2CFH,3KXC,2J3T


Conserved Protein Domain Family
TRAPPC6A_Trs33
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cd14944: TRAPPC6A_Trs33 
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Trs33 subunit of the TRAPP complex
TRS33 (also known as TRAPPC6A) subunit of the trafficking protein particle complex (TRAPP). TRS33 is one of the six core subunits of TRAPP complexes which play a key role in the regulation of ER-to-Golgi and intra-Golgi transport by tethering the vesicle membrane to the target membrane. In mammals, mutations in TRAPPC6a cause mosaic loss of coat pigment.
Links
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Statistics
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PSSM-Id: 271347
Aligned: 100 rows
Threshold Bit Score: 101.177
Created: 14-Jan-2014
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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BET3 interfacesynbindin
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:BET3 interface [polypeptide binding site]
Evidence:
  • Structure:2CFH; Homo sapiens Bet3-Tpc6B core of TRAPP, contacts 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           ## ### ##  #                                                                 
2CFH_C         3 DEALFLLLHNEMVSGVYksaeqg--------------------------------------------------------- 25  human
EFV55149       4 TEFPFEYLHSEIVQFLLtya------------------------------------------------------------ 23  Trichinella spi...
Q7ZXX6         3 DETLFELLHMEMVSHVFdhveed--------------------------------------------------------- 25  African clawed ...
2J3T_B         3 DTVLFEFLHTEMVAELWahdpdp--------------------------------------------------------- 25  human
Q9XU81         1 MAFPFDILHLEIIRSTLesekdrceakekfgtiidnl------------------------------------------- 37  Caenorhabditis ...
ETN84159       4 TSYPFDLLHAEIINYAKeseerrnaakqewkqvadtc------------------------------------------- 40  Necator americanus
EFO24741       8 PYFPFEFLHAEIIRYEKqrekeqidkrkswieqmrnnp------------------------------------------ 45  eye worm
EMP26175       3 DSLLFQMLHMEMAHALCae------------------------------------------------------------- 21  green sea turtle
XP_006540369   3 DAVLFEFLHTEMVAELWapdpdp--------------------------------------------------------- 25  house mouse
EUD68502      10 SLLLLIYEIIKVNNDILqnsdfdlssdasddddisggstekrlpygtdeaavgtpqreegtisgrvrergvrndavcnga 89  Plasmodium inui...

Feature 1                                                   #   #  ##  ##  #                     
2CFH_C        26 ----------------------------------evengRXITKLENMGFRVGQGLIERFTkdTARFKDELDIMKFICKD 71  human
EFV55149      24 ------------------------------------deaSVLKKLEDMGVRVGLALAEFLSmdMLPLRAEIDVVKFLCKE 67  Trichinella spi...
Q7ZXX6        26 ----------------------------------eedhgKHTRVLEGMGFRVGQGLIERLTkdSPSFKDDLEVMKFVCKD 71  African clawed ...
2J3T_B        26 ---------------------------------gpggqkMSLSVLEGMGFRVGQALGERLPreTLAFREELDVLKFLCKD 72  human
Q9XU81        38 -------------------ngpadiekyeslvqkaflhaNAETKLESIGFRVGRQLVEKVSkeSPKLVTELEIVKFICKD 98  Caenorhabditis ...
ETN84159      41 -------------------vdvteldkydslvqlafahnSYVTQLESMGYRVGYVMAERVSkeAPKLLTELEVVKFICKE 101 Necator americanus
EFO24741      46 ------------------qmevslldeqlksvkqvfiqgNAETRLEALGYRVGFVLVEKIAkdLPRLITELERMKFLCKE 107 eye worm
EMP26175      22 -------------------------------------qeKGLGALEGVGFRVGQGLSERLTkeTPSFKDELDVLKFLCKD 64  green sea turtle
XP_006540369  26 ---------------------------------gsggkrRSLSVLEGLGFRVGQALGERLPleTPAFREELDALKFLCRD 72  house mouse
EUD68502      90 ngnlladgatspnghkpsgkgkdspmhpprsaeeekisnILSGKLKGMGKDIGRKLIERVLiyRNDFSDLKDIAKLIGRD 169 Plasmodium inui...

Feature 1           #  #                    #                          #                         
2CFH_C        72 FWTTvFKKQIDNLRTNHq-gIYVLQDNKFRLLTQmsagk----qyleHASKYLAFTCGLIRGGLSNl-gIKSIVTAEVSs 145 human
EFV55149      68 FWCAiFGKQVNSLRTNHq-gIYVIYDNSFVLLQPfsnnn----qyqeEVQRYLAFTRGLIRGVLGDf-gLNAAVVADVQe 141 Trichinella spi...
Q7ZXX6        72 LWTIlFNKQIDNLRTNHq-gTYVLQDNRFMLLTQlsssk----qyleEAPKFLPYTCGLVKGALSNl-gINCTVSAEVAv 145 African clawed ...
2J3T_B        73 LWVAvFQKQMDSLRTNHq-gTYVLQDNSFPLLLPmasgl----qyleEAPKFLAFTCGLLRGALYTl-gIESVVTASVAa 146 human
Q9XU81        99 FWSSvFGKQVDNLRTNHq-gVYVVQDGRFTTLRSfpegd----qyvkESGYFLAFPCGLLRGALAGl-nIRAIVTPTIEs 172 Caenorhabditis ...
ETN84159     102 FWSAvFGKQVDNLRTNHq-gVYVVQDNKFCTLRPlaegq----qfvrEAGALVAFPCGAVRGALANl-nVNAEVTATVEt 175 Necator americanus
EFO24741     108 FWTAvFGKQVDNLRTNHq-gIYVVQDNKFFILAGfaegk----qyveESAIYLAFPCGIIRGALYNl-gITSLVTSSVEn 181 eye worm
EMP26175      65 LWITvFKKQVDNLRTNHq-gTYMLQDNNFLLLSQlsngk----qyleEAPKFLAFTCGLVKGALSNl-gFDSTVTAEVPv 138 green sea turtle
XP_006540369  73 LWAAmFQKHMDGLRTNHqvgVRAQLRHLASSLGAleppqg-ptgdvgGKNPRLTLAPTLLLGAPKGgqdCSGWQGCFFNf 151 house mouse
EUD68502     170 VWLIlFNKSVDKIQTYKk-gVYVLIDNDMGTYLNhllldnntnqkanFTHYVLVLILGIIKGILQRf-rMKGSVTYTLDy 247 Plasmodium inui...

Feature 1                    
2CFH_C       146 m-pACKFQVMIQ 156 human
EFV55149     142 m-pAVRFSINLK 152 Trichinella spiralis
Q7ZXX6       146 m-pACKFQVVIS 156 African clawed frog
2J3T_B       147 l-pVCKFQVVIP 157 human
Q9XU81       173 v-pSVKFHIQVQ 183 Caenorhabditis elegans
ETN84159     176 l-pVVKFNIHIV 186 Necator americanus
EFO24741     182 v-pAVRFHVHMQ 192 eye worm
EMP26175     139 m-pSRFPPMPYR 149 green sea turtle
XP_006540369 152 slpLRSDPCTVS 163 house mouse
EUD68502     248 --pTCTTMRKRK 257 Plasmodium inui San Antonio 1

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