Conserved Protein Domain Family
Cas10

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COG1353: Cas10 
CRISPR/Cas system-associated protein Cas10, large subunit of type III CRISPR-Cas systems, contains HD superfamily nuclease domain [Defense mechanisms]
CRISPR/Cas system-associated protein Cas10, large subunit of type III CRISPR-Cas systems, contains HD superfamily nuclease domain is part of the Pathway/BioSystem: CRISPR-Cas system
Statistics
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PSSM-Id: 440964
Aligned: 145 rows
Threshold Bit Score: 107.532
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_009992992   74 DKLassidrylgsivykeyslfrnrsiflknillsniqrdvgnlfpkdkskldnliseykkllnv--------------- 138 
WP_010977942  205 lgklinprhhvaeainileklqnklksgeaciklervkelvashhgdsesivqiadrlassadrltklvnealehieygk 284 
WP_011278844  201 ehhvresvdileevlrkstgelcikggiekirdevlhhhgqiqtilnmaddvaashdrispivmegldnlnlsvkecysk 280 
WP_015738992   46 DKAarfwakeyyelvfplrldapevekidgsvnfrsrkqdpgfppilpapgsrvtetlladavvirtallnlllrqrkve 125 
WP_015051494  195 DAYtaasllagypeel---------------------------------------------------------------- 210 
WP_015128920   57 aqrlyntfedltpktvnelkekddylklwedktriglvyggatkikqyvfeaaklpdirgasalldrinlvdlraffgdy 136 
WP_015176590  184 DDLadaiekrytee------------------------------------------------------------------ 197 
WP_015224777  239 Dp------------------------------------------------------------------------------ 240 
WP_087457138  171 DR------------------------------------------------------------------------------ 172 
WP_107806700   49 dlvpqveelqnfdfpqtvaqlkdltekypqlwnseiglvyggatkikqyvfeasklpeirgasalldrinlidlpaffgc 128 
WP_009992992  139 -----------tnttnlnilkyqlfyliyeliwidsryentpaetrnpthtifdhlyataammnwifslekeaKGYLLGI 207 
WP_010977942  285 eikecfnkereesyecftnlgkekyekaskdiykfilsqvisleivkneeakvfpfipekverssneikpvrpIGYLVYI 364 
WP_011278844  281 rgedsfncleskgaqeyekaskelykylssvlldpsviqkdeakvlkylndvkpaqtpkstqqasanttsrnpIAYLVYV 360 
WP_015738992  126 kellnavrlaslvsplaeelakhllswpkevelllsafqgrapfprdvdgdlvravseavfsplevqslpdelGVTLVIG 205 
WP_015051494  211 ------------------------------------------------------------vpgitatswdhlpPLELVVG 230 
WP_015128920  137 neqdsslvenikrwldtnfpnlrkalipeliiystggsilafcpaafvddlanaiekrythetltanscavgdTFKLLEF 216 
WP_015176590  198 --------------------------------------------------------------tltanscavgeKFKLLEI 215 
WP_015224777      --------------------------------------------------------------------------------     
WP_087457138  173 -------------------------------------------------------------------------KFAIVKA 179 
WP_107806700  129 ennleypqcqrtqtycqevrkkwldksenfpglskalipeliiystggnilafcpsafvddlanaiekrytgetltansc 208 
WP_009992992  208 DTIGVADFISKGKKTRDLWISSYLVSALLWYVITWFI----EEYGP-----DVILFPSlrfnqfyafylleklrkekise 278 
WP_010977942  365 DVPSIQRFITNFPKLRDMSFASMLVDFLVTVYSFMLIdtefVSKTKsrlpaEALLSGY---------------------- 422 
WP_011278844  361 DFPGIQKFITNFPGLREMSFASFLVDFITSVYAFALIdskfRDLGKsmlpvEALLSGY---------------------- 418 
WP_015738992  206 AVQRVKQYVFASPGLNEIRGASALLDEITESLERDVE----SELGV-----EVLLRAA---------------------- 254 
WP_015051494  231 GAFKVKEYYLETNRIGEIRGASVLLDDINRKRFFRMF----RELPGlt--gASLIYAG---------------------- 282 
WP_015128920  217 RFGLLQDKIE----------DTFWFDKYEKNQDNPIIr---AYFDQs--------------------------------- 250 
WP_015176590  216 RFGLLREAIE----------NTLWLEWYRQHYQKPLLq---AYFGNl--------------------------------- 249 
WP_015224777  241 -----------------------------------IIe---SYYGKv--------------------------------- 249 
WP_087457138  180 GAVKIKQYLLESNKIQEIRGASRLLEEISREYVPQFLr---EAVTP-----ESVVYSG---------------------- 229 
WP_107806700  209 avgdkfkllevkfgllpnaitnetfwlekcvnnweenplikAYFEQp--------------------------------- 255 
WP_009992992  279 dvideikelitkyifnGDdlfekleippypiipgRITLILpgliregeEytqvpDDNYFIS----KVKERYNEGWRKLie 354 
WP_010977942  423 ----------------GGh---------------SYIVVRkdi--cdgDcy-------------kKIKDIFKGIKl---- 452 
WP_011278844  419 ----------------GGh---------------SYIVVRadl--dkpD-----------------IEGLFKNLKl---- 444 
WP_015738992  255 ----------------GS----------------RLEFLVp------dE-----EEGEYWRk---KIKQRFFERT----- 283 
WP_015051494  283 ----------------GG----------------HLLAVVp------------aGKGEMVAg---EIERLYREVCLTAra 315 
WP_015128920  251 ------------------------------------------------Ev--------------nDPFERFQN------- 261 
WP_015176590  250 ------------------------------------------------EknlenSKTERCTeepiSVEDAFAN------- 274 
WP_015224777  250 ------------------------------------------------Dek-------------tDLKQNFYN------- 261 
WP_087457138  230 ----------------GG----------------NILLLVp-------E-----EQGKRVAe---RIENMYREMTGSAqa 262 
WP_107806700  256 ------------------------------------------------Nk---------------LPEKAFKE------- 265 
WP_009992992  355 glkcyselkredgfwnlvcrvlkLTEDLlqttplNIRVKQVSVtkDeifnnsklrsdsWKIYDNKYRQLVSEFKKSKLvk 434 
WP_010977942  453 ------------------------LSDLd----lRLQVSVAEFayd----------nyIKNYNEVWDEIRQQFSERYLvd 494 
WP_011278844  445 ------------------------EEELd----aKLNVTVLDFmyd----------neILGINKISEEIGKQSYNRYLld 486 
WP_015738992  284 ------------------------GSSL-------VATAASSVkiKkl----------lTEFQEVLRRANRELEKERNlv 322 
WP_015051494  316 vgv----------------scrvHAAEL-------------------------------SDFSSLNRRLNDEIVDRRSvl 348 
WP_015128920  262 ----------------------------------------------------------RKNFNELVGKLANQFTQRRNgn 283 
WP_015176590  275 ----------------------------------------------------------RKSFNEITTKLAVMFNQRRSgn 296 
WP_015224777  262 ----------------------------------------------------------RKSFNELVGKLTSLFNQRRSgn 283 
WP_087457138  263 ---------------------vaFPATVt---------------wGdi---------dTSNFASTLSWIEQKKTERQMam 297 
WP_107806700  266 ----------------------------------------------------------RKTFNELAGKLASLFNQRRNgn 287 
WP_009992992  435 vtpesr-----------lklfeltkFdklpq-------igekSKRGYEF------------C-------------TSCGV 471 
WP_010977942  495 fe------------------------------------ekiySVGLHRV------------C-------------DNCGI 513 
WP_011278844  487 fn------------------------------------erlySYGLHET------------C-------------SYCGI 505 
WP_015738992  323 fpva------------------------------------gealpfEER------------C-------------SICKK 341 
WP_015051494  349 ipawdaekgdielyadgslnvssfpL----------------PDAGGRW------------C-------------DSCGI 387 
WP_015128920  284 htp-----------------------------------------------------nrpsrCyppifethpyvqrDESDR 310 
WP_015176590  297 dfs-----------------------------------------------------nrpsrRyppmfethpylirDGNER 323 
WP_015224777  284 rhe-----------------------------------------------------trpsrCyppmlethpylvrDSSDR 310 
WP_087457138  298 gtnf---------------aaavnvQdkerpyeptdlhtyleSVQKAEQdtaflllqnkaiC-------------ISCRL 349 
WP_107806700  288 -----------------------ilLgnnr----------------------------plrCyppmfethpylvrDESDR 316 
WP_009992992  472 LPAViimpkedefekklielgiardekdvrsiknmispGER----LCPWC----------LVKRalgaeprlmRilllgd 537 
WP_010977942  514 RPAVne------------------------------klGEY----LCSRCy---------EIREls------sT------ 538 
WP_011278844  506 RPAVddvpi-------------------------spdeKER----LCKRCk---------LVREls------sN------ 535 
WP_015738992  342 RVAEgwy-----------------------------qtpEKqlepACRVCytkre-kgreLRCR---------------- 375 
WP_015051494  388 RPAVkqwk---------------------------yedeERp---LCASClrkq--ivgqSARK---------------- 419 
WP_015128920  311 RSAImkve----------------------------fpnSRf---LSEPLarkr--lvgeIAKRes-------------- 343 
WP_015176590  324 RSAItrvqp-------------------------pklprETn---FSETSarkh--rvgyRAKKdlr------------- 360 
WP_015224777  311 ASAMtqvt---------------------------tlasEPy---FSEPTarky--vtgqQAKRdn-------------- 344 
WP_087457138  350 READtyik---------------------------rngvQA----LCTACfqkvqmgnsqEEER---------------- 382 
WP_107806700  317 RSAVikae---------------------------glpnEPw---FSESLarkr--ivgqIAKKdh-------------- 350 
WP_009992992  538 lcsvekivneivskdvkIEIPSTSDIASIk------TFEEMIEKKNE-------------IcedlKEEEVCekpnesmls 598 
WP_010977942  539 -----------------RGFISKVNSTYL------------------------------------LSVEvtp------ee 559 
WP_011278844  536 -----------------RGFSAKTDTTYM------------------------------------IDGSFirp-----ad 557 
WP_015738992  376 ------------------------------------MVEKLGEEV--------------------VDREVFv-------- 391 
WP_015051494  420 -----------------TVFaadyref----------------------------------------------------- 429 
WP_015128920  344 ----------------sRAWYDDAKLEwepf-dipsWVNKFEKFINKkdnqqlanlyygaVnk----------------- 389 
WP_015176590  361 ---------------qvPEWYEESQLEwnpg-viegWVARFDRFLEKnpslkq--kyyggL------------------- 403 
WP_015224777  345 ---------------snLEWYDKLGLDwqpg-evesWVKKFETFLERsdyfq---syyqdC------------------- 386 
WP_087457138  383 ------------------------------------FLREMIDVsqqy---------rptL----KAPNL---------- 403 
WP_107806700  351 ---------------nsRKWYDQAGFDwepgdeietWVNKFEFFLHQtphk-----yygkI----RSEKI---------- 396 
WP_009992992  599 MWQRFNKNyytginLTIDP---Ee--yWFSEKRRRYyfslfrrhritFPSPYYALVRADSDYLGDLLEGKltpylagiid 673 
WP_010977942  560 IAKEVFGdnya--------------eyaMEFIAGYkkl---------edTRYVSIIKADGNRGSIIFSASa--------- 607 
WP_011278844  558 LAKSIFKG--------KDSsegeylnyaMEFIAGWkne---------ndKKYISLVKADGNYAGIIFSATv--------- 611 
WP_015738992  392 --------------RLEPPd-------SLNELPPEN-----------LAHKWVAVVYGDGNNFGGVLQQKid-------- 431 
WP_015051494  430 --------weargvQADLPaa-----qEISEIADSN--------------EEIAVIYADGNNFGSLFGQCn--------- 473 
WP_015128920  390 ---------------------vEea-rSLREIASAS-----------TPSGFVAYIYADGNNMGGYIRQKik-------- 428 
WP_015176590  404 -----------------KSdnvEia-eNLSHIGNAS-------------KNFIAYIYADGNNMGGYIQNIr--------- 443 
WP_015224777  387 -----------------NPdeiTea-rNLEEIANAS-------------NDFISFIYADGNNMGRYIQKIr--------- 426 
WP_087457138  404 ----------------QVPk-------DLDDIAGAK--------------GQIAVVYGDGNNMGKVVERLd--------- 437 
WP_107806700  397 -----------------HPdrvKea-iSVREIGDAS-----------ITPGFIAYIYADGNNMGGYIQKEik-------- 439 
WP_009992992  674 sgdyanisekkeevnklleeylvnagsgpivdyvktvlecirgnlnkcscavkiysnevaevmfranrllrkklekidve 753 
WP_010977942      --------------------------------------------------------------------------------     
WP_011278844      --------------------------------------------------------------------------------     
WP_015738992      --------------------------------------------------------------------------------     
WP_015051494      --------------------------------------------------------------------------------     
WP_015128920      --------------------------------------------------------------------------------     
WP_015176590      --------------------------------------------------------------------------------     
WP_015224777      --------------------------------------------------------------------------------     
WP_087457138      --------------------------------------------------------------------------------     
WP_107806700      --------------------------------------------------------------------------------     
WP_009992992  754 revenslkyfrtilkegriivtPAWHVSISSALNRGLLVELEL-INk-----------------------HKGFVIYAGG 809 
WP_010977942  608 ---------------------tFSDYVDKSFRLDYGVKRAFYEtLIelanaemelsk---sakgllltsrVLSGVLYLGG 663 
WP_011278844  612 ---------------------tFSDYVDRSFRLDYGIKKAFYEtLKelheketssana-qsstgnslvprVLSGVLYLGG 669 
WP_015738992  432 ---------------------kLASALQWTQRIKRVTWKAAAQaLReamnsee----------asrelkrLPFQMLLLGG 480 
WP_015051494  474 ---------------------sLAHLRMLSQFTENAAYTAAFTaIKehqal----------------ldngAVEIIALGG 516 
WP_015128920  429 ---------------------tPQDYRLFSEDIFTATEKSVYKaLAqylhpyqytpdakssrtnkepvwiHPFEIITIGG 487 
WP_015176590  444 ---------------------tPQKYQEFSKDVELATEYAVYQaLAeslhphelqnftdedstlsngdlvHPFEIITIGG 502 
WP_015224777  427 ---------------------tPEAYQQFSNDIFEATEQSVYYaLAqhlsphqlgtlkkpeskyraekwvHPFEIITIGG 485 
WP_087457138  438 ---------------------sLTQFRYFSVLFDQVTRLATYTtVVec---------------------nTKCEVIAVGG 475 
WP_107806700  440 ---------------------nPQDYQNFSRDIGEATENSVYAaLTkhlaphkinptlqaerksdqdvwiHPFEILTIGG 498 
WP_009992992  810 DDLLAMLPVDEVLDFVKESRRAFAGVS-TGrLgnmclengfar---------------------innayypslpiVGRSY 867 
WP_010977942  664 DDITLLVPSIVAIPFAVKFFEKATQLT-G----------------------------------------------FTFKV 696 
WP_011278844  670 DDIMLMSPSVIAIQFAVRLFKKAQEYT-G----------------------------------------------FTFKV 702 
WP_015738992  481 EDISLFAWGPVGLHFARYFVELTDREF-APaqdv--------------------------------------kerISFSL 521 
WP_015051494  517 DDAFIIVPAQAALPLAVAIGKCFDRLF-KNlSegk--------------------------------------agPTLSV 557 
WP_015128920  488 DDVLLVVPANKALEISKAIGDEFEDILwRTdryslqqttpnllah----------------ryttgnippaskclLSMST 551 
WP_015176590  503 DDIFLIVPADKALAIAQTIGQRFEKILlKQqplvenstateqikgdyqiqrsnkpidkkkihrykpteappsqcqLSTSS 582 
WP_015224777  486 DDVLLIVPANKALEIAKTIGEKLEEILvKKgrytiepdpnsvsa-----------------hryspeaatpsqceLSMSI 548 
WP_087457138  476 DDVLLILPATYALRAARIIGEKFDQAL-DT-Yeeq--------------------------------------egMTISF 515 
WP_107806700  499 DDVMLIVPADKALAIAKTIGEEFEKILlSKgkvykedkkydpqkvh--------------ryqvkdeiygdkqckLSMST 564 
WP_009992992  868 SVIIAHYADPLFFVINDSYN-LLEEGKemir------yrvmYNGeykdaKKDVAIFRYQ----GlT-------------- 922 
WP_010977942  697 GIVSVKPDHPIQFAFQAADE-LMERSKikpedgisstknlseYN-----KTSIACMVFSstlaS-Ksvv----------- 758 
WP_011278844  703 GVLTVKPDHPVQFAYQAVNE-LMERAKighl-------ngspVA-----MSSIAAMLFSnslaN-Rnvi----------- 757 
WP_015738992  522 GVLVTDEKAPVFRTLNFTEEeLLKWAKraar-------ergyKR-----GGTIAFFLAPs--aD-Qipgdlenflrra-- 584 
WP_015051494  558 GVIIAGAKTPVRYLFEVAQA-LLKEAKkray-------rdlaKGel--kEGTLDIAVLAs--yG-Ayednitvyrs---- 620 
WP_015128920  552 GVLITAQDTPIYYADKLVSQ-LLKSAKkyak------elkkDHKy---yGGTVDFLVMKavtmissnikefreq----gl 617 
WP_015176590  583 GVLITAYDTPIYYAKDFLDQ-LLKSAKerak-------klksAGy---cGGTVDFMVMKsvtmissdvkvfrk------e 645 
WP_015224777  549 GVLTLGYKTPIYYAQNLANQ-LLKLAKkrak------dlkqHYHy---yGGTVDILALKsvnmissnipdfr-------d 611 
WP_087457138  516 GISIGAAATPFAILFRTASD-LLTSAKqvkk------qnksTWR-----GGSLDFQVVRnaslG-Egiqeerkllfqkrs 582 
WP_107806700  565 GVLITADDTPIYYAEKLTEQ-LLKSAKkqak-------elkkKHy---yGGTVDFLVMKsvtmissnisefrte----gl 629 
WP_009992992  923 ------------SVIPLSLkrpivn---------svsdfNEiasIIdlilelkKRIDEGh--------ISVSLL---YDY 970 
WP_010977942  759 ----------hsEISKYKRqnnsylvv-----tndirkvKE---LLelak--lyeFKDVvslyn-sendKKEVReklRQL 817 
WP_011278844  758 ----------dtEINKYSGskhneikykflvvsnplenvEE---FLksfg--ledFKELvnlynnereGRNKVKevlRPI 822 
WP_015738992  585 flkpgkvmnlclTLRPLSA--------------------EElgfLIdk----aRELRS----------YSGSLL------ 624 
WP_015051494  621 --etfckngvklTLRPYTFtq-----------------aEN---LMka-------------------------------- 646 
WP_015128920  618 iknkdgqsklklYASPYTL--------------------YElggLLet----aKAFKKAe--------FPRSQL---YQI 662 
WP_015176590  646 alfkklkpnlklYAAPYTL--------------------HElggLLss----iEALNKAk--------FPKSQL---YQI 690 
WP_015224777  612 nalqtqdqkrhlYATPYTL--------------------HElggLIat----iQAFQKAe--------FPRSQL---YQI 656 
WP_087457138  583 qdryqnpilvhqLMRPYSFt------------------qSR---MMea---wiKELQKTn--------GSRSIL---YHM 627 
WP_107806700  630 tkftnkqqklklYAAPYTL--------------------HElggLWet----aKALKNAe--------FPRSQL---YQI 674 
WP_009992992  971 EEYKHl--IVASDEKy----LT-----EFLVKdw---ikRNSLRKHveftiDEKLYGVRltienypikipnDLIsNIVYT 1036
WP_010977942  818 EDivsyaetnfntsngylktlayilrqiarsdkpydkeilkklverkegslkeiplydyyfilktfrvgvg--------- 888 
WP_011278844  823 QDVVGylsTINKENKgsediFF-----KGLAYmv---rqRARVKE--------NQSNTD------------SQR-KVLST 873 
WP_015738992  625 -RLATa-------------fIKgspkvATLLYlyq--kgRKKEKELf----DELEKIEKvp---------pTLC-ELMFP 674 
WP_015051494  647 -------------------------------------lcRlqtsreipgrswfyglrqaavsygmqvanlffnyqfsrlp 689 
WP_015128920  663 RSLLErgk-----------------rtAILNYryf--riRLTNEAAkqelkkqfesawcqpkessnngnlapwmslqetn 723 
WP_015176590  691 RSFLErgk-----------------htAILNYryf--rtRLQQgksgllehfeeawcqpkdptnpgnlapwmyddgslet 751 
WP_015224777  657 RSFLAqgk-----------------kiSMLNYryf--avRLSEQNNqq-llRDKFE--Qpwcqa--ktnngNLApwmfds 712 
WP_087457138  628 RDVVQnl------------sVEe----SKLHYyyymltnRESNEQR-----QKVHQWIEthp-------ieGFQnDLLYY 679 
WP_107806700  675 RSLLEqgk-----------------qtAILNYryf--rvRLSDKKAqe-llEKQFE--Kawcqp--ksnngNLApwmslq 730 
WP_009992992 1037 ---------------------LRIIY 1041
WP_010977942      --------------------------     
WP_011278844  874 llqntkis-----ndggsaplYDYYF 894 
WP_015738992  675 tffsserkvfgtdaqkegsyhFSALV 700 
WP_015051494  690 eaqqkalrncwhiltgqhgdpamfce 715 
WP_015128920  724 sqdannskmtyetiwrelvdlypfia 749 
WP_015176590  752 dksdyplfetiwrdmvdlydfiaase 777 
WP_015224777  713 qq------------giyetiwNDLID 726 
WP_087457138  680 kkqddhve-----avqlyspwHDLVE 700 
WP_107806700  731 eee---------dkvsyetiwRELVD 747 
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