Conserved Protein Domain Family
TMEM208_SND2
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pfam05620: TMEM208_SND2 
SRP-independent targeting protein 2/TMEM208
This family includes SRP-independent targeting protein 2 (SND2) from yeast and transmembrane protein 208 (TMEM208) from mammals. Both are localized to the endoplasmic reticulum (ER). SND2 works together with SND1 and SND3 in an alternative targeting route to the ER. TMEM208 regulates both ER stress and autophagy. It contains three predicted transmembrane regions. SND2 also known as Env10 in Saccharomyces cerevisiae, and its homolog as Mug69 in Schizosaccharomyces pombe. They were identified as proteins involved in vacuolar processing and morphology and meiosis, respectively.
Links
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Statistics
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PSSM-Id: 428546
Aligned: 149 rows
Threshold Bit Score: 119.578
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O14193                1 MANAAQKKLAAQNKHILTFMLAADLIVNVLFWILRFFVrs--gLSKFSKFVYAFASISSGFLHYQLHRAAAPKYDARGSL 78  Schizosa...
NP_001156228          8 TGTKGQKQILEENEATLKFYRNMIGAVSAIYIIVHLAIgn--vFSLTNIFLYTLVIASHGGSYKFMAYMSVAKFTENGQL 85 
EFX89811             10 QATKGQKQIVEENVATLNFYRNMSVVAVGVYLLFSAIFws--tTSSFDIFLICLSSFAQFCCYRFMAYMARAKYSETGQL 87 
OWR46338              9 APTKGAKQILTENAATVSFYRNMAVCAGLFFNIYVVVLny-esATFRKILMNVLVTVIYVICYQSMLYISRPHLTDTKQI 87 
NP_001040235          9 PPTKGSKQILVENAATVKFYRNMSMAATSFYGIITALFyyeniSNGVLFF-NVLVLIIHIACYQLMMYISKPRYLNNTQL 87 
Q16ZT0                8 QATKGSKQIVEENIATLKFYRNMACSSTALNILINFIFfe--pFSGLQVIMILLTTAIHGGSYYFMAMMSKPQYSDTGSL 85  yellow f...
ETN62437            153 KATKGSKQIVEENAATVKFYRNMSLIATGIQILGFLVYa---eLSTLAVIMTVLCLIAHAGSFYFMALISKPTLTEKGDI 229
WGS:AAQB:GK10746-PA   9 QATKGAKQIVEENKSTLVFYRNMAIGCSVPGLIFSFFVf---eITKLTVFMYILALLILGGSYQFMTFMSRAKYSDTGAL 85 
EDW48056              9 QGTKGAKQIVEENKTTLTFYRNMAIGCAAPALLLSFLVf---eVTKTSVFMHILSLLILGSSYQFMAFMSQAKYSESGAL 85 
EFN66812              8 ILTKGAKQIQEENVSTLSFYTNMALGAMGIYFAVTMMLf---eLTALAITIMIFSTIVYIGSYQFMAYMARTTYSESGQL 84 

O14193               79 LYVGQDL-LQEGVTSYMVDYMYFSWILIFLAALTSvKVFAFYLLVPIFVVYKAAPLLKmllqqlKNFknqalnqppqqqq 157 Schizosa...
NP_001156228         86 LDAGTDLnMEGGLAEYTKDLIILTSGCQLLSLISN-YFWFLWLLAPGQAFWILWKNFLg----pYFMq------------ 148
EFX89811             88 LDGGIDLnMESGISEQIKDAIILVSATEVLSCMSS-YFWLILLVIPCRLFHLAWKHFLs----pWFFq------------ 150
OWR46338             88 IDPGLDLnMEGGMGEHIKDVVILTSITHILAAFSE-YFWLLLLLLPIRVFWLVWVNFLg----pWFF------------- 149
NP_001040235         88 LDPGLDLnMEGGMGEHIKDIVILSSITQVLALINN-YFWLLLLILPIRVFWLLWTNILg----pWFF------------- 149
Q16ZT0               86 MDSGSDLnLDGGVAEHVKDIIILTTGSQLMSLISN-YFWLLLLLAPLRALWLLWNSVIk----pWLL------------- 147 yellow f...
ETN62437            230 IETGTDLnIEGGITEHVKDVVILTAGTQVAAILTE-YFWLLMLLLPIRAAWLLWQTVGk----qFFQ------------- 291
WGS:AAQB:GK10746-PA  86 VDSGNDLnMEGGIAENVKDLIILTSGTILLALISN-YFWFALLLVPIRAGWMLWGSVIq----pWLSq------------ 148
EDW48056             86 LDSGNDLnMEGGIAENVKDLIILTSGTLLLALISN-YFWLVLLLAPVRAGWMLWGSIIq----pWLSq------------ 148
EFN66812             85 LDSGVDLnMEGGIAEHVKDLIILTSGVQILSLISN-YFWLLWLLVPLRGSWMLWKQILa----pWFF------------- 146

O14193              158 qqqqqqhqQHATPSEPVLSKRQQKLRKKAA 187 Schizosaccharomyces pombe 972h-
NP_001156228        149 -------kAPEDNSPEINEKKQKKLERRKK 171
EFX89811            151 -------kAPTAEQDAQDDKKQRKLERRIK 173
OWR46338            150 --------QEAPQETEQDEKKRKKMERKMK 171
NP_001040235        150 --------QEAPENTEKDEKKKKKMERKYK 171
Q16ZT0              148 --------QKGEEEAPINEKK--RPERKIR 167 yellow fever mosquito
ETN62437            292 --------KDAAEEGPVNEKKQKKMMRKMN 313
WGS:AAQB:GK10746-PA 149 --------RNAQEEPELDEKKQRKMERKMR 170
EDW48056            149 -------rNAQDDNPQVDEKKQKKMDRRMR 171
EFN66812            147 --------AQPQEQPEISDKKQRKLDKKMA 168
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