Conserved Protein Domain Family
DUF4503

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pfam14951: DUF4503 
Domain of unknown function (DUF4503)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.
Statistics
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PSSM-Id: 464397
Aligned: 16 rows
Threshold Bit Score: 480.711
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EHB08835     244 QDAYGIFGEVHLEYAVLT-------DRELEGHSCSLVGLKVLQKATRGRTPGLFSLLDTLWPPVMPLKGSGYSEP-CKEV 315 
XP_008113073 552 QDVYGMFSEIQFQIPFSSpepieeySKRWEGRHCLLSGMKVLQRVVRGKVLGLFSLIESLWPPQLPLKVPGRSQE-NNVI 630 
XP_014345423 152 QDAYGIFSEVQLLTFCSSdeelqqhTRKWEGKSCYLTGMKVLQRTTRGRSPGLFSLIDSLWPPLAPLKVHGRSQD-SQEL 230 
XP_014327418 527 QDSFGIFSVVRLQPLSSKdel-hqyCQMWQGRTCVLTGVKVVQRVTRERHSRLFSLIDSLWPPATSLKDHGNSLSmLNEI 605 
4_pfamImport   1 QDGYGTFSVVQLHLLPRSddl-hryCRQWQGRTCLLRGIKVVQRVTRERSTRLFSLIDSLWPPAVPLQDHGDTASmSPES 79  
Q14159       521 QDACGMFGEVHLEFTMSK-------ARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQP-CEEI 592  human
XP_008253725 520 QDACGMFGEVHLDGALLK-------ERQLEGKPCNLAGMKVLQKATRARTVGLFSLIDTIWPPVMPLKAPGRGQP-CEEV 591 
XP_021586718 105 QDAYGMFGEVYLEGAMLK-------GRQLEGKSCRLAGMKVLQKATRGRTPGLFSLIDTIWPPAIPLKAPGHSQP-CEEV 176 
Q8BGX7       540 QDACGMFGEVFLNSTLWK-------SRQLEGKSCSMSGVKVLQKATRGRTPGLFSLIDSLWPPVISLTEPSCGQP-SGET 611  house mouse
TNM98559     531 QDSYGMFSVVQLHLLPCKddl-hhyCHMWQGRTCLLRGIKVVQRVTRER-------------------------C-SRLF 583  Takifugu bimac...
EHB08835     316 KTHLPPPAFCYI------FSAHPSleHIDITEEDPMSKLYQ------------------------------------PPV 353 
XP_008113073 631 TADMPPPSFCYI------LVAPFGqrHIEVDEGEQISNWYF------------------------------------PPT 668 
XP_014345423 231 DTCLSAPSFCYV------LSPHAEegCVEPLSEDSLSALYL------------------------------------PPV 268 
XP_014327418 606 SSPGPPPSFCYL------LSGHRR--SVEPREGQTVSPLYL------------------------------------HPA 641 
4_pfamImport  80 RSAAVAPRFCYL------LSGQES--SVEPTGDRTASPLYL------------------------------------PPT 115 
Q14159       593 KTHLPPPALCYI------LTAHPNlgQIDIIDEDPIYKLYQ------------------------------------PPV 630  human
XP_008253725 592 KTHL-PPTICYI------LTALPNlgQIDVIEEDPLSKLYQ------------------------------------PPV 628 
XP_021586718 177 KSHLPPPSFCYV------LSVHPNlgQIDMIEGDSISKLHQ------------------------------------PPI 214 
Q8BGX7       612 KTYLPPPIFCYI------FSAHPTlgQIDAIE-DHISKLYQ------------------------------------PPV 648  house mouse
TNM98559     584 SLID------SLwppvmpLRDHRT------------PPSTSsetraagsapsfcyllsglessvqpaegpplsplycPPT 645  Takifugu bimac...
EHB08835     354 LHCLREILWTHHLGARCSFYARVIYQRPQLKSLLLLEQREIWLLVTDITLQtknQSGPHLP--KTLPVCVAPSCMLCPEI 431 
XP_008113073 669 VQSFKEILQTSKLHQCCSFWAHVVYRRLQEKRSTLSSQTQSWLFVTDFSLQrkvEVGPGIP--KILPISVASTCMVDGEV 746 
XP_014345423 269 VHTLRDILQVVGSSHRCSFSARVVYRRPQIPSICDSKQREWWWFVTESSLQsdpDCASRVP--RVVPVCITAPCLLGTDL 346 
XP_014327418 642 SRTLRDILHSEAKSCCCSFIATVLYKRMQ---STDVGRGEVWLVLTDPSLQe-eQPERPCR--RTVALCVSTSCVLTSSV 715 
4_pfamImport 116 KQTLRDAVQSPRQTRRCSFVATVLHKRKT--QGRDVGQGEVWLLLTDAGLQe--ERRPEGPcrRTVALCVSTSCALTSSV 191 
Q14159       631 TRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTLQtkeERDPRLP--KTLLVYVAPLCVLGSEV 708  human
XP_008253725 629 SRCLREILQTDNLGTRCTFYARVIYQRPQLKSLLLLEQREIWLLVTDITLQgkdKSDPRLP--KTLPICVAPSCVLDPEV 706 
XP_021586718 215 LHCLRDILQTDNLGARCSFYARVIYQRPQLKSLLLLAQKEIWLLVTDITLQmkdGNDHHLP--KILPVCVTPSCVLGPEI 292 
Q8BGX7       649 VRCLKEILQTNECSTRCSFYARVIYQKPQLKNL--LAQKEIWLLVTDITLQtqdERDHSLP--KTLPVYIAPSCVLGPEV 724  house mouse
TNM98559     646 MQSLGDILQTDVKSFRCSFAATVIYTRLT--QGSDVGQGEVWLVLTDPSLQeekEEKPERPcrRTAALCVSTSCVLTSSV 723  Takifugu bimac...
EHB08835     432 LEALTMGTPLNIFFKDALRDQGRIVCVERTVLLL----------Q-KPLLCVASG-ADSCE--------------LTGPV 485 
XP_008113073 747 MEALKSTSPCVVFFKDAVYGNGRIICIERTVLLL----------Q-KPLLCRAAD-ADITK--------------LPGPV 800 
XP_014345423 347 ISALNDGFSGAVYFKDAVRQNDTVICAEHTVLSL----------Q-Q--LSNVDG-VDLGQ--------------LSGPV 398 
XP_014327418 716 LEALNSPAVCEMSFRDAIREHGVLLCAEQSVIEVysvqpkssfeT-TTRQDSLSS-SEPQVk------------tLPQPL 781 
4_pfamImport 192 LESLNSPAPCRMSFRDAVREHGRASCAEQSVVE----------------VCSVDPeSEPRAe------------aLPRPV 243 
Q14159       709 LEALAGAAPHSLFFKDALRDQGRIVCAERTVLLL----------Q-KPLLSVVSG-ASSCE--------------LPGPV 762  human
XP_008253725 707 LEALIAAASPSILFRDALQDQGRIICVERTVLLL----------Q-KPLLCVASG-AASCE--------------LMDPV 760 
XP_021586718 293 LEALSTAAPHSILFRDALRDQGQIVCVERTVLLL----------Q-KPFWGMASG-AGSCE--------------LTGPV 346 
Q8BGX7       725 VEELALLVSYNLLFRDAFKDNGQIVCIERTVILP----------Q-KPLLCVPSA---SCD--------------LPSPV 776  house mouse
TNM98559     724 VRALKSSAACQASFRDVIKEHGVLHCVEQSVIEL----------CsQSSRRPECV-AESSAgagslsrslteptiLPRPV 792  Takifugu bimac...
EHB08835     486 TLDELDSFTPVNSICSVQGTVVGVDESTAFSWPVCDQCSNGRLEQRPEHRGAFSCGDCSRVVASPILKRHLQIFLdCPAR 565 
XP_008113073 801 ELDELDSATQANSICTVRGVIVGVNEKTAFSWPTCNRCGNGKVEQRPQDRGLLYCNQCCEAIISPVVKMHLEVFVrCPSR 880 
XP_014345423 399 KLDGLDSTTKVNTLCTVKGTVVGVDESTSFSWPTCNRCGSGKLERSQTNRSPLYCCQCSRAVTTPVIKMQLEVFMhCPSR 478 
XP_014327418 782 RLDSLSLETAPNSLCSLTGVIIGVNENASYSWPACNLCGSDNLEVSAEKPQNFHCISCKSALDKPDTKVQLEVFLsSSSL 861 
4_pfamImport 244 RLDPLTAEVTPNSVCSLSGVIVGVDETTAYSWPACNRCGSDNLEMLPERRPNLRCVPCESPVDEPDTRVQLEVFL-SSSL 322 
Q14159       763 MLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLdCRSR 842  human
XP_008253725 761 MLDELDSLTPVNSICSVQGTVIAVDEDTAFSWPVCDRCGNGRLEQRPENRGAFSCGDCSRIVTSPVLKMHLQVFLdCPSR 840 
XP_021586718 347 ILDELDSLTPVNSICSVQGTVVGVDENTAFSWPTCDRCGNGRLEQRPEDGGTFFCGDCCELVTSPVFKRHLQVFLdCPSR 426 
Q8BGX7       777 TLDELSALTPVNSICSVQGTVVDVDESTAFSWPVCDRCGNGRLEQKPEDGGTFSCGDCSQLVLSPLQERHLHVFLdCPTR 856  house mouse
TNM98559     793 RLDPLVPEVTPNSLCSLTGVIVGVDEDTAYSWPVCNRCGSDNLEILAGGNGSFQCVSCESVVDQPDTRMQLEVFL-SSSL 871  Takifugu bimac...
EHB08835     566 PHCSVKVKLLQSSISSLLRFAAFK---DGSYEVKSVLRKEVGLLSCFVQSITTRPTSC-IGLEEIEL 628 
XP_008113073 881 PLCTVKIKLLQKSISSLLGSSPAE---DGSYEMKNVLGKEVGFLYCYVQSVTNHPSNC-VGLEEIIL 943 
XP_014345423 479 PHGTIKVKLLQGSISALLMSSSID---DGCYEVDSVLGKEVGPLSCYVRCITSQPTSW-IGIEEICL 541 
XP_014327418 862 SNCTLKVKLQQKTIMSILNTPVLEsseLQGYDVESVLGKEVGPMAVYVRVVTRKPAQW-MGLEEICL 927 
4_pfamImport 323 SNCTLKVKLQQKTIASILNSAALEaheFPGYDVEKVLGKEVGPLAVYVRVVTRKPALW-IGLEEIWL 388 
Q14159       843 PQCRVKVKLLQRSISSLLRFAAGE---DGSYEVKSVLGKEVGLLNCFVQSVTAHPTSC-IGLEEIEL 905  human
XP_008253725 841 PKCRVKVKLLQSSISSLLSSATCE---NGSYEVKSVLGREVGLASCFVQSITTHPTSC-IGLEEIKL 903 
XP_021586718 427 PQCSVKVKLLQGSISSLLRFAACE---DGTYEVKSVLGKEVGLLSCFVQSITTHPTNF-IGLEEIEL 489 
Q8BGX7       857 PESTVKVKLLESSISLLLMSAASE---DGSYEVESVLGKEMGPLLCFVQSITTQQSSCvVTLEEIEL 920  house mouse
TNM98559     872 NDCTLKVKLQQETIVSILNATALEgadSAGYEVESVLGAEVGPLAVYVRAVTRTPALW-MGLEEVSL 937  Takifugu bimaculatus
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