Conserved Protein Domain Family
SCAI

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pfam12070: SCAI 
Protein SCAI
SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.
Statistics
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PSSM-Id: 463455
Aligned: 32 rows
Threshold Bit Score: 650.489
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q54YY1        67 HLLRKSQRLFIGLRDLPQFG-RQ-WQPFFQKTFELYTKLWKFQQQYRSILEDKskyGLKRCEIGEIASKIGQLYYHYYLR 144 Dictyostelium d...
Q94BN1        12 ALVENADRKFARVRDLPAFGrAQ--SHYFQKVFKAYMKLWNYQQSHRSKLVES---GLNRWEIGEIASRIGQLYFSQYMR 86  thale cress
XP_004957070  14 ALAEAADRKFARARDLPLYGgGD---HHSRKAFKAYTRLWRLQQERRRELVAG---GLRRWEIGEVASRIGQLYYARYLR 87 
XP_006838589  13 SMCNKADRKFAKSANLPLYGkIN-HASSFKKVFKIYTKLWKYQQDHRQKLIED---GVKRWEIGEIASRIAQIYFTQYMR 88 
XP_006576669  35 TLVDKADKKFSKIRDLPFYQrSR-HDTYFYKVFKVYTQLWKFQQENRQKLIEA---GLKRWEIGEIASRIGQLYFGQYMR 110
EEF38372      33 SLVERADKKFSKIRDLPYYErNR-YDTYFYKVFKVYTQLWKFQQENRQKLIEA---GLKRWEIGEIASRIAQLYYGQYMR 108
XP_009134734  18 SLVNKADKKFSKIRDLPFYErSR-YENYFFKVFKVYTQLWKFQQENRQKLVEA---GLKRWEIGEIASRIAQLYYGHYMR 93 
Q5Z480        35 SLLDKADRRFARVRDLPLFGrRE-PDEY-GKVFRIYTQLWRMQQEHRHRLLDA---GLRRWQVGEIAARIAHLYYSQYQR 109 Japanese rice
XP_009380875  19 SLVEVADRKFARVRDLPPTArGAlHLLHCRKAFKAYTRLWQFQQQRRRELVAG---GLRRWEIGDIASRIGQLYYGQYQR 95  wild Malaysian ...
XP_009388060  19 ALVDGADRKFALVRDLPPGArGPlQLLYFRKAFKAYTRLWQLQQRRRSELVSE---GLCRWEIGEVASRIGQLFYGQYQR 95  wild Malaysian ...
Q54YY1       145 TSDTNYLNESYIFYEAIRLRSYFKDVSLDK------TPDMMV--KQLRYYARFIVVCLLLNKK-KVVFDLIEELLKHVND 215 Dictyostelium d...
Q94BN1        87 TSEARFLLEAFVFYEAILKRSYFDEAQ---------GKDLGArfKELRFYARFLLVSLIVDRK-QMLLHLADKLRLLVDH 156 thale cress
XP_004957070  88 TAEPRSLVGAYVFYEAIYSRGYFGAAAGAEgggggrHQALLIryKELRFIARFLVVAMLMRRA-EAVDHLAGRLRALVEE 166
XP_006838589  89 TSEMNLLCESCRFYQAILEREYFKENS---------ASDLSVanKQLRCYGRFLTACLTLGKR-EMVHQVVNHMKSLLDE 158
XP_006576669 111 TSDANYLSESYIFYEAILTREYFKEGL---------FQDVNIanKQLRFLARFIMVCLVLNRR-EMVQQLVNQLKVLVDE 180
EEF38372     109 TSDAGYLSESYIFYEAILSREYFKEGL---------FQDLNLanKQLRFFARFLMVCLVLNRR-EMVHQLVNQLKLLVDE 178
XP_009134734  94 TSDAGYLAESYVFYEAILTREYFKDGL---------FQDLNIanKQLRFLARFLMVCLVLGRR-EMVHQLVEQFRRLIDE 163
Q5Z480       110 TSDTALLSEAFVFYHAVLDRGYFLADA---------ADHLFAptKHLRFLARFLLVALLLARRaDTVPRLTTHIRTLLDD 180 Japanese rice
XP_009380875  96 TSEVRFLLEAYVFYEAIVSRGYFEAARASA------APDLKLryKELRFQARFFIVALLLNRT-DEVRQLADRFRALVEE 168 wild Malaysian ...
XP_009388060  96 TSEVRFLLEAYVFYEAIMSRGYFQAAWGSV------APDLKLryKELRFHVRFLIVALLLNRT-DEAVKLADRFRALVDE 168 wild Malaysian ...
Q54YY1       216 YTKIYKPSDAQEWSLVLQEIFSFLQADQcATFSDTNQspsltnsgniinnnsnsnnnngehtNNTVQSHrlnhlnCPsp- 294 Dictyostelium d...
Q94BN1       157 SISNFRETNFKEWRLVVQEITRFIESDTnLTYLRPLR-------------------------YCAMLDS------YPas- 204 thale cress
XP_004957070 167 TKAAYPKTNFKEWKQVIQELGRFLKADGaYKGSRSLR-------------------------YDNLFDS------YPsn- 214
XP_006838589 159 HKRNFQDFSYNDWKRMLIDINRFLKADTaFMNRRPLR-------------------------YSVVLDA------DPya- 206
XP_006576669 181 CKRTFQESDFKEWKLVVQEILRFLKAETaFMNIRPLR-------------------------YSLVLDS------HPdt- 228
EEF38372     179 CRRTFQETDFKEWKLVVQEIIRFLKADSaFMNIRPLR-------------------------YSLVLDP------HPds- 226
XP_009134734 164 CKRTFQENDFKEWKVVAQEIVRFLKSDTaFMNIRPLR-------------------------YSLVLDP------NLdas 212
Q5Z480       181 SKKTLQEADYKEWKHVVQEIARFLRADSpFINMRPLR-------------------------YSYAFDP------PPdt- 228 Japanese rice
XP_009380875 169 SKAAFPATNFKEWKQVAQEISRFLKADVsSKISRPLR-------------------------YNVLFDA------HPss- 216 wild Malaysian ...
XP_009388060 169 SKAAFSATNFREWKQVVQEISRFLKADAyFKIARPLR-------------------------YNVIFDA------HPss- 216 wild Malaysian ...
Q54YY1       295 pfPLESTQI-----LQQAILVGSQQNQIKFSEITLDMFRMTQSLEYEPmseakendmklkqqltalqqqqqqqaaeakek 369 Dictyostelium d...
Q94BN1       205 qtYLARFHAkklfkFRDALLASYHRNEVKYAEVTLDTYRMMQCLEWEPsgsfyqkkpveakengfvv------------- 271 thale cress
XP_004957070 215 laSIARFHSkrvlkLKEAVLTSYHRNEVKFTELTLDTFRMLQCLEWEPtgsyqiaakeltengtvs-------------- 280
XP_006838589 207 lpSVSSIEGkralrLSDAILGSYHHNEVKFAELNLDLFRMLQCLEWEPsgsfypkrlvessesscg-------------- 272
XP_006576669 229 lpHVAAAITkrhlkLRDAVLSSFHPNEVKYSELTIDTFRMLQCLEWEPsglfyqssgsklsqn----------------- 291
EEF38372     227 llHVVTrrn---lrLRDAILTSYHHNEVKFSELTLDTFRMLQCLEWEPsgsfyqsnsikygqn----------------- 286
XP_009134734 213 tpRAsrs-----lrLTDAILSSYHYNEVKYSELTLDSFRMLQCLEWEPsgslyqsagpkmgpn----------------- 270
Q5Z480       229 lpTVPPTVKkrglvLNDAMLCSYYQNEIKFTDLTIDVFRMLQCLEWEPcgsfaltngystrd------------------ 290 Japanese rice
XP_009380875 217 fpYIARFHAnrvlrLRDALLASYRRNEIKFAELSLDTYRMVQCLEWEPsgssyqlfrkepyengafs------------- 283 wild Malaysian ...
XP_009388060 217 fpYISRFYTsrvlrLKDALLTSYHRNEIKLAEVTLDTFRMIQCLEWEPsgsfyqvpvkqpsengaln------------- 283 wild Malaysian ...
Q54YY1       370 nngtdqqnttipsqplqqhlhhqqqqqqngngSGIKKRNPHKYLLYRPTISQILLFLSYSFKELGDNKAMLLYICADGFT 449 Dictyostelium d...
Q94BN1       272 --------------dhtltsglidmnlaadmaDPSLPPNPRKAILYRPTVSHLLAVLAMICDELSPETVMLLYLSASGGP 337 thale cress
XP_004957070 281 --------------dqsgpsglidihlsteisDGSLPSNPQKAIIYHPTVSHLLAVLATICEELSQDSILLIYISASGCA 346
XP_006838589 273 ---------------eagaavpkrfsyieglvDHSLPPNPRKAILYRPAATQFISVLAAIWEDLAPDGILLIYLSAAGKA 337
XP_006576669 292 -----------------gatgtsrisyiqdiaDPTLPANPRKAVLYRPSLTHFIAVLATICEELPSDGILLVYLSASGYC 354
EEF38372     287 -----------------ggpgpsrinythditDPTLPPNSRKAVLYRPSITHLLAVLGMICEELPADGVLLIYLSASGRV 349
XP_009134734 271 ------------------aptgasrvnsqnvtDPTLPPNPRKAVLYRPSITNFLALLATICEELPSNGVVLIYLSASGKI 332
Q5Z480       291 ------------------esgqnhpnllkdlrDAALPPNPLKTILYRPSVTHFLTVLATKCEELPSNGMMLIYLSAAGEV 352 Japanese rice
XP_009380875 284 --------------dqsgasglidinlaadlmDPDLPPNPRKAVIYHPSVSQFLAVTATICEELSSDSILLIYISASGKT 349 wild Malaysian ...
XP_009388060 284 --------------dqneasglidinlavdmtDPDLPPNPCKAIIYHPSVSKLIAATATICDELPSDGILLIYISSSGKT 349 wild Malaysian ...
Q54YY1       450 NEDNhvnqhiqpppsiqqetvpsliddsntnipitttATATnplynKLFTKGLTLNMQKPSqaiNSPTVNnNnNNTTTnv 529 Dictyostelium d...
Q94BN1       338 ARENv-------------------------------aQPENsvgssRTSKSKLLARASQEQksyKSEPHSnGkLMSAEyy 386 thale cress
XP_004957070 347 EQNM---------------------------------ASQKyasssSSHATAASAFPIDKPnshMSSDnhlrlgp----- 388
XP_006838589 338 TSSSsglpl------------------------ssteQNPGdmqahDSVSDGNSISPESSSrdsPTESRNlHeENHHNgs 393
XP_006576669 355 GSAQnesgcihf-------------------------------------------------------------------- 366
EEF38372     350 GQTIsspva-----------------------gtsitTADNvvrnlYSDTASts---------pFSSPSNcPnPSSRRck 397
XP_009134734 333 GQTSlsplgg----------------------rsvtsVEENilrdfESHTIKQDGDPSVQTkpsGERPGQsLrQISEDav 390
Q5Z480       353 GSSGfc-----------------------------pdTNEMvvsslNKFDISNTSTINVNEdngprlwl----------- 392 Japanese rice
XP_009380875 350 DCSVa-------------------------------sHKNVngkstNSSKANHAPQASWKRdssPSQPATdDkLYSSTnp 398 wild Malaysian ...
XP_009388060 350 DCSVd-------------------------------fQKDVhgnslNFSKAKHTTQASQKRensLSHPAAdNnPNLSSki 398 wild Malaysian ...
Q54YY1       530 tvptttttatnvtaqttttttttnstststtsnipiykyneapfntkvESLYPMDLLPFCRKPFFLIVNSQSSDIFNEL- 608 Dictyostelium d...
Q94BN1       387 enhlwlg---------------------------------prggssgsNNLYPGDLIPFTRKPLFLIIDSDTSRAFKVLg 433 thale cress
XP_004957070 389 ------------------------------------------rgsggpNNLYPEDLIPFTRYPLFLVIDSENSHAFKAIh 426
XP_006838589 394 rgclrl----------------------------------ssrgneglNNLYPNDIIPFTRRPLFLIVDCDSSHAFKAIs 439
XP_006576669 367 ----------------------------------------gprgdrgsNCIYPSDFVPFTRRPLLLVIDNDNSKAFKVIa 406
EEF38372     398 gdclyf----------------------------------gargngglNSVYPTDLVPFTRRPLFIVIDSDVSEAFKASv 443
XP_009134734 391 ehglsf----------------------------------gshgltgpSCIYPSDLVPFTRKPLFIIIDSDNSTAFKNIc 436
Q5Z480       393 ----------------------------------------gcregegsNCIYPCDLIPFTRRPLFLVIDSNASYSFKSIh 432 Japanese rice
XP_009380875 399 gsylc-------------------------------------lgaqgsNNLYPDDLVPFTRKPLFLIIDSDSSRAFKtIh 441 wild Malaysian ...
XP_009388060 399 ghylcl----------------------------------gsqgngasNNLYPEDLVPFTRKPLFLVIDSDNSRAFKtIh 444 wild Malaysian ...
Q54YY1       609 -PTFNQPFVSLLSPQSIPKKLV-SNLKC----GNLFTFFLHDPISAFCDISCGN--KIPSKTFNNISLLAQNSLEIISKL 680 Dictyostelium d...
Q94BN1       434 gAERGEPVAMLLSP-LKPSFENpSTDDTealnGSQFTFFLTAPLQAFCQMLGLSntKPDPELCDEAESILSASFSEWETI 512 thale cress
XP_004957070 427 nAEKGEPAALLLSP-RISSAMSgVESTGh---GSQFTYFLTAPMQAFCQLAGITs-DIDTDTYANAENILFSALEEYEGI 501
XP_006838589 440 gAEMGETVALLLSPTLPSPCAAdADSTSqpnnGSQFTMFLTAPLQAFCLLVGVPgfNLGMDAFNKVDEMLSSSFDEWGKM 519
XP_006576669 407 eAEKGESVAMLLSPSCSPALS----DCShnsnGSLFTMFLTAPLQAFCMLLGLSgtDIDLDTFNKAEMLLSSSLNNWGLA 482
EEF38372     444 gSEKGEPAAILLSPSCSTPLTAv--ESSrhqsGSLFTLFLTTPLQAFCLLIGLSgsDIEMDTYNKAEALLSSSLNDWGSA 521
XP_009134734 437 gAEKGEPAALLLSPSHTPPLISa--DFSrqpsGSLFTIFLTAPVQAFCLLIGISgsDIETDVFTKAERVLSSSMNEWAST 514
Q5Z480       433 gFEKGETTAMLLSPSCRSSSAGfSGDSVrq-iGSQFTMFLTAPLQAFCHLIGNNgvDIDRDTYNKAEELLSLSLNEWATT 511 Japanese rice
XP_009380875 442 gAERGEASALLLSH-EKPLSVSeTDLTSs---GSQFTYFLTAPLQAFCQLVGLSp-DVEADIYSNAESLLSSALAEWEVT 516 wild Malaysian ...
XP_009388060 445 gAERGEASALLLSH-EKPLFLSdTNVTSg---GSQFTYFLTAPLQAFYQLIGLSs-DIEPDVYSNAESLLSSALVEWEVL 519 wild Malaysian ...
Q54YY1       681 LFECVDLHPSFSFFLLDDFLRSFIIRFIFCHATFYLHKE-F 720 Dictyostelium discoideum
Q94BN1       513 LLTSKVLNLVWAQVLPDPFLRRLILRFIFCRSVLTSFSR-T 552 thale cress
XP_004957070 502 LCTSVGLNNVWGQVVPDPFLRRLILRFIFCRAVLFyfhped 542
XP_006838589 520 LADSESLDPVWAHVLTDPFLRRLILRFIFCRGAISLyapts 560
XP_006576669 483 LATSDTLNPVWGQILGDPFIRRLLLRFIFCQAVLTLYApvy 523
EEF38372     522 LATSDTLDPVWAQILGDPFLRRLLVRFLFCRAVLTLfgpsf 562
XP_009134734 515 LAASDTLHPVWSQILKDPFLRRLLLRFIFCRAVLALYTP-V 554
Q5Z480       512 LVASSSLHPVWVEVLGDPLLRRLLLRFIFCRAAHSIFKPtY 552 Japanese rice
XP_009380875 517 LCTSKSLDRVWAQVLTDPFLRRLILRFIFCRTVLSLfcsps 557 wild Malaysian banana
XP_009388060 520 LCTSNSLDQVWAQILTDPFLRRLILRFIFCRAVLCLLRstt 560 wild Malaysian banana
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