Conserved Protein Domain Family
PTCRA
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pfam15028: PTCRA 
Pre-T-cell antigen receptor
The pre-T-cell antigen receptor (pre-TCR), expressed by immature thymocytes, has a pivotal role in early T-cell development, including TCR beta-selection, survival and proliferation of CD4(-)CD8(-) double-negative thymocytes, and subsequent alpha/beta T-cell lineage differentiation. This protein contains an immunoglobulin domain.
Links
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Statistics
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PSSM-Id: 464455
Aligned: 6 rows
Threshold Bit Score: 189.684
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P0C6B3        20 GIAGTPFPSLAPPVTLLVDGRRHTLVVCLVLDAAPPGLDSLVWFSGGNGSALDAFTYGPSPAPDGTWTSLGQLSLSSEEL 99  Norway rat
XP_003266305  20 GVGGTLFPSLAPPIMLLVDGKQQMVVVCLVLDVAPPGFDNPIWFSAGNGSALDAFTYGPSPATDGTWTNLAHLSLPSEEL 99 
XP_012404550  20 GMCTAPFPSMAPPLTQVVDGQQKTLVICLVLDISPSFADGSIWFSSGNGTTLDAFTYGPSPAGDGTWSSLAQLSLPAEEL 99 
1_pfamImport   1 GAVTAAFPSLAPPVTLLVAGQRRTLVVCLVLDVAAPGPDSPVWFSAGNGSALDAFTYGPAPGTDGTWTALAQLSLPAEDS 80 
VCX38305      31 GVGGTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGFGGPIWFSAGNGSSLDAFTYGPSPEADGTWTSLAQLSLPSEEL 110
Q0VCS0        31 GMGSTPFPSLAPPITLLVDGKQQTLVVCLVLDVAPPGFESPIWFSAGNGSSLDAFTYGPSPAEDGTWTRLAQLSLYSEEL 110 cattle

P0C6B3       100 EAWEPLVCHTRPAAGGLNRSTHPLQLSGeEASTDRTCPQETLRGTQRQ 147 Norway rat
XP_003266305 100 ASWEPLVCHTRPGAEGHSRSTQPLQLSG-EASTARTCPREPLSGTPSG 146
XP_012404550 100 ASWEPLVCHTGPGWQPQGPSTRPLQLSG--EPKAEKCQQELTTGPYGL 145
1_pfamImport  81 AAWESLVCHAEPGPGSPRRSTQPLRLAG------GVLPAPSCAGYQAQ 122
VCX38305     111 EAWENLVCHTGPEAGDRSQSTRPLQLSG-RDGAGAPVD----APCPSH 153
Q0VCS0       111 AAWDTLVCHTGPGAGDHGQSTQPLQLSG-DASSARTCLWEPLRGTRAL 157 cattle
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