Conserved Protein Domain Family
7tmA_MC5R

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cd15354: 7tmA_MC5R 
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors
The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.
Statistics
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PSSM-Id: 320476
Aligned: 4 rows
Threshold Bit Score: 442.839
Created: 26-Dec-2013
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding site [chemical binding site]
Evidence:
  • Comment:based on sequence similarity to the S1P1 receptor in complex with the selective antagonist ML56.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #                       
P33032        37 GIAVEVFLTLGVISLLENILVIGAIVKNKNLHsPMYFFVCSLAVADMLVSMSSAWETITIYllnNKHLVIADAfvrhiDN 116 human
NP_775387     39 HIAPEVFLTLGLISLLENILVILAIVKNKNLHsPMYFFVCSLAVADMLVSVSNAWETIVIHllaNRSLVIEDHfirqmDN 118 zebrafish
BAA25640      37 VIAAEVFLILGIVSLLENILVICAIVKNKNLHsPMYFFVCSLAVADMLVSVSNAWETITIYlinNRHIIMEDAfvrhiDN 116 chicken
NP_001096392  37 VIAAEVFLTLGIVSLLENILVIFAIIKNKNLHsPMYFFVCSLAVADMLVSVSNAWETITINlinNRHLIMEETfvrhiDN 116 western clawed ...
Feature 1         ##  ##  #                                                               #      
P33032       117 VFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMtARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFA 196 human
NP_775387    119 VFDSLICISVVGSMWSLLAIAVDRYVTIFYALRYHNIMtVRRAGILIGSIWTFSTSCGIIFIIYSDTKPVVVCLVAMFFA 198 zebrafish
BAA25640     117 VFDSLICISVVASMCSLLAIAVDRYITIFYALRYHNIMtVKRSGLIIACIWTFCTGCGIIFILYYESTYVIICLITMFFT 196 chicken
NP_001096392 117 VFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHNIMtMRRAGIIIACIWTFCTGCGIIFILYYESTYVIICLITMFFT 196 western clawed ...
Feature 1                                                               #      #                 
P33032       197 MLFLLVSLYIHMFLLARTHVKRiaalp-gassaRQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPqnlYCSRFMS 275 human
NP_775387    199 MLLMMASLYSHMFLLARSHVKRmaalpgynaniRQRASMKGAVTLTILLGIFIVCWAPFFLHLILMISCPrniYCVCFMS 278 zebrafish
BAA25640     197 MLFLMVSLYIHMFLLARTHVKKiaalp-gynsvHQRTSMKGAITLTMLLGIFIVCWAPFFLHLILMISCPqnlYCVCFMS 275 chicken
NP_001096392 197 MLFLMVSLYIHMFLLARTHVKRiaalp-gynsvHQRTSMKGAITLTILLGIFIVCWAPFFLHLILMISCPqnlYCVCFMS 275 western clawed ...
Feature 1          #  #                         
P33032       276 HFNMYLILIMCNSVMDPLIYAFRSqEMRKTF 306 human
NP_775387    279 HFNMYLILIMCNSVIDPLIYALRSqEMRKTF 309 zebrafish
BAA25640     276 HFNMYLILIMCNSVIDPLIYAFRSqEMRKTF 306 chicken
NP_001096392 276 HFNMYLILIMCNSVIDPMIYAFRSqEMRKTF 306 western clawed frog

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