Conserved Protein Domain Family
AIF-MLS

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pfam14962: AIF-MLS 
Mitochondria localization Sequence
This family contains a protein found in eukaryotes. Proteins in this family are typically between 240 and 613 amino acids in length. The family is found in association with pfam07992. This protein family is an N-terminal domain for the mitochondrial localization sequence for an apoptosis-inducing factor. The protein is also known as Corneal endothelium-specific protein 1 or as Ovary-specific acidic protein. It is thought to be important for membrane function and is expressed in the ovary and corneal endothelium.
Statistics
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PSSM-Id: 464407
Aligned: 10 rows
Threshold Bit Score: 217.389
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001103026   1 MYLRRAVSKTLALPRRAPPGPAPLGKDASLRRVSSSKFPGPSGSNMIYYLVVGVTVSAGGYYTYKAFTSKQVRHTEHVTD 80 
XP_003899250   1 MYLRRAVSKTLALPLRAPPNPAPLGKDASLRRMSSNRFPGSSGSNMIYYLVVGVTVSAGGYYAYKTVTSDQAKHTEHITD 80 
ELW69172       1 MYLRRAVSRTLALPLRAPPSAAPLGKDASLRRMSSSKFPGPSGSNMIYYLVVGVTVSAGGYYTYKAVASEPAKHTEHVTT 80 
XP_005327629   1 MYLRRVVSKTLALPLRAPPNPAPLGKDASLRWMSSNKFPGTSGSNMIYYLVVGVTVSAGGYYTYKTVTSKQAKHTEHITN 80 
XP_004768551   1 MYLRRAVSKTLALPLRAPPGPAPLRKDASLRWMSSNKWFGSSGSNMIYYLVVGVTVSAGGYYTYRTITSEQGKQTERVTN 80 
XP_006906278   1 MYLRRAVSKTLALPLRAPPSPAPLGKDASLRWMSSNKFPGSSGSNMLYYLVVGVTVSAGGYYTYRTVTSEQARHTEHITN 80 
A6QLZ1         1 MYLRRAVSKTLALPLRAPPGPAPLRKDASLRWISSNKFPGSSGSNMIYYLVVGVTVSAGGYYTYKRVTSGKAKRSDHVTD 80  cattle
XP_014310672   1 --------------------------------MSSNKSPGSSGSNMIYYLVVGVTVSAGGYYTYRTVTSEQVKHTGHIKN 48  little brown bat
XP_003790221   1 MYLRRAVSKTLALPLRAPPSPAPLGKDASLRRMSSNKFPGSSGSNMIYYLLVGVTVSAGGYYTYKTVTSDQAKHTEHITN 80  small-eared galago
XP_023409003   1 MYLRRVVSKTLALPLRAPPGSTPFRKDASLHRLSSNKLPGSSGSNLMYYLVVGVTVSAGGYYTYKAVRSEQARHTEHTTN 80  African savanna...
NP_001103026  81 PKEQTKAELQPLPGETEHVAEAGKA---------------CSETGEISVKESDSVDAEEVPEAAAVL-PEESQASASevP 144
XP_003899250  81 LKEKTKAEIHPFQGEKENVAETEKA---------------SSEAPEVLAVEAEVVDAEESPGATVVV-IKEASACPG--H 142
ELW69172      81 LKEKTKAELHPLQGVKGNVEEAEQA---------------GFEVPEVSAVAAEVEGAEGLPGATAES-TPEDRPCPG--G 142
XP_005327629  81 LKEKTKAELHPLQGEKENVAEAEKA---------------SSEALEVSVVQAEVVGAEEIAEAAVG--DVEESAGPG--D 141
XP_004768551  81 LKEKNKAELHPLQGEKENVAGAEKA---------------SSDVCEVSAPEVLEVDAEGTPDVPAAA-VEEASAGPG--D 142
XP_006906278  81 LKEKTKAELQQLEGEKENLGGAEKA---------------SSEAPEVSSVEAQVVDAEEIPDATVAV-ITEASACPD--T 142
A6QLZ1        81 LKEKTKAELQPPQGEKENLVGAEEA---------------SLEAPEVSSTEASPVVTEDIPDAPAVV-GKEAPPCPD--D 142 cattle
XP_014310672  49 LKEENKAELQPLQVEKENLEGAEKA---------------SSEAPEVSSEEAQVVDAEESSDAAAAGrAEEASACPD--A 111 little brown bat
XP_003790221  81 MKEKTKAELHPLQGEKEHIAEAEKA---------------SPEAPEVSVVEAEVVAAEEIPDATVAA-LTEASACPG--G 142 small-eared galago
XP_023409003  81 LKENNKAELYSLQGEEENAVEAERAsaeapevsvveaekpSAEAPEVSVVEAEVVGTEEVPSATDAV-IEEDLACPE--G 157 African savanna...
NP_001103026 145 AEAALvETSVLSSEPELKITddhDASPVETTEGVPESPPEVEGAAPDQADVCS 197
XP_003899250 143 VEAAP-ETTAVSAETGPEVT---DAAARETAEVNPETTPEVTNAALDEAVTID 191
ELW69172     143 VEAP-----AAGVEPASEGT---DTATGETTEVDSEESPEVPSAAPGDAVAIR 187
XP_005327629 142 VEATKeEVTAVGAEMEPKVT---SAQTGDTTEDGSEMTPEATDVAASEGISTC 191
XP_004768551 143 VEATAgEPDAVSAKVGAEAT---DAGLGATAEASAEAPPEVQSAALDGAVAGN 192
XP_006906278 143 AEAAPvETTAVSAETGPEVP---NAATGETAEVSIQTTSEVTNAALDEAVAID 192
A6QLZ1       143 AEAAPsETVVVGAEPKPEMT---DAATVETTEVSTETTSEVTSTGPEEAAAVD 192 cattle
XP_014310672 112 AEAAPvEITAVGAETEPEVP---NVTPCESAQVSTGATSEVTSAAPDEAVAIS 161 little brown bat
XP_003790221 143 VEAAP-ETAAISAGTTPEVP---EAAMGDTTEVSAGTTPEVTDPTLGEAVAID 191 small-eared galago
XP_023409003 158 GNAALvGKAAVGAETGLEGT---DAPTGETTKVDAEATQGVTEAAPYEAVAHS 207 African savanna elephant
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