5JGW,2BGQ,3H7R,3H7U,5JGY,5JH1,5JH2


Conserved Protein Domain Family
AKR_AKR4C1-15
?
cd19125: AKR_AKR4C1-15 
Click on image for an interactive view with Cn3D
AKR4C family of aldo-keto reductase (AKR)
The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Links
?
Statistics
?
PSSM-Id: 381351
Aligned: 31 rows
Threshold Bit Score: 455.267
Created: 4-May-2018
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
active sitecatalytic
Conserved site includes 31 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:5JGW: Zea mays AKR4C12 in complex with cofactor NADP and acetate; contacts at 4A.
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                     ###                       #    #                              # 
5JGW_A     13 GHFVLKsGHTIPAVGLGTWrag-sdTAHSVRTAIAEaGYRHVDTAAQYGVEKEVGRGLKAAMEGgi---nRKDLFVTSKL 88  Zea mays
2BGQ_A     38 DHFVLKsGHAMPAVGLGTWrag-sdTAHSVRTAITEaGYRHVDTAAEYGVEKEVGKGLKAAMEAgi---dRKDLFVTSKI 113 barley
5JGY_A     13 GHFVLKsGHTIPAVGLGTWrag-sdTAHSVRTAIAEaGYRHVDTAAQYGVEKEVGRGLKAAMEGgi---nRKDLFVTSKL 88  Zea mays
P23901     14 DHFVLKsGHAMPAVGLGTWrag-sdTAHSVRTAITEaGYRHVDTAAEYGVEKEVGKGLKAAMEAgi---dRKDLFVTSKI 89  Hordeum vulgare
AAA21751   14 DHFVLKsGHAIPAVGLGTWrag-sdTAHSVQTAITEaGYRHVDTAAEYGVEKEVGKGLKAAMEAgi---dRKDLFVTSKL 89 
AAD22264   13 QSFKLLsGHSIPAVGLGTWksg-dkAGNAVYTAITEgGYRHIDTAAQYGVHEEVGNALQSALKAgi---nRKALFVTSKV 88 
Q43320     13 DRFVLKsGHAIPAVGLGTWrag-sdTAHSVQTAITEaGYRHVDTAAQYGIEKEVDKGLKAAMEAgi---dRKDLFVTSKI 88  Avena fatua
EFJ05725    2 TYFPLNtGAKIPAVGLGTWqsdgasCKLAVQTALEV-GYRHLDCAHLYGNEIEVGQALGAALNGgipglrREDVFVTSKF 80  Selaginella moelle...
KNH06793    4 VLLKLNtGGSIPACGLGTYrasqgeGYNAVKTAITL-GYRHIDCASIYENQTEIGKALDEVIREkl--vkRDELFITSKL 80  Perkinsela sp. CCA...
KRZ65077   16 RCFKLIsGHTIPSVGLGTWrsg-pkASDAVFTAITEaGYRYVDTAAEYGVQEEVGHGLTAAMQAgi---dRRDLFIASKI 91  Trichinella papuae

Feature 1                                    ##                                               
5JGW_A     89 WCTElaPDRVRPALEKTLKDLQlDYLDLYLIHWPFRlkdgahmpp-----eagevlelDMEGVWREMEGLVKDgLVKDIG 163 Zea mays
2BGQ_A    114 WCTNlaPERVRPALENTLKDLQlDYIDLYHIHWPFRlkdgahmpp-----eagevlefDMEGVWKEMENLVKDgLVKDIG 188 barley
5JGY_A     89 WCTElaPDRVRPALEKTLKDLQlDYLDLYLIHWPFRlkdgahmpp-----eagevlelDMEGVWREMEGLVKDgLVKDIG 163 Zea mays
P23901     90 WCTNlaPERVRPALENTLKDLQlDYIDLYHIHWPFRlkdgahmpp-----eagevlefDMEGVWKEMENLVKDgLVKDIG 164 Hordeum vulgare
AAA21751   90 WCTDlvPDRVRPALEKTLKDLQlDYLDLYLIHWPFRlkdgahkpp-----eagevlefDMEGVWKEMENLVKDgLVKDIG 164
AAD22264   89 WCEDlsPERVRPALKNTLEELQlDYLDLYLIHWPIHlkkgahmpp-----eagevlefDIGGVWREMEKLVKVgLVRDIG 163
Q43320     89 WRTNlaPERARPALENTLKDLQlDYIDLYLIHWPFRlkdgahqpp-----eagevlefDMEGVWKEMEKLVKDgLVKDID 163 Avena fatua
EFJ05725   81 WCTTdtSKRVEMALTVSLKNLGvSYLDLYLVHWPVSsqvgdatdppgnattelkkmsrRLKSIWRAMEALVERgKVRAIG 160 Selaginella moelle...
KNH06793   81 WCEYtdPSMIPGEVDKTLKELSlEYLDLYLVHWPVNmrngvpm--------raeepqpSISDTWRAMCQIPES-KVKAVG 151 Perkinsela sp. CCA...
KRZ65077   92 WCSDlaPDRVRTALKTTLQDLQlDYLDLYLIHWPFRlkegahkpq-----eagevldfDMEGVWRQMEQLVKDgLVRDIG 166 Trichinella papuae

Feature 1      ##                    #                         #######                        
5JGW_A    164 VCNYtVAKLNRLMRSANvpPAVCQMEMHPGWkNDRIFEACKKHGIHVTAYSPLGSSe----------------------- 220 Zea mays
2BGQ_A    189 VCNYtVTKLNRLLRSAKipPAVCQMEMHPGWkNDKIFEACKKHGIHITAYSPLGSSe----------------------- 245 barley
5JGY_A    164 VCNYtVAKLNRLMRSANvpPAVCQMEMHPGWkNDRIFEACKKHGIHVTAYSPLGSSe----------------------- 220 Zea mays
P23901    165 VCNYtVTKLNRLLRSAKipPAVCQMEMHPGWkNDKIFEACKKHGIHVTAYSPLGSSe----------------------- 221 Hordeum vulgare
AAA21751  165 VCNYtVTKLNRLLQSAKiaPAVCQMEMHPGWkNDKILEACKKHGIHATAYSPLCSSe----------------------- 221
AAD22264  164 ISNFtVKKLEKLLNFAEikPSVCQMEMHPGWrKHKMFEICRKYGIHTTAYSPLGSSe----------------------- 220
Q43320    164 VCNFtVTKLNRLLRSANipPAVCQMEMHPGWkNDKIFEACKKHGIHVTAYSPLGSSe----------------------- 220 Avena fatua
EFJ05725  161 VSNFgISQIQEVVSFARiiPAVNQVELHPFWrQDELVKFCQSKGIHVSAHTPLGFPgarlgssgnlssmgddevetrsqp 240 Selaginella moelle...
KNH06793  152 VSNFsTSHLMEIIAETGriPAVNQVEVHPFNrQNSLIDYCQAQGIHVSAYSPLGRG------------------------ 207 Perkinsela sp. CCA...
KRZ65077  167 VCNFtLKKLDKLLRIAQtmPSVCQMEMHPGWrNDKMLEASKKNGIHVTAYSPLGSQdr---------------------- 224 Trichinella papuae

Feature 1                # #                #              ######  #  ##                      
5JGW_A    221 ----------kNLAHDPLVEKVANKLDKtPGQVLLRWALQRGTSVIPKSTRDERIKENIQvfgWEIPEEDFRALCGIKDE 290 Zea mays
2BGQ_A    246 ----------kNLAHDPVVEKVANKLNKtPGQVLIKWALQRGTSVIPKSSKDERIKENIQvfgWEIPEEDFKVLCSIKDE 315 barley
5JGY_A    221 ----------kNLAHDPLVEKVANKLDKtPGQVLLRWALQRGTSVIPKSTRDERIKENIQvfgWEIPEEDFRALXGIKDE 290 Zea mays
P23901    222 ----------kNLAHDPVVEKVANKLNKtPGQVLIKWALQRGTSVIPKSSKDERIKENIQvfgWEIPEEDFKVLCSIKDE 291 Hordeum vulgare
AAA21751  222 ----------kNLAHDPVVEKVANKLNKtPGQVLIKWALQRGTIVIPKSSKDERIKENIQvfgWEIPEEDFQVLCSIKDE 291
AAD22264  221 ----------rDLLSDPTVLKIANKLNKsPGQLLVRWAVQRGTSVIPKSTNPERIKENIQvfgWEIPAEDFQILSSLSEQ 290
Q43320    221 ----------kNLVHDPVVEKVANKLNKtPGQVLIKWALQRGTSVIPKSSKDERIKENIQafgWEIPEDDFQVLCSIKDE 290 Avena fatua
EFJ05725  241 ivfsrsrsvhaPMLGTSAVAVIANRHRKtPAQVILRWGVQRGTSVLPRSLKPERIKSNFDilnWSLSDEDWNSVNTMEPQ 320 Selaginella moelle...
KNH06793  208 -----------ALLTHELITELSTKYNRsPAQLVLRWSIQRGCSVLPKSVNESRMRENLScddFSITEEDMEKLSSIEPQ 276 Perkinsela sp. CCA...
KRZ65077  225 ---------grDLIHDPTVTEVANKLNKtPGQVLVRWALQRGTSVIPKSTNAERIKENIQvfgWEIPEEDFRALNSIRDQ 295 Trichinella papuae

Feature 1        #
5JGW_A    291 KRVL 294 Zea mays
2BGQ_A    316 KRVL 319 barley
5JGY_A    291 KRVL 294 Zea mays
P23901    292 KRVL 295 Hordeum vulgare
AAA21751  292 KRVL 295
AAD22264  291 KRVL 294
Q43320    291 KRVL 294 Avena fatua
EFJ05725  321 LRLI 324 Selaginella moellendorffii
KNH06793  277 MRIV 280 Perkinsela sp. CCAP 1560/4
KRZ65077  296 RRVL 299 Trichinella papuae

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap