1K82,1TDZ,1EE8


Conserved Protein Domain Family
fpg

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TIGR00577: fpg 
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DNA-formamidopyrimidine glycosylase
All proteins in the FPG family with known functions are FAPY-DNA glycosylases that function in base excision repair. Homologous to endonuclease VIII (nei). This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Statistics
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PSSM-Id: 273150
Aligned: 17 rows
Threshold Bit Score: 318.089
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1K82_A         1 PELPEVETSRRGIEPHLVGATI--LHAVVRNGRLRWPVSEEI-YRLSDQPVLSVQRRAKYLLLELPEG-------WIIIH 70  Escherichia coli
P95744         2 PELPEVETVRRGLELVTLKQPIvdVEVLLARSIALPKEPQAFiEHLRDRRIEQWQRRGKYLLATLDDGs------RLVIH 75  Synechococcus e...
P19210         2 PELPEVETVKRTLTELVIGKTIagITVKWANIIKEPADVLEFeTLLMNQTIRSIRRRGKFLLFEFDDIv-------MVSH 74  Bacillus firmus
BAA05066       2 PELPEVETVRRGLEHLIVGKKIvsVEVRVPKMVKT--GVEDFqLDILGQTFESIGRRGKYLLLNLNRQt-------IISH 72  Streptococcus m...
P42371         2 PELPEVETVRRELEKRIVGQKIisIEATYPRMVLT--GFEQLkKELTGKTIQGISRRGKYLIFEIGDDf------rLISH 73  Lactococcus lac...
P55825         2 PELPEVTTVINELKETVLNKPLdqVQVNLRKVLKN-IDPQLLnKQLKNQFFTDIKRKGKYIIFLLSNGl------yLVSH 74  Mycoplasma geni...
P75402         2 PELPEVATVITELKSCVLNKPVkqVKVHLDKVLKN-TNVKQLnDALVNHSFVDIKRRGKYIIFCLSNGl------fLVSH 74  Mycoplasma pneu...
WP_003229448   4 PELPEVETVRRTLTGLVKGKTIksVEIRWPNIIKRPAEPEEFaRKLAGETIQSIGRRGKFLLFHLDHYv-------MVSH 76  Bacillus subtilis
P74290         2 PELPEVETVCRGLNRLTLEQTIggGEVLLDRSLAYPVSVEDFqKQITGCRLVGWQRRGKYLLGELRSNqapgpagWLGCH 81  Synechocystis s...
1TDZ_A         2 PELPEVETVRRELEKRIVGQKIisIEATYPRMVLT--GFEQLkKELTGKTIQGISRRGKYLIFEIGDDf------RLISH 73  Lactococcus lactis
1K82_A        71 LGMSGSLRILPEELpp-eKHDHVDLVMSNGKVLRYTDPRRFG--AWLWTKELEGHN--VLTHLGPEPL-SDDFNGEYLHQ 144 Escherichia coli
P95744        76 LRMSGQLLWLTTPQpp-cPHTRVRWFFPTRAELRFVDQRTFGrcWWLPPDCRVAEAipALATLAPEPL-SEAFTVAFLAA 153 Synechococcus e...
P19210        75 LRMEGRYGLYEK-EeplpPHTHVIFHFTDGEELRYQDVRKFG--TMHLFPKGSEEKvlPLAHLGVEPF-SEQFTSELLMN 150 Bacillus firmus
BAA05066      73 LRMEGKYLLFED-EvpdnKHFHLFFGLDGGSTLVYQDVRKFG--TFELLPKSQVEAyfVQKKIGPEPN-AKDFKLKPFEE 148 Streptococcus m...
P42371        74 LRMEGKYRLATL-DapreKHDHLTMKFADG-QLIYADVRKFG--TWELISTDQVLPyfLKKKIGPEPTyDEDFDEKLFRE 149 Lactococcus lac...
P55825        75 LRMEGKYFFEERGSkfnqKHVLVEFHFDDGSQLNYHDTRQFG--TFHLYEK--LEQaaQLNKLAFDPL-EAGFDYRKIFQ 149 Mycoplasma geni...
P75402        75 LRMEGKYFFEAKGSqfdlNHVLVEFLFQDGDQLNYHDTRQFG--TFHLFNRYQFENarELNKLALDPL-DQEFNHQAIFN 151 Mycoplasma pneu...
WP_003229448  77 LRMEGKYGLHQA-EepddKHVHVIFTMTDGTQLRYRDVRKFG--TMHLFKPGEEAGelPLSQLGPEPD-AEEFTSAYLKD 152 Bacillus subtilis
P74290        82 LRMTGQLLWTERDQqr-pRHTRVVLHFEGGWELRFVDTRTFGkvWLLPGDRPWAEVmtGLGQLGPEPF-GADFTAEYLYE 159 Synechocystis s...
1TDZ_A        74 LRMEGKYRLATL-DapreKHDHLTMKFADG-QLIYADVRKFG--TWELISTDQVLPyfLKKKIGPEPT-YEDFDEKLFRE 148 Lactococcus lactis
1K82_A       145 KCAKKKTAIKPWLMDNKLVVGVGNIYASESLFAAGIHPDRLASSLSLAECELLARVIKAVLLRSIEQGGTTLKDFLQSDG 224 Escherichia coli
P95744       154 RLAHCRRSIKTALLDQSIVAGMGNIYADESLFLSGLHPTQSAHTLTPEQVQRLHGVICQVLREGIAAGGTTIRTFMSPAG 233 Synechococcus e...
P19210       151 AFQKTNRKIKVALLDQKTVVGLGNIYVDEALFRARIHPERLAHSLSKEEMAVLHKAIVSTLEEAVEMGGSSIKSYVNGQG 230 Bacillus firmus
BAA05066     149 GLAKSHKVIKTLLLDQHLVAGLGNIYVDEVLWAAKVDPERLASQLKTSEIKRIHDETIRILQLAIEKGGSTIRSYKNSLG 228 Streptococcus m...
P42371       150 KLRKSTKKIKPYLLEQTLVAGLGNIYVDEVLWLAKIHPEKETNQLIESSIHLLHDSIIEILQKAIKLGGSSIRTYS-ALG 228 Lactococcus lac...
P55825       150 KAQNSKRKVKTFILDQTVISGIGNIYADEILFASKINPETMVDQLTIKEIEILCKNATKILAKAIVMKGTTISSFSFKKD 229 Mycoplasma geni...
P75402       152 KGHKSNKKIKTFILDQTNISGIGNIYADEILFASKIHPETLAKNLNLSQYQLICQNATDILKKAVEMKGTTIGTFTFKKD 231 Mycoplasma pneu...
WP_003229448 153 RLAKTNRAVKTALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAGGSTVRSYINSQG 232 Bacillus subtilis
P74290       160 KLKSSRRPLKNALLDQRLVAGLGNIYADEVLFFCGFHPTMASNQVSLQDCELIHQQIQATLTAAIEAGGTSFSDYRQVTG 239 Synechocystis s...
1TDZ_A       149 KLRKSTKKIKPYLLEQTLVAGLGNIYVDEVLWLAKIHPEKETNQLIESSIHLLHDSIIEILQKAIKLGGSSIRTYS-ALG 227 Lactococcus lactis
1K82_A       225 KPGYFAQELQVYGRKGEPCRVCGTPIVATKHAQRATFYCRQCQ 267 Escherichia coli
P95744       234 VNGHYGGQAWVYGRKGEACRVCGTTIERLRLAGRSSHYCPQCQ 276 Synechococcus elongatus
P19210       231 EMGMFQQKLGVYGRKNEPCRQCGTDILKTVVGGRGTHFCPNCQ 273 Bacillus firmus
BAA05066     229 EDGSMQDCLQVYGKTDQPCARCATPIEKIKVGGRGTHFCPSCQ 271 Streptococcus mutans GS-5
P42371       229 STGKMQNELQVYGKTGEKCSRCGAEIQKIKVAGRGTHFCPVCQ 271 Lactococcus lactis subsp. cremoris
P55825       230 HTGGYQNFLKVHTKKDQPCSVCNQLIVKKKINGRGSYFCLNCQ 272 Mycoplasma genitalium G37
P75402       232 HTGGYQHFLKIHGKKGKQCQSCNTTIIKKKINGRGSYICEKCQ 274 Mycoplasma pneumoniae M129
WP_003229448 233 EIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQ 275 Bacillus subtilis
P74290       240 INGNYGGMAQVYGREGEPCRHCGTVIAKIKLGGRSAHFCPQCQ 282 Synechocystis sp. PCC 6803 substr. Kazusa
1TDZ_A       228 STGKMQNELQVYGKTGEKCSRCGAEIQKIKVAGRGTHFCPVCQ 270 Lactococcus lactis
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