------LPs--------TTLPhLEAKLASALSDi---DS 545
EHK24505            509 --------QPSarwqmmaPSMALQIFRF----VN-------------LPs--------TALPeLEARLSAALGDv---DA 552
XP_007329793        655 SLRKLlhgrLKKvvfervladvyparseaalekmmgkeiegwgevllpskdclgialpksaipfsdnkapaqedgmgngl 734
XP_026235927        362 CIIEQ----RIHlflkcclvrgmqeslld-------------------------------------------fpggllfi 394
XP_002851076        587 -QSRE----FSLsvqrdleeatfgyvkkylqmtplems-------------------------edqrpreypdpknytfs 636
EFW20023            524 -QFKH----FQMvvqqrleeatlaaaeryvdmspl------------------------------emcedqhpsqpddsl 568
XP_002542386        518 -LFEH----YREvvseqlekatmavieryvgmscl------------------------------dmcddqhlpqpedyv 562
WGS:ABKH:PAAG_07613 520 -QFWD----IRDciqqelqsitiefaeqywsmtalg-----------------------------vadsqnlgrsydhms 565
EDN09078            509 -HFEA----VRDrvqqelksialntakqywrmsale-----------------------------iadsqhlhqqpdfvs 554
EEQ87804            507 -PFEA----VRQcvqrelkniavnfasqywhmtald-----------------------------iadsqqfeqrsdyvs 552
EHK48977            546 PYYRD----AEEsfltrlmadlgarvrefkglsgvalfsvat----------------gvrvpsrrpatadrdtdggsre 605
EHK24505            553 CFYRD----IEEnflgrlmadlghrvrefkglsgvslfsvat----------------gvrvpsrrpgsadreadghlre 612
XP_007329793        735 emlsdevqSLVEKISLLVVVHFNAYLP-VYEKEEF 768
XP_026235927        395 dgelaelgWKFITLMHHNQQVFSPYYT-EILNNVI 428
XP_002851076        637 qrllldvdGIAKRLAHIGVLHWRVWAPiLYLHEGP 671
EFW20023            569 qlqpkdidSIGKRLAHICVLHWHIWGPiLYFRDLP 603
XP_002542386        563 qlgpndieSIGKRLAHLCVLHWRVWGPiLYFANSG 597
WGS:ABKH:PAAG_07613 566 lpqipdiqCLGKRLAHIGLLHWRVWAPlIYSPEDG 600
EDN09078            555 wpqipdiqWIGKRLAHIGVLHWRIWAPlLYSPEDG 589
EEQ87804            553 wpqvpdiqCLGKRLAHIGVLHWRIWAPlLYYPGEG 587
EHK48977            606 afddasvdDIATRMAHLGVLHWRVWSQlAYADDDQ 640
EHK24505            613 pydeasldDIATRLAHLGILHWRVWSQlAYADDVD 647
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