Conserved Protein Domain Family
Phage_holin_2_1
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pfam04971: Phage_holin_2_1 
Bacteriophage P21 holin S
Phage_holin_2_1 is a family of small hydrophobic holin proteins with one or more transmembrane domains. Members of this family fall into the holin superfamily II, and Phage 21 S holin is the prototype for this superfamily. It has two transmembrane segments with both the N- and C-termini on the cytoplasmic side of the inner membrane in E. coli. Holins are a diverse family of proteins that cause bacterial membrane lysis during late-protein synthesis. It is thought that the temporal precision of holin-mediated lysis may occur through the build up of a holin oligomer which causes the lysis.
Links
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Statistics
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PSSM-Id: 428228
Aligned: 8 rows
Threshold Bit Score: 67.8855
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q32F12        5 DKISTGIAYGTSAGSAGYWFLQWLEQVSPSQWAAIGVLGSLLLGLLTYLTNLYFKIREDKRKAA 68  Shigella dysenteriae Sd197
KQN56739      5 DKLTTGLAYGSSAGSTGFWVLQLMDQVTPSQWAAIGVLGSLGFGLLTYLTNLYFKIKEDRRKAA 68 
OIV47672      5 SDVAAGLSYGTSLGSGGYWLLQLMDTVSPGQWSAIGVLASVFFGLLTYLTNLYFKIKDYRRKRH 68 
WP_025796664  5 DKITTGISYGASGGSALFWLKQLLDGFSPEQWAAFGVLGSLLFGFLTFLTNLYFKVKEDRRKAS 68  Hafnia alvei
WP_067431676  6 SKLASGAAYGASAGTI---ANGLLTCLSPDEWSAVGVLAGIVVALITLGINWYYKRKATLAQIK 66  Erwinia gerundensis
WP_042395855  5 SKLVTGVALGTSGGTI---LNGVLTKLSPDEWSAVGVLAGIAGIIITGLVNWYFKRKVTNAQVK 65  Pseudescherichia vulneris
EGG93491      3 EKIAVTTSYGASATSI-------VAGLSSAEWSVVGIVGGLIIGVATFFVNLWFKLEQLKIDRE 59 
KMV69644      5 GKISSVVSYCASGSLICWG--SVMDKIHHLDWQTISVVGGLVIGVITCASNFYFKRRQTRAYES 66
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