4F52_E         3 M------------------------------------------------AVEELQSiikrcqILEEQdfKEEDFGLFQLA 34  human
Q7JRC9         1 M-------------------------------------------------QEQEME------VEVGDpaKASNLLRLIKQ 25  fruit fly
Q5U3W2         1 M------------------------------------------------ALDQLSDmvqrcqTVKDEsfSPEDYDLFTAA 32  zebrafish
Q6PCE9         1 M------------------------------------------------AAADLQSitekfqNLSEDdfKEEDTNVFLVT 32  African clawed ...
CAK48534       1 MallpvspsgclflpprvsavpprpaaispagwpslpshsftpsctsdlAMAAEED------PLIQAlpPATDYLTYLTL 74 
Q0CVJ5         1 M--------------------------------------------------AESED------PLVQAlpPATDYLTYLTL 24  Aspergillus ter...
Q2UAW5         1 M--------------------------------------------------AEEED------PIVQAlpPATDYLTYLTL 24  Aspergillus oryzae
Q7RZR9         1 M------------------------------------------------DSEKAIA------AIKEArpPATDRFTYLTI 26  Neurospora crassa
XP_001587591   1 Me-----------------------------------------------PRIDPVV------DIKANapPVGDHLAYLNF 27 
Q76PC4         1 M------------------------------------------------DWKEAIP------GAAKVaiETKDYITYSTL 26  Schizosaccharom...

4F52_E        35 GQRCIE----------EGHTDQLLEII-QnEkNKVIIKNMGWNLVGPVVRCLLCKDK---EDSKRKVYFLIFDLLVKLCN 100 human
Q7JRC9        26 LLLek----------aYDGVRMLFQSAqEsEkNTRLLPHIAMDLYHDVCLENISDEVnsqEPELFDCSDELLKLLAKYAP 95  fruit fly
Q5U3W2        33 GSTCIE----------QGDSAQVLSILvD-EkNQNIVRCMGWNLLGPLVKMLLKKE-----DKTLPHCHAILLHLLEVCS 96  zebrafish
Q6PCE9        33 CQKCLE----------EEEVALLLEIIrD-EkNQAIVKNMGWNLIGPITKCILRSSN----NDTSKICLDMIHYLCMLCN 97  African clawed ...
CAK48534      75 LEYql----------tPARLPILHKLL-Q-D--EVLTTNIGWDLVQLLLPMLPQSL-------------DCLHDIARLGN 127
Q0CVJ5        25 LEYql----------tPARLPVLHKLL-Q-D--ETLTTNIGWDLVQMLLPMLPQSS-------------ECLQDIARLGN 77  Aspergillus ter...
Q2UAW5        25 LEYql----------tPARLPTLHKLL-Q-D--EVLTTNIGWDLVQLLLPMLPQSL-------------ECLQDIARLGN 77  Aspergillus oryzae
Q7RZR9        27 VETnl----------sPAVLPTLNEVL-Q-D--AELTQEIGWDLVYNLV-NLPGSD-------------ECLETIARLGN 78  Neurospora crassa
XP_001587591  28 ITKVLIddqpa-vdlrLELLSSLNDVL-Q-D--KERANLIGWDIMPTLL-RVPGSE-------------SCLITIARLAN 88 
Q76PC4        27 LELILEearikdideqRELIKCLHEELkQ-EkNDHITREISWDIIGMVLPYVGKVQNe--AD-------EFVDFLAKNGN 96  Schizosaccharom...

4F52_E       101 PKELLLGLLELIEEPSG--------------------------------------------KQISQSILL-----LLQPL 131 human
Q7JRC9        96 LHELMLELMERLEESSS-----------------------------------------------INVFGA-----YLRAL 123 fruit fly
Q5U3W2        97 PKELLVGLLEQVEEADS--------------------------------------------GFIAETITL-----LLKPL 127 zebrafish
Q6PCE9        98 PKEVLLGLLEQIDEAAG--------------------------------------------EQISQVVLL-----LLQPL 128 African clawed ...
CAK48534     128 PREVILRVSDALMQLQPededddsddgtak------------------adeapqdatdggsKNAALPRHIlqfntLVSML 189
Q0CVJ5        78 PREVILRVSDALMQLQPeded----------------------------------------------------------- 98  Aspergillus ter...
Q2UAW5        78 PREVILRVSEALMQLQPededdddddddeenetaepaaahdtepvdtelkaatdrdaeksnIQNNLPRHVlkfnaLVAML 157 Aspergillus oryzae
Q7RZR9        79 PREVILKVLETLELLSqddgyqsdd----------------------------eseagetnGEKSVPFKQkf-itLVNML 129 Neurospora crassa
XP_001587591  89 PREIIIGVVEAMSELDLedvednwde---------------------------epieneegTAVKESNEIdrfclLLSLL 141
Q76PC4        97 PREVFLKCCELLINGGF--------------------------------------------------ESPqqfisLNSAI 126 Schizosaccharom...

4F52_E       132 QTVIQKLHNKAYS--IGLALSTLWNQLSLlpvp-yskEQIQMDDYGLcqccKALIEFTKPF------------------- 189 human
Q7JRC9       124 QVVLQRQGRDKPQa-VEWSLNSIFTHLKDlplpeylsEGYDEAQARLieqnEQVEDLLAHYitvglfr-----------e 191 fruit fly
Q5U3W2       128 QTVLLRLGMKKASs-VGMALSTLLSQVSRlpvp-vtaEQEEDDVFGLcrccSALLQFVKPFve----------------- 188 zebrafish
Q6PCE9       129 QEVLLKLGKRKAYs-VGLSLSTIHSRITClpvp-ftkEQTQEDKHGLcqccCAMVQFTKPF------------------- 187 African clawed ...
CAK48534     190 SVLHSRIQTKSPSrfLATSLQAVLEAYTLmpt---neTTYALLEFF-----RDVSPSKRPAppprvpsessv----lrls 257
Q0CVJ5        99 ---------degGrfIATSLQAALEAYTLmpt---seTTMSLLEFF-----RDVSPSKRPApppraasessv----lrvs 157 Aspergillus ter...
Q2UAW5       158 SILHSRIQTKSPSrfFATSLQAVLEAYTLmpt---neTTLALLEFF-----RDVSPSKRPApppraasessv----lrvs 225 Aspergillus oryzae
Q7RZR9       130 SILHKRIKTKYPSrfLATSLQTIYNTYRPnh-----eMTAAVINLV-----RSLAGNKRPPlptrkssvnvanpdqhgda 199 Neurospora crassa
XP_001587591 142 AIIHPRIKTKHPSrfLANSIDTITNAFHPsh-----kAVLAVGKFI-----QTLSGKKRPTlpgrksslsitnfmrhevd 211
Q76PC4       127 LSALHRISTKRPVlfVNNFLISLFSGLANi-------------------------------------------------- 156 Schizosaccharom...

4F52_E       190 ------VEEVIDNKENSLENEK--LKDELLKFCFKSLKCPLLta-------------------------qFFEQSEEGGN 236 human
Q7JRC9       192 plrdeiLQQDVRTPSQIFRDCGvnRRNIFTCFFIQLLGRPLA-----------------------------LLEMNHAKE 242 fruit fly
Q5U3W2       189 ----eiKEVVKDNNSISKDNE---LRVELLKFCMKSLSEPLLe--------------------------vQLKDTDTLQR 235 zebrafish
Q6PCE9       188 ------VDVVSQSKALIIEPDTaeLRKELLAFCFSCLKYPLLta-------------------------qLNLFPENTDD 236 African clawed ...
CAK48534     258 eksapdPEAEVQSPSPASDDESvlVQKFLQFGLIEALKSYLLsftgpsdpgmswairlqeklqpglrlakQETPSDAFAN 337
Q0CVJ5       158 easapdPEAESQSTTPADNEEPalVRRFLQFGLIELVKSYLLsfssptdpgmcwairlqeklrpgtrmpgGQSQTEAFSE 237 Aspergillus ter...
Q2UAW5       226 easapdPEAEVQSPNPS-NNEPalIKRFLQFGLIELIKSYILsfsgpmdpgmswti-rlqeklqtrhltgQVSETEVFAN 303 Aspergillus oryzae
Q7RZR9       200 tknapdPEADKDTEH---PTETaiQERLLLSFATCILESFVNkndvawaprll------efhnpekivpgRKTLMARFRE 270 Neurospora crassa
XP_001587591 212 sslptaPDPESEEEE---SYESaiQQKLLQGFAVHILGLYINehpiewagrlq------elfepervvagRTSLCVAFRV 282
Q76PC4       157 ------lQIDSDELYCVWKISIssIQDAMHRFPVSECYLACLkacsilaqlfls-----ketlmlsfrslLQTKDQYAEF 225 Schizosaccharom...

4F52_E       237 DPfryfaseIIGFLSAIGHP--FPKMIFNHGRKKrTWNYLEFE-----------------------EEENkqlADsmASL 291 human
Q7JRC9       243 DLtrsyvqqVTESLTQDANQflGDPFYLLNLVEQrARWLRKLDasrgvye---------mscqnvfLIEEklpLHavAMY 313 fruit fly
Q5U3W2       236 SPlrdfateILIILSDIGES--LPDLLSRNVLRRrKVP--GFL-----------------------EEEVrypKEslACM 288 zebrafish
Q6PCE9       237 NPffqfakdILGTFVLLGEP--LSVAFLQHGDRTpILEIEDVR-----------------------PEEGkctAEtfACL 291 African clawed ...
CAK48534     338 HKelkerdmIIAKITAPkdqp-----------------------------------------lpldFEEPprkAD----- 371
Q0CVJ5       238 SKelrerdmIMAKITALS----RDFGLEDkllleivslp------------------senqpppldFDELpkkAD----- 290 Aspergillus ter...
Q2UAW5       304 NKelserdmILGKITALS----RDFGLDDkqllavvsqp------------------adkhpqpldFDEPprnVE----- 356 Aspergillus oryzae
Q7RZR9       271 EKelsekdgAVGQLVALI----ADLGLSSCDktflsqvte-----------------gtlqtdplsKTEDiakPE----- 324 Neurospora crassa
XP_001587591 283 DPglqirdeVTGQIVALC----RDLGLADynllfdtiyatp-------------piarvrsehedpRDNLpdsPE----- 340
Q76PC4       226 REelsgattNCDKLDTLSKS---IINIFDYLLSH-LPESWSIItehmaqeltkatyvsqsssisseDEEIaknADvpAEV 301 Schizosaccharom...

4F52_E       292 AYLVFVQGIhIdQLPMVLSPLYLLQFNm--------------------gHIEVFLQRT--------EESVISKGLELLEN 343 human
Q7JRC9       314 YHSLFVGNQlPtNAPKVYAPLFLFETIv--------------------yLAEVLLRQQ--------EPPLQYCGLRLVEH 365 fruit fly
Q5U3W2       289 SHLLFVDHIaVdIFPAVFSPIFVLQCNm--------------------eYIELLLSRT--------EENRLQKGLELYEK 340 zebrafish
Q6PCE9       292 SYLLFVQHIgLdDFPFVFGPTFLLKTNm--------------------qHVDVLLKRT--------EESILSKGLELLEN 343 African clawed ...
CAK48534     372 ------------EIPLERHGSLLLLAAraataelfssg-qvspivifpdLARIFQNFVggynspdeVAFGQPQVLLDSLL 438
Q0CVJ5       291 ------------QIPLERHGALLLLAAraamaelfssg-qvipiavfpdLANIFANFVggyntpddVAFGQPQALLDSLL 357 Aspergillus ter...
Q2UAW5       357 ------------EIPLERHGALLLLAAraamaelfssg-qvtpiavfpeLAQIFDNFVgahdkpdeIAFGQPQALLDSLL 423 Aspergillus oryzae
Q7RZR9       325 ------------DIGLSTGGCVILLAYwvfsttvfdsdhpvpdmhifpdHLAMLEKFLqdd---aeDQIRKAPGTVQALV 389 Neurospora crassa
XP_001587591 341 ------------EIPLSPNGSLFLLTSlvfsslmfktkspepvmsifpdHAKLVARFFd-------SADGSSIAIVDAVV 401
Q76PC4       302 DNNSTKADDkRdEIEFDTKGCLALLTIksfyqsgnff--ldflkekfpsTILETLQQLvs-----wEIQLDSVGFKDIAV 374 Schizosaccharom...

4F52_E       344 SLLRIEDNSLL----------YQYL----EIKSFLTVPQGLVKVMTLCPIETLRKKSLAMLQLYINKLDSQG-KYTLFRC 408 human
Q7JRC9       366 HLSTLQ-HSVP----------TSSL----QLDVHKRFCEALCKIVGYSPQVALRQLGIHVLRQFVLAFDDHG-KYLILKN 429 fruit fly
Q5U3W2       341 SLVRVEENSLP----------VDLL----ELKTFFSVPQNLVKVMTMCPDQTLRTKGLKVFQLSIDKFNTEA-KYKFFRG 405 zebrafish
Q6PCE9       344 SLLRVEDESLH----------QDFL----EIKAVLHVVQDLEKVMTLCPIEHLRKRSLKLLQLMIDKFGEEG-KYKLFRC 408 African clawed ...
CAK48534     439 TLTVFSMQKPSd---------tTPH-----EKDFVDFVLTLTACTARQN----YSSVRRIPGTIIRTHPSQVtQFKVIRT 500
Q0CVJ5       358 TLTVFSMQKTIg----------tPA----TEREFQDFILALTACTARQH----FSSVRQIPGIIVHSNPSPTaRFKIIRN 419 Aspergillus ter...
Q2UAW5       424 TLTVFSMQRSIg----------ePS----TEIEFRRFILSLTACTTRQS----YNSIRRIPGTILHSHPSHIvRFKTIRL 485 Aspergillus oryzae
Q7RZR9       390 TIGLWLHDKGLisaipkaplaNQTTnpdeATSDYMRYILFVTLIAVFHPQLHVRNAASCLAGLVLHADPADDdRLKILYD 469 Neurospora crassa
XP_001587591 402 AIGLWLEHSNKf--------vSGEF----KDNDYMAHLRALSLWSATNPSPGLRYCTHKLTSAILHAHPVDAiRLVFISK 469
Q76PC4       375 YQGYLLDLPHFq---------VPDS----ELEHLSSLLHGYHFMASSTELPWLRVTCNAIVTKCLDSQLPSV-RLSYILD 440 Schizosaccharom...

4F52_E       409 LLNTSNHS----GVEAFIIQNIKNQIDMSLKRT------------------------------------RNNKWFTGPQL 448 human
Q7JRC9       430 LMGTLQHG----GLMGYLGGMYKDLVDKALGQSg-----------------------------------pMPEVYSGKLF 470 fruit fly
Q5U3W2       406 MLKTSHHA----GVEGYIIKNIKNQIDSSLKPGn------------------------------------SNDWFLGKHL 445 zebrafish
Q6PCE9       409 LFKSSNHA----GVQGYIIQNIKNQIDIALQTNs------------------------------------NSKWFLGPRL 448 African clawed ...
CAK48534     501 VLEDDRFQ----SVKDSAIGWLRTGILEAANSSkag------------------------------tsaEPSVYLDPHYF 546
Q0CVJ5       420 VLEEENYL----TVKDSAIGWLQNEILSAVNESpt---------------------------------aEPSIFLNPHYF 462 Aspergillus ter...
Q2UAW5       486 VLEDDRFQ----LIRDSAIGWLKDEILDANKKPsg--------------------------------spESDIFINPHYF 529 Aspergillus oryzae
Q7RZR9       470 LLENCDYA----SLKACAVTWLREELIAAAPNAqaapqnlaalnnqaplpspslqpgtatpgtrsragtNMNVFAGPQAL 545 Neurospora crassa
XP_001587591 470 TLQGSPDEisaiALKVSAITWLKEELITAHERKs------------------------------------QNLFSTSSVL 513
Q76PC4       441 TLEECPLL----NIKTAILNYYQKQCSLVKDSNeeg----------------------------------lknFVSPNTL 482 Schizosaccharom...

4F52_E       449 ISLLDLVLFLPEG-----------AETdllqnSDRIMASLNLLRYLVIkDNendnqt-glwtelGNIENNfLKPLHIGLN 516 human
Q7JRC9       471 REMLLLCVCVLPHd----------VKSdlllhSDRLCHALNILRYFAArDKndvtg---fwqalPEIEKElLDPLGTALN 537 fruit fly
Q5U3W2       446 LPLLRLVLCLPQG-----------PETdllqnLDRIMESLNLLRYMLI-RDkewdnetgiwtelYKIEDNyLKPMRTGLN 513 zebrafish
Q6PCE9       449 TPLLHMVLSLPEG-----------AETdllqySDRIMASLNLLRYLIIrQDnevdtktavwtelGRIENNyLKPLHIGLN 517 African clawed ...
CAK48534     547 SVVFPSLFNSSDLfmnvssdlvasFIKfsqtlSPSIHAALSLYYTIVSsPHlrkqlq--lektyVYFRNRfLEPLKSLCH 624
Q0CVJ5       463 SVLFPSLFNPAQLllnvssdivasWIKfsqslVPSIHAALNLYYILVSsADlrsrlq--lgktyLFFRNRfLEPLKTLLH 540 Aspergillus ter...
Q2UAW5       530 SILFPLLFNSSELllnvssdivasWIKfsqtlTPSIHAALSLYYILLSsSTlraqlq--lektyIYFRNRfLEPLKSLLH 607 Aspergillus oryzae
Q7RZR9       546 ETVQYVVFPNMGFlkel---dlqkLVNelgtnAPFFLQAVNFGLFLWSsADkwrrvl--ppnldATVKERwFAPLHDAVA 620 Neurospora crassa
XP_001587591 514 LETKSQIFPNLSIlvdd---sdeeLTNdlmasFAVHMAALNFLFFITAeqyani----ippgmmTQVESEyIVPLKTAQE 586
Q76PC4       483 LDVFKVFDAME-------------DVEldsqsLSYIHQTLVFLYSLEIqNLls----------qNQFPTVyFTKISDQIN 539 Schizosaccharom...