7APK


Conserved Protein Domain Family
efThoc1

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pfam11957: efThoc1 
THO complex subunit 1 transcription elongation factor
The THO complex plays a role in coupling transcription elongation to mRNA export. It is composed of subunits THP2, HPR1, THO2 and MFT1. The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm.
Statistics
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PSSM-Id: 463412
Aligned: 45 rows
Threshold Bit Score: 210.318
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7APK_A       128 AIISLAIGG--------VT--EGICTASTPFV-LLGDVLDCLP---LDQCDTIFTFVEKNVATWKSnTF----------- 182
XP_011276267  94 TLLDFSFYIr----------kIGESLYDMPYE-LIKGVLKEGLv--D-WLLKFWSYFDLRIEEIKrtkdn---------e 150
XP_002618753 119 LILDLAMWM------------TQEHIRVTDFHsLLQTVVDSLSkfsTDTVSVFWTYMESRESAFLAhVFdr--------- 177
CAR25145      83 VIMDLCHHLgr----lrGEdsARKLWITTYFE-LFKQALSFLCl--PRGHLKFWPYVETRMHWFQS-GYapevkyg--qt 152
Q6CKD4        86 VLLDFCYHLky-----vGEedESKVWAALFFD-LTATCILTLTf--PHELGQFYTYLRSRLSWYLE-GLskepvsnggtn 156 Kluyveromyces l...
Q750X0        90 AVLD-CVHWmqa---geGAagDAAAWANLYFD-LTKSAMQFLAv--PDGFLAFWPYFESRLAWYLQ-GQdvvpvrsgenr 161 Eremothecium go...
XP_003646123  97 VILD-CVHAiqcsskhrGDasWAGTWANLYFD-LTKIVMQFLQf--PSSFLSFFPYFESRLQWYLQ-GQemeqfsygdnk 171
XP_004177699 166 lLLDLCFLSr-------SKrqNPSLWYRSFFQ-LFSTVVDLLIw--PNELLQFWEYPQSRIEWFKLlGDpssqlpl-gts 234
EDO19313      99 VVLDFVYHSr-------KNrkIPGNWGSTFFE-IFSHCLNLLSw--PSEMLDFWPYTESRIEWFKM-GNslnpvey-gst 166
XP_003684683 102 VLLDYRFLAk-------ESwsDPKTWATSYFN-LFSKILDLLNw--PYQVSEFWPYVESRITWFKIgNNlinenefgsnt 171
7APK_A       183 ----YSAGKNYLLRMCNDLL------RRLSK-------SQNTVFCGRIQLFLARLFPLSEKSGLNLQSQFNLENVTVfnt 245
XP_011276267 151 tlvcLRHPGSSLLITINLRI------NQLYGnh----ePSRDILKAKLLGFTSKIFPAFDKSLINKNFEFNQAHLNTvqy 220
XP_002618753 178 ---kITSHRVAMLAICNGLTdqyykrRKTGKldsyekdTFNDNLQSRVRTFLSSLLAFDDSTGLNKYFTIANRANREphl 254
CAR25145     153 nlsaIKAPFSKITFHINKLL------STMREqsk-lstPLHYKLGMKIHWFLSQCLSPMEQANTNRRGNFA-KSLPE--- 221
Q6CKD4       157 lkmgIRPPAAKLFFSIDTFF------KNIDShsl-fitPNHFELVHKLLWWISQLIPINDHCNINRRAKIT-DEYPE--- 225 Kluyveromyces l...
Q750X0       162 lvsgIRLPLSRLLYHCNELV------RQLEAqsk-lntPRHYMVAHKLQWFMSQLLPASENCNYNKSGELM-AQLPE--- 230 Eremothecium go...
XP_003646123 172 ltsgIKLPLSRLLYYCNELI------RHLEAqsk-lntPLHYVIINKIQWFISQLLPISENCNYNKKGQIL-SQFPE--- 240
XP_004177699 235 nlssYKSPLFNKLRHWNELL------EKILLnte-fntPNDYILLFKFKHFLSEILPLNEESNINKFSLISKSQDSG--- 304
EDO19313     167 elisYNAPLSQKLRQWNSTL------KTIANnnk-lntEDHYIMKYKFEKFISEILPISDESNFNRSGTLSTNFDTG--- 236
XP_003684683 172 nlisYRLPLSTSLRKWNTKL------NSILNdnnkiynAQSYIMKFKFDKFLSELLPINEESNFNRSGSLYYENVNSrrd 245
7APK_A       246 neqestlgqkhtedreegmdveegemgdeeapttcsipidynlyrKFWS--------------------------LQDYF 299
XP_011276267 221 qkvy-----------------------------------knhafnAFWE--------------------------LQRAF 239
XP_002618753 255 gsaks---------------------------------gdeellqEVLS--------------------------FFRLL 275
CAR25145     222 ---------------------------------------------QLWDtkasefedap-------affndlrkvEHQFV 249
Q6CKD4       226 ---------------------------------------------TFWAphlpalpssp-------tilsdwtkiCDDFF 253 Kluyveromyces l...
Q750X0       231 ---------------------------------------------TLWAqrggklrdars-----pslfrdwtyfVEEFV 260 Eremothecium go...
XP_003646123 241 ---------------------------------------------TLWSnkhsrglssrs-----pslfadwnyfLEEFI 270
XP_004177699 305 ---------------------------------------------NVWNehsidkskrtls--ardkflddylfiLDSCL 337
EDO19313     237 ---------------------------------------------DIWHsskpsndntirrqtssekflydhsktRSRLF 271
XP_003684683 246 vafnnngskl----------------------------------------------------apkdkfaqdyhlvKNKIF 273
7APK_A       300 RNPVQCYEKI---SwKTFLKYSEEVL-AVFKSYKLDDTQAs--rKKMEELKTGG-------------------------- 347
XP_011276267 240 ANPSGILVSDr--TmSEFMSNASLVY-KKIYDAEERANDGplfvVGKKNYPTNTdkndynnsienytka----------- 305
XP_002618753 276 RDPYSHLKNP-----RMLSKSVDSMIrLSNYLLEEETKHHrkhpSPDIYAVPAPisenekqtla---------------- 334
CAR25145     250 SDPLGWAFTDpsqR-LSLERYLLPVI-DEILLHESYFYAQ----IKRKNLRLDRlkhklhlrasissgsia--------- 314
Q6CKD4       254 LHPLHWLFSHprdK-LTLEPVVHRFV-DEIFVYETELYNL----IKGKNEKHAKqeaavngkdfyplnfidnvyd----- 322 Kluyveromyces l...
Q750X0       261 LDPVGVMVSPlreR-QGFEEYTNDII-EFLLEKEQDYYRK----VASAVQGPNLirqdlhrgliptqastnnfre----- 329 Eremothecium go...
XP_003646123 271 FDPMNIMLSPvrdR-QGFEEYTNDIV-EFLLEKESEYYKR----LSEVIQQPNLirqdihknfiasqfvrnnyie----- 339
XP_004177699 338 TNPLGVVEDFldgRhSDFENTLSSLI-NKTLSYEDEFYSG----IKKHNTKILNanttlnenypieneqntnsdnnanit 412
EDO19313     272 RDPVYFFFKCtetK-STIEQYLTPLL-NVMLEAENEFYNQ----IRVTSTRISAannalnkgypfnydslkikes----- 340
XP_003684683 274 DNPINLYFNLletK-GSLNNYLMPLL-NDLLRVEDLFYNY----KQKETKKLFLmnfqsnknypsnfdiknsngmkt--- 344
7APK_A       348 ------------------------EHVYFAKFLTSEKLMDLQLSDSN-------------FRRHILLQYLILFQYLK--- 387
XP_011276267 306 ---------hlteakrqelqdfysNRDYNMSFLVNEKKFNEQIRNDQt------------FRKTFLIQLIIVLGFFSnld 364
XP_002618753 335 --------------kkyesavffpEHYWLAPFEPIQRGAQFDAVKEEdkkvaiaqfdsskFRQLVLLQIYMVSCFFLelq 400
CAR25145     315 -------vsrdmtkanknstgmspGNSQNEPFTVRPLMLDQPSWDPElvlsrlqdpfndfFRKQVVIQLVIASNLVErvl 387
Q6CKD4       323 ---epddsrnsifpskvefwkefnLESTKSENIIQLLPLELDLFDLRsfqdrieayeydyFRKLVISQVYLTFYLLKeii 399 Kluyveromyces l...
Q750X0       330 ----pqdsrhsicaskaafwkhysEVYATLEDVMHPLPLELCMEDEHtlnhqletvevdtFRKLVLLQITITCNIVDqil 405 Eremothecium go...
XP_003646123 340 ----pqdtrnmisetkvefwkvfvHNDESMNGIMHPLPLELSIFDEQnflnqletveldfFRKNMLMQIAISFNMVDtil 415
XP_004177699 413 kipnymkqnatmtqnrndfwknldDSLSFYANTFQPTWLDLSINNVEnfylqftdynndfFRKQFILQVTFALTFIKefl 492
EDO19313     341 ---sfvkssvaiqeklakhwdgfyKCYNDRKQLPSITFLDLSSKNADglfqqysrtdndyHRKQFILQFSSFVSLLNila 417
XP_003684683 345 --psylklqthgtkirlkewknfmNQFSSSKLMISPSFLELSKLDTNflyyqmikknndfFRKQFILQLCFVIGIFLqis 422
7APK_A       388 ----------GQVKFKSSN--------------YvltdeQSLWIEDTTKSVYQ-LLSE-NPPD----GERFSKMVEH--- 434
XP_011276267 365 -------------------------------daRvlddaRASFNLRKAARVATpYLYDiRNLR----REA-NNIFNAldk 408
XP_002618753 401 nskkratlknINAPASTKHi------------------qEASTPESLIKSFLQ--LKRdIPRScrawDTQLSFLFQQ--- 457
CAR25145     388 eddsikafysSqhyq--------------nldpSvg--gdSEKTLKDLGYFIKdRVRRfYEQR----DTVFQGLLDH--- 444
Q6CKD4       400 sndtlvhyygKIFNQSSLShsskwrveygdnvlN-----KNDSAINFLTKKLN-RISSfYEIR----DRQFYELLNH--- 466 Kluyveromyces l...
Q750X0       406 rdkaiyrtyvTRYKNVHSGrai---------------pnDPPTLFKFFSTAVG-RIRDfYRVK----DPQFFDMLNE--- 462 Eremothecium go...
XP_003646123 416 rdkatlkaytARYKNAHYDrif---------------ppDPPTLFKFFYSTAN-KIKEfYKQK----DYEFYEILIE--- 472
XP_004177699 493 nsndiqtfykNIFKKEDLTeresil---selneK-----NKDQIISFCNKIIElRVPQfYCSR----DRKFYDILNS--- 557
EDO19313     418 sseeasnfykTCHAKDNPTrkdyd----dsltpT------QKSLIAYFQQLFEtRIVSfYKNR----DPTFLKIILA--- 480
XP_003684683 423 espevrsfyvNSLQKDNPSkris------nmneEs---nIQKSLVAFFKNLYEtRIKAfYEEK----DPKFMNILNL--- 486
7APK_A       435 --------ILNTEENWNSWK-----NE-GCPSFVKE---RTSDTKptriIRKRTAPEDFLGkg-pTKKILMGNEELTRLW 496
XP_011276267 409 reffgnqmLISSEFTFFQAK-----LK-QFRNVETIyneVQLDDEl---YDKLKQEGAFKK----RFWALYGNAQISSHW 475
XP_002618753 458 --------LSQSEENWWAWLlygkkSD-GTSLLSEN---VLTDDEi---STTREKFETVVPyktkRYFNTHVTPQLSRRM 522
CAR25145     445 --------MLINEDALLELK-----TKrGFKIFSSF---TFPEKGl---SEAPSPKYSFKG----FGWSKFGNKKLDAAW 501
Q6CKD4       467 --------LAQNELDALNQK-----VG-DFSNLKDI---HWSSDL----ITVPTANNAFKK----FGWIKLGNKKLDGLW 521 Kluyveromyces l...
Q750X0       463 --------LLHADESFLFAK-----AA-NMAPFKEI---AWNTESl---GHAPEPACSFKK----FGFITMGNKRINDVW 518 Eremothecium go...
XP_003646123 473 --------LLHSDESFLAAK-----SK-NMAPFKEI---KWNCKPi---DGKPSFDYEFKK----FGFIKLGNKKVNDIW 528
XP_004177699 558 --------LLYSDNELLIQK-----MD-GFKKFQKF---KISEIE----NVPPTFNNNFAK----FGFILLGNKNINNVW 612
EDO19313     481 --------LIKSDEKLLSSK-----ID-GFKEFSNL---KTSGEE----IKVPSIDENFKK----FGFVKLGNKNINNVW 535
XP_003684683 487 --------LINSDSQYLKAK-----ID-GFKEFQLD---ETNAFQ----FHSIVVDRSFKK----FGFIKLGNKDINTVW 541
7APK_A       497 NLcPDNME---ACKsET-REHMPTLEeffeeaI-EQADPENMVENEyka-----vnNSNYGWRALRLLARRSphffqPT- 565
XP_011276267 476 KI-PTGLS---LLEkDTsKNTr------------EEKDKNLEILREtikstedqdlKDVVSWKALRLSRQNHlfdfkHVn 539
XP_002618753 523 KV-KTGLG---LLRtKAeVDYESEIE------KiDKELLSADLESKpel----iekRTVLIWKKLKYNRNKQwlsfgEVs 588
CAR25145     502 KT-ETGLQ---NIK-MDaESPQAVFE------ElRTEYKTEDTSVSdta-----hhDTVKQWRQMRVLRPQYvfqlgNVd 565
Q6CKD4       522 KV-QSGLDlarKYSeNNrQDPSELYD------TiISEYKDKTEKTDgdet--ttdnVIVKQWQNLRSLRPKYlfefnKVs 592 Kluyveromyces l...
Q750X0       519 KI-ESGLKrtkDLAkAReIDPTGVYS------AlQAVAATAGAATDad-------sRIVKQWQDLRALRFEYlfelaKVd 584 Eremothecium go...
XP_003646123 529 KI-ESGLDrarILSkANeINPSAVYN------KlQEEFQNSNVKNSqnsg---tdgSILKQWQLLRSLRSQYlfefnTId 598
XP_004177699 613 KL-NFNIH---DIKmDEqNNPSIVFN------NlQTVWEQNKKSTEpqnss-yddnNIVKQWQSLRSLRSEYlfnfkGLd 681
EDO19313     536 KI-DSGLD---LIKtKS-VDARENYG------IlKRKWEEDPNNEEgn-------dKIVTQWKNLRILRSQYlfdfnKVd 597
XP_003684683 542 KI-ETGID---VIKeNY-VDPTKIYN------ElENKYESGGFEEEtkt----endTIVKEWQTLRLLRSKYvfkfdSFd 606
7APK_A       566 -NQQFKSLPEYLENMVIKLAKELPPPSEE 593
XP_011276267 540 gSIGLEGLYDHSLKEADDIKRKEETEKLE 568
XP_002618753 589 --aELVENNDLTRSLEKEKLKEEQQRKSD 615
CAR25145     566 eRTGMEGLFNENVVTESQNHKKELRMERE 594
Q6CKD4       593 eKTTLAGFANEELIRNDIESKKRRLAERI 621 Kluyveromyces lactis
Q750X0       585 eTTGINGLFDPTLIAASREDKDKRISALH 613 Eremothecium gossypii
XP_003646123 599 eTTGIAGLFDPNLAKNSKENKAKNTNSYF 627
XP_004177699 682 eETGINGLFDSELVQASQNKKDDLIEKLK 710
EDO19313     598 eDTGISGLFDDSRVAASTERKDEERQNLV 626
XP_003684683 607 eDKGIKSLFDKSKKVESNKKIEDIIDEMN 635
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