Conserved Protein Domain Family
RT_Bac_retron_I

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cd01646: RT_Bac_retron_I 
RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA branches out from a small ssRNA molecule via a 2'-5'phosphodiester linkage. Bacterial retron RTs produce cDNA corresponding to only a small portion of the retron genome.
Statistics
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PSSM-Id: 238824
Aligned: 65 rows
Threshold Bit Score: 61.1911
Created: 3-May-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activeputativeputative NTP
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based primarily on the structure of the stalled complex of HIV-1 RT bound to NTP and DNA primer-template (1RTD).
  • Citation:PMID 9831551

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ######                                                                         
YP_419823    230 ADIANFF--GSIRHDVLFAMLarriadptmlelcrrlvfqdvr--------------qgaivqdaagtlarvpshkslFQ 293  Magnetospirill...
ZP_00580485  136 LDIYSYF--NSINKKELLTQLynliynsnlsalrqyclanliekiieq----datklqnertgdqyllnqiplhkklqFN 209  Shewanella bal...
YP_900686    527 LDIKGFY--SNIDREMLRIKLvdgptdeirvafkslget----------------------eidkikvlaswfisicdAT 582  Pelobacter pro...
NP_811226     41 LDLRGYF--MSIRKDRLYDLIckgleryrrsrkqkecpdmelidfllrq-iifrnpqrdcrirgsaedweglpptkslFN 117  Bacteroides th...
ZP_01236470  112 LDIYSYF--NHINKARLKDRLvalietppqsigqfhpvkkhillylieqilqqdaarennlqtnnhrllaqipphkrlSF 189  Vibrio angustu...
ZP_00120811  128 LDVRKYY--PSIDRTTLKAMLtrdvgdpil----------------------------------------lrlvfhliDR 165  Bifidobacteriu...
YP_212908    212 LDIQRYFysVRIDLDSIKNRCshsnkqiekcfhllqiin---------------------ktytskinklldipltndEL 270  Bacteroides fr...
YP_125450    221 LDLENFF--HNIDPSFLSSEAfvkeligdlsedeaefnv----------------------qmsqflkrwsdkasslfDK 276  Legionella pne...
ZP_01555949  136 LDVRDFY--PSIPHALLRAQVttrlkshkavalle------------------------------raietptvsvadkSK 183  Burkholderia a...
YP_277064    150 TDIQKFY--DSIDQDRTVMLVgrkikipqvlnliaha--------------------------lrtptvpkntprnkhSV 201  Pseudomonas sy...
Feature 1                ##                                               # ##                   
YP_419823    294 TPAGIGLPIGNlsSQFFANVYLDPVDqmvkr------------------rlklrYVRYVDDMVIVHQDPKvl----laAA 351  Magnetospirill...
ZP_00580485  210 NTQQVGLPIGSvtSQLFGNFYLNNLDheikht-----------------lkvkgYVRYMDDLFILSDSPEkl----qqWK 268  Shewanella bal...
YP_900686    583 VEGKKGVPQGPafARYLAELYLMDFDrfiermv---------------sgslgrYFRYVDDVFVFVDTEAea----asIL 643  Pelobacter pro...
NP_811226    118 SPEGVGLPIGDltSQLFSNIYLGELDgyvkrv-----------------lrckhYGRYVDDFFIVHPSKRylkelipwIR 180  Bacteroides th...
ZP_01236470  190 SQQGVGLPIGSvtSQMFGNFYLNDLDhfckht-----------------lkikgYIRFMDDLIVLSDNIAql----kiWK 248  Vibrio angustu...
ZP_00120811  166 YQGGNGLNIGSylSQWLANYYLSHAYhwiespamtierisrrtgeitrrrlithQLWYMDDLLLIGTSKRdlkiaarrIV 245  Bifidobacteriu...
YP_212908    271 NAGYTILPIGLlsSGLLGNLYLEDFDktikee-----------------lnpayYGRYVDDILFVFSDRKvklevnnpIH 333  Bacteroides fr...
YP_125450    277 KPFKGGLVVGLtaTRVISNIILYKFDklvkek-----------------itpihYGRYVDDLFLVILDPGnvrn-iveFM 338  Legionella pne...
ZP_01555949  184 AAVAVGVPQGLaiSNLLAEIFLHPFDtavas------------------kvnvaYFRYVDDVFVLTSEPPa------pLF 239  Burkholderia a...
YP_277064    202 YKQEVGVPQGLaiSNILAAIYMADVDramrs------------------vpglhYYRYVDDVLMYGEESLvt-----tSF 258  Pseudomonas sy...
Feature 1                                                                 ##                     
YP_419823    352 DAIRAHLsg-------lGLHLAEs-----KTFVAPVEKg---------------VDFVGHVIr--------------pHR 390  Magnetospirill...
ZP_00580485  269 EHIEWYLts------hlQLKLHPt-----KVHLAPIEEg---------------FDYLGFRVf--------------pHY 308  Shewanella bal...
YP_900686    644 AYATNFLks-------lGLHLSHg-----KCFVGTIAQy---------------KPEISRYFsrakyvvdhaklqtdhSG 696  Pelobacter pro...
NP_811226    181 EFLKEEL----------ELELHPd-----KIELQHYSRg---------------AAFLGAYVr--------------pYR 216  Bacteroides th...
ZP_01236470  249 NHIDAFLkq------qlLLTLHPh-----KTKIKVIEHg---------------VDYLGYTVy--------------pHY 288  Vibrio angustu...
ZP_00120811  246 HYLKDRL----------GLDVHEew--ncKRLDLEPIDmvgytfrphgrvnirsGVFLRARRt--------------fSR 299  Bifidobacteriu...
YP_212908    334 DFIDRYFikk----nilETILDEn----nITYLLPVGSh---------------KLKIQSEKvile---------hfnHK 381  Bacteroides fr...
YP_125450    339 DYLKNRLgedylsngneKWSIKLg-----KDYQKKSIFq--------------fQTEKQRLFvlegq------agcdlLD 393  Legionella pne...
ZP_01555949  240 EELRSALes------dfGLSVHPvgtdgsKSTFGLVTNe---------------FTFLGYLFr--------------vGK 284  Burkholderia a...
YP_277064    259 NSLKRRLmr-------rGLHLHGls--sdKTKFGPLDQd---------------FSYLGYVFe--------------lPK 300  Pseudomonas sy...
Feature 1               
YP_419823    391 RSARPKT 397  Magnetospirillum magneticum AMB-1
ZP_00580485  309 KHIRKTT 315  Shewanella baltica OS155
YP_900686    697 KITNAIT 703  Pelobacter propionicus DSM 2379
NP_811226    217 KYPSKRT 223  Bacteroides thetaiotaomicron VPI-5482
ZP_01236470  289 KTIRPST 295  Vibrio angustum S14
ZP_00120811  300 AARRPMN 306  Bifidobacterium longum DJO10A
YP_212908    382 ESRAAIN 388  Bacteroides fragilis NCTC 9343
YP_125450    394 SIEKEIK 400  Legionella pneumophila str. Lens
ZP_01555949  285 ARVKEQS 291  Burkholderia ambifaria MC40-6
YP_277064    301 ITVRRNT 307  Pseudomonas syringae pv. phaseolicola 1448A

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