1X4J,4V3K


Conserved Protein Domain Family
RING-H2_RNF38-like

?
cd16472: RING-H2_RNF38-like 
Click on image for an interactive view with Cn3D
RING finger, H2 subclass, found in RING finger proteins RNF38, RNF44, and similar proteins
This subfamily includes RING finger proteins RNF38, RNF44, and similar proteins. RNF38 is a nuclear E3 ubiquitin protein ligase that plays a role in regulating p53. RNF44 is an uncharacterized RING finger protein that shows high sequence similarity to RNF38. Both RNF38 and RNF44 contain a coiled-coil motif, a KIL motif (Lys-X2-Ile/Leu-X2-Ile/Leu, X can be any amino acid), and a C3H2C3-type RING-H2 finger. In addition, RNF38 harbors two potential nuclear localization signals.
Statistics
?
PSSM-Id: 438135
Aligned: 21 rows
Threshold Bit Score: 87.3869
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H H C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:4V3K; Homo sapiens RNF38 binds two Zn2+ ions through its RING-H2 finger.
  • Comment:C3H2C3-type RING-H2 finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-H-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1             #  #              # #  #  #          #  # 
1X4J_A         22 EQTLCVVCMCDFEsrqlLRVLPCNHEFHAKCVDKWLkanrtCPICR 67   human
4V3K_C         23 EQTLCVVCMCDFEsrqlLRVLPCNHEFHAKCVDKWLkanrtCPICR 68   human
KPM10790      561 DQTMCVICMYEFEakqnLRVLPCHHEFHVRCIDKWLktnrtCPICR 606  Sarcoptes scabiei
EDV22736      477 ASKGCVICMSDFEdidcLRVLMCKHEFHTSCIDRWLktnrtCPICR 522  Trichoplax adhaerens
XP_026690284  695 DQPICVVCMSEWEpkqlLRVLPCKHEFHAKCVDRWLrsnrtCPICR 740  vase tunicate
XP_013410634  950 EQRECHICMCDYTdgenLRILTCFHEFHAPCIDRWIkdnptCPVCR 995  Lingula anatina
XP_014341769  518 GKTQCHICFCDYSkgekLRILPCLHDYHSKCIDRWLkeslsCPICR 563  coelacanth
NP_001352283  419 GKTDCQICFSEYKagerLRMLPCLHDYHVKCIDRWLkenatCPICR 464  zebrafish
XP_007907222  603 GKTQCYICFSDYLptekLRILPCIHDYHIQCIDRWLkanssCPICR 648  elephant shark
XP_021369018  775 ESEDCLICMCEYDqddrLKMLPCFHEFHEQCIDKWIkgnasCPVCR 820  Yesso scallop

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap