Conserved Protein Domain Family
SAV4209
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cd03455: SAV4209 
SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and gamma-proteobacterial members of this CD have, in addition to a hot dog fold, an N-terminal extension.
Links
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Statistics
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PSSM-Id: 239539
Aligned: 18 rows
Threshold Bit Score: 134.367
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activeputative
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on the active sites of (R)-hydratase and the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          #    # #  #               #  ##                              
NP_825386     4 GEELPPLEIEVTRTLIVAGAIASRDYQDVHHDAESARRR-GSPDIFMNILTTNGLVGRYITDHFGpgAVLRKVAIRLGAP 82  Streptomyces ave...
YP_116658    17 GTTLPELVIHADPTFVISTAIATRDFQDVHHDRDKAVAR-GSKDIFVNILTDTGLVQRFVTDWAGprAVVKSIALRLGVP 95  Nocardia farcini...
ZP_00656906   4 GDPLPEWSLPLTPTTIVSTAIATRDWQDVHHDRDVAQAA-GSKDIFMNILTSNGLVERYVVDALGpdTELKGIAIRLGAP 82  Nocardioides sp....
NP_960395    12 GDHIPTLTVTVDETQMFFFSAATYNGHRIHYDKEWARAE-GYDDVLVHGALQAALLARALGDWIGgrGRLVSFSVQNRAV 90  Mycobacterium av...
ZP_00278782 155 TDATWRRLIEPDETLLFRYSALTFNAHRIHYDRTYVTQVeGYPDLVVHGPLQAALLADLVQRHLPg-RAFETFLFRAVRP 233 Burkholderia fun...
CAI85967     15 GDKLPEKAIPITVALISNGALATRDFFPGHHDKDAAIAL-GSPHIFMNILTTNGLVQSYVEGWSGpqSRLKNIDIKLGMP 93  Pseudoalteromona...
ZP_00509298 176 QGAAWQREIVPDDVLLFRYSALTFNGHRIHYDRRYVTEVeGYPGLIVHGPLIATLLVDLVRRHVPg-AFVKSFSFKAVLP 254 Polaromonas sp. ...
ZP_00277313 162 EGEMWRRTIDADPVLLFRYSALTFNGHRIHYDSPYVTQVeGYPGLVVHGPLIATLLVDLVRREQPd-ATFQSFAFKAVRP 240 Burkholderia fun...
ZP_00597842 166 HTAQFGRSLKADPVLLFRYSALTFNGHRIHYDLDYVRDVeGYPGLIVHGPMQAMLMLELLRHERPd-ARVKRFGFRGLAP 244 Ralstonia metall...
ZP_00568039 256 GVALRRYHKHPKWAFRDPNTHALEPVYSVHYNDYAARLQ-GAQIAYDVGIQRTCWQIHSLTSWMGddGTLKALHGQYRSH 334 Frankia sp. EAN1pec

Feature 1                                                        
NP_825386    83 NYPGDTMVLTGTVVEVEgd-----taTVKVIGANGIGTHVRG--TVTVT 124 Streptomyces avermitilis MA-4680
YP_116658    96 LYAGDTLTLTGTVTEVSdt-----dvTIAVVGRDSLGDHITA--TAVIG 137 Nocardia farcinica IFM 10152
ZP_00656906  83 AYPYDTLTFRGEVTGVEdg-----iaTIAVVGSVSLGDHVTG--TVRVA 124 Nocardioides sp. JS614
NP_960395    91 AYPGEPLSFGGRVTGKRldes--gsgLVDLDIAGRRDDTVLMpgTATVQ 137 Mycobacterium avium subsp. paratuberculosis str...
ZP_00278782 234 LFLGQPFSVCGRPAADGs--------TVELWVSDHEGALTMSa-QATLA 273 Burkholderia fungorum LB400
CAI85967     94 NYPGDVMTFMGEVTATDatt---rtvDVGLAGKNKYGMHVTG--TVQLV 137 Pseudoalteromonas haloplanktis TAC125
ZP_00509298 255 TFDLHPFRLHGQPSADGk--------TVKLWAADHEGWLTMQg-TAELA 294 Polaromonas sp. JS666
ZP_00277313 241 TFAGQAFTVCGKPSADGk--------VIDLWAKDHEGCLTMRa-TAALA 280 Burkholderia fungorum LB400
ZP_00597842 245 LFHLDTVTVGGMDDAETp-------gKVILWTGDDAGGQAMAg-WAEVE 285 Ralstonia metallidurans CH34
ZP_00568039 335 VYLSDVVRLGGRVVAKEidadgdhvvRVETWATNQRDTNVMPg-SAVIA 382 Frankia sp. EAN1pec

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