1QGX


Conserved Protein Domain Family
bisphos_HAL2
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TIGR01330: bisphos_HAL2 
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3'(2'),5'-bisphosphate nucleotidase, HAL2 family
Sulfate is incorporated into 3-phosphoadenylylsulfate, PAPS, for utilization in pathways such as methionine biosynthesis. Transfer of sulfate from PAPS to an acceptor leaves adenosine 3'-5'-bisphosphate, APS. This model describes a form found in plants of the enzyme 3'(2'),5'-bisphosphate nucleotidase, which removes the 3'-phosphate from APS to regenerate AMP and help drive the cycle. Sensitivity of this essential enzyme to sodium and other metal ions results is responsible for characterization of this enzyme as a salt tolerance protein. Some members of this family are active also as inositol 1-monophosphatase.
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Statistics
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PSSM-Id: 273558
Aligned: 5 rows
Threshold Bit Score: 534.444
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1QGX_A     2 ALERELLVATQAVRKASLLTKRIQSEVISHKdST-TITKNDNSPVTTGDYAAQTIIINAIKSNFPDDK--VVGEESSSGL 78  Saccharomyces cerev...
P32179     2 ALERELLVATQAVRKASLLTKRIQSEVISHKdST-TITKNDNSPVTTGDYAAQTIIINAIKSNFPDDK--VVGEESSSGL 78  Saccharomyces cerev...
BAA96866   2 SFDAEKQLAIAAVRRASYLTEKVFNQLIKEKsAAgALTKDDKSPVTIGDFGAQAIVISMLKDAFPNDP--IVGEEDSDFL 79  fission yeast
Q42546     2 AYEKELDAAKKAASLAARLCQKVQKALLQSd----VQSKSDKSPVTVADYGSQAVVSLVLEKELSSEPfsLVAEEDSGDL 77  thale cress
BAA97512   5 SLETEIDTAVRVVHLASSLCVKVQEKLHLPN-GGhVKSKDDDSPVTVADFGVQAIVSWVLAEVFGDQNlsIVAEEDTETL 83  thale cress

1QGX_A    79 SDa---FVSGILNEIKANDEVYNKNYKKD------DflftndQFPLKSLEDVRQIIDFGNYEGGRKGRFWCLDPIDGTKG 149 Saccharomyces cerev...
P32179    79 SDa---FVSGILNEIKANDEVYNKNYKKDdflftnD------QFPLKSLEDVRQIIDFGNYEGGRKGRFWCLDPIDGTKG 149 Saccharomyces cerev...
BAA96866  80 REn--tQTCSRVWELVQETIQHATEYK--------E------LGQIKSAEEMMSIIDQGSYHGGRNGRMWTLDPIDGTKG 143 fission yeast
Q42546    78 RKdgsqDTLERITKLVNDTLATEESFNG----------------STLSTDDLLRAIDCGTSEGGPNGRHWVLDPIDGTKG 141 thale cress
BAA97512  84 SEadslGLLGAVSNAVNEALSEAQNYGLP------K------PVKPLGSSEILKAISRCNSVGGPKGRHWVLDPVDGTLG 151 thale cress

1QGX_A   150 FLRGEQFAVCLALIVDGVVQLGCIGCPNLVLSSYGAQDLK----------GHESFGYIFRAVRGLG-AF-YSPSSD--AE 215 Saccharomyces cerev...
P32179   150 FLRGEQFAVCLALIVDGVVQLGCIGCPNLVLSSYGAQDLK----------GHESFGYIFRAVRGLG-AF-YSPSSD--AE 215 Saccharomyces cerev...
BAA96866 144 FLRGAQYAICLALIENGKPVVSAIGCPNLPYDFN--QPE------------TSPKGIIMSAVRNHG-CFqYSLHNE--KL 206 fission yeast
Q42546   142 FLRGDQYAVALGLLEEGKVVLGVLACPNLPLASIAGNNkn--------ksSSDEIGCLFFATIGSG-TYmQLLDSK---S 209 thale cress
BAA97512 152 FVRGDQYAVALALIENGKVLLGVLGCPNYPVKKECLSNGCnqamktkavaGSVSKGCVMYAKRGSGqAWmQPLIVGgiPE 231 thale cress

1QGX_A   216 SWTKIHVRHLKDTKDMITLEGVEKGHSSHDEQTAIKNKLNISKS-LHLDSQAKYCLLALGLADVYLRLPIKLsYQEKIWD 294 Saccharomyces cerev...
P32179   216 SWTKIHVRHLKDTKDMITLEGVEKGHSSHDEQTAIKNKLNISKS-LHLDSQAKYCLLALGLADVYLRLPIKLsYQEKIWD 294 Saccharomyces cerev...
BAA96866 207 EPVQVHMQDVQNTKDSKFCEGVEAGHSMQGTQEEIAKYLGITRGpTKMDSQAKYASLARGDGDIYLRLPTKMtFEEKIWD 286 fission yeast
Q42546   210 SPVKVQVSSVENPEEASFFESFEGAHSLHDLSSSIANKLGVKAPpVRIDSQAKYGALSRGDGAIYLRFPHKG-YREKIWD 288 thale cress
BAA97512 232 SATLLKVSSVDDPVLATVCEPVERANSNHLFTAGLANSMGVRKQpMRVYSMVKYAAIARGDAEVFMKFAQSS-YKEKIWD 310 thale cress

1QGX_A   295 HAAGNVIVHEAGGIHTDAMEdVPLDFGNGRTLA-T-KGVIASSGp---RELHDLVVSTSCDVIQSRNA 357 Saccharomyces cerevisiae S288c
P32179   295 HAAGNVIVHEAGGIHTDAMEdVPLDFGNGRTLA-T-KGVIASSGp---RELHDLVVSTSCDVIQSRNA 357 Saccharomyces cerevisiae S288c
BAA96866 287 HAGGSLLVEEAGGVVSDMFG-KPLDFGVGRTLK-NnNGVIAAYKgifeKVIEATAAVTSKDPHFQKVA 352 fission yeast
Q42546   289 HVAGAIVVTEAGGIVTDAAG-KPLDFSKGKYLD-LdTGIIVAN-----EKLMPLLLKAVRDSIAEQEK 349 thale cress
BAA97512 311 HAAGVVIVEEAGGVVTDAGG-RNLDFSKGVYLEgLdRGIIACSG----QVLHEKIIGAVYASWESSSL 373 thale cress
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