Conserved Protein Domain Family
VKG_Carbox

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pfam05090: VKG_Carbox 
Vitamin K-dependent gamma-carboxylase
Using reduced vitamin K, oxygen, and carbon dioxide, gamma-glutamyl carboxylase post-translationally modifies certain glutamates by adding carbon dioxide to the gamma position of those amino acids. In vertebrates, the modification of glutamate residues of target proteins is facilitated by an interaction between a propeptide present on target proteins and the gamma-glutamyl carboxylase.
Statistics
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PSSM-Id: 461546
Aligned: 49 rows
Threshold Bit Score: 461.277
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFN75118      96 VARALFGLCMVIDVVEERGFANIDIKWGDPWE-CHFPLIHGMRPPsLPWMIMLYTVMWIGAFGIALGLRFKLACACFALP 174
XP_001947732  43 ALRIAFGLLMMIDTMDERGFCQAEKRWMEPMK-CYFPLFDFVKPLpGRWMCLAYAAMFSGVLGVMTGFHYRISCAVYAIP 121
XP_001631057  33 ILRILFGLFMVIDIPQERGLSSLHSRWEEGM--CYFPLFNVLQPLsVDWMHIVYLVMLAGASGIFLGFMFRISCILFIIP 110
EDV21673      45 ITRVLFGFLMIFDITQERGMVYINLRWGDPKA-CEFPLLSNLPILsADWMHILYLSMIAAAIGICIGFYYRIASIWLALG 123
EDV25694      35 ITRIFYGLLMMFDITLERGMAIINVKWGNPDS-CIFPLFDFIKPLsSDWMHMLYLSMIIASFCICIGLKYHFMTTWLAIC 113
XP_002115822  49 ITRILYGFLMIVDTTQERGMEKIPYKYKDPEA-CFFPLFNILTPLsADWMHVVYLSMIIAAFCICIGFCYRFVTIWLAVC 127
XP_003228285  24 DPVPLTGLLMALDIPQERGLSYLDHKYLDGLSvCRFPLFNFLEPLpLDWMYLVYTVMLLGALGIMLGCFYRGSCLLFLLP 103
EDL91038      66 VFRFLFAFLMLLDIPQERGLSSLDRKYLDGLDvCRFPLLDALRPLpLDWMYLVYTIMFLGALGMMLGLWYRLSCVLFLLP 145
XP_016159023 123 AFRAAFGLLMALDVPQERGLGHLDQRYLDGLEvCRFPLLPFLQPLpLDWMYLLYTIMFLgALGIMLGCCYRLSCVAFLCP 202 Collared flycat...
XP_006625583  84 VFRFLFGLLMVVDIPQERGLSHLDFKYLDGAPvCRFPLFNFLKPLpLDWMYLLYVIMLFGALGIMLGCFYRLSCLMFIST 163 spotted gar
EFN75118     175 YWYIFLLDKSYWNNHTYLYGIVAILFWGTGADKYFALDASKAR-R---RDGSVPYWNYFILKFQFFVLYFLAGLKKSSRE 250
XP_001947732 122 YWYIFLADKSSWNNHSYLFGLLIAIFSVTDAHRNWSVDRWLRRkMpldAPSLVPRWNYLLLRIQFFIMYFVAGLKKFEPD 201
XP_001631057 111 YWYVFWLDKGVWNNHSYLYGLFSIMLLMTDSNRYWSLDGLINPkI---RNAEIPKWNYFLFRFQVFLVYFYAGIKKLDQD 187
EDV21673     124 HWYLILIDKTAWNNHTYLFGLFTIFFSVTNANRWWSVDGVLNQkI---NNVHIPRWNLALFQFQIFLVYFLAGVKKLNSD 200
EDV25694     114 YWYIILLDKTAWNNHTYLLGLFALFFSVTDANRWWSVDGLLDRsK---CNTAIPLWQLLLFRFQIFMVYFYAGIKKFHPD 190
XP_002115822 128 YWYVFLLDKTTWNNHSYLFGLFALFFSFTKANRWCSVDGKLDQsI---RNTHIPRWHLALFQFQIFLVYFYAGIKKLDPD 204
XP_003228285 104 YWYVFLLDKTTWNNHSYLYGLLGFQFLFINANRYWSIDGLRNPrK---RNVHVPLWNYTLLRTQVFIVYFIAGIKKLDAD 180
EDL91038     146 YWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYWSVDGLLSAqK---KNAHVPLWNYTVLRGQIFIVYFIAGVKKLDAD 222
XP_016159023 203 YWYLFLLDKTSWNNHSYLYGLLGFQLALLGADRYGSVDGLFRPrK---RNAHVPLWNYALLRAQVFIVYFIAGLKKLDAD 279 Collared flycat...
XP_006625583 164 YWYIFFLDKTTWNNHSYLYGLIGFQLTLMDANRYWSIDGLRNPkK---RNADVPLWNYTVLRAQIFIVYFIAGIKKLDSD 240 spotted gar
EFN75118     251 WLEGYAMTNLsrhWVFYPFHFFLTTEQTDFLIVHWFAFVFDLSVGFWMLLEKTRIPAMVLCTAFHLMNTRLFSIGMFPWV 330
XP_001947732 202 WLWGYSMMSLghhHVFTPFRYFFSAEFIDHWIVHVGGFLIDLFSGFGLCFRSTRPFTIIVLLAFHGMNATMFTIGMFPYV 281
XP_001631057 188 WMTGYSMTGLskeWVFDPFRAFLSDETIDLVLVHICGLCFDLFVGFFLLFDKTRPIGILFALAFNGMNSQMFHIGMFSYT 267
EDV21673     201 WITGSSVTTVgshWVFAPLRLLLTTQQISQYVLHYGGLIFDLIEGYLLFFNITRPLGIALGIYFHICNSQIFTIGIFPYA 280
EDV25694     191 WISGHSMRSLathWIFSPFRTLLTIEQINLHIVHHCGLAFDLFEGFLLYFNTTRPVGLILGCYFHFTNAWIFQIGIFPYI 270
XP_002115822 205 WITGNSMVSLeahWVFSLFHYVLTPEQVNLYIVHYGGFAFDLMEGFLLFFDITRPIGLLLGFYFHFSNACMFTIGIFPYA 284
XP_003228285 181 WVEGYSMGSLarhWLFSPFRLVLSEEMTSLLVVHGGGLALDLTAGFLLFLDATRPFALFFVSYFHCMNSQLFSIGMFSYT 260
EDL91038     223 WVEGYSMEHLsrhWLFSPFKLVLSEELTSLLVVHWCGLLLDLSAGFLLFFDASRPIGLVFVSYFHCMNSQLFSIGMFPYV 302
XP_016159023 280 WVGGFSMGTLarhWLFAPSRLVLSEELPSRLVVHGGGLVLDLSAGFLLFFDATRPLALVFVTYFHCMNSQLFSIGMFSYT 359 Collared flycat...
XP_006625583 241 WVGGYSMGYLshhWLFDPFKLVLSEEMTSLIVVHGGGLVLDLSAGYLLFFDATRPIAMFFVTYFHSMNSQLFSIGMFPYA 320 spotted gar
EFN75118     331 CLATMPLFCHVD-------------W-----PRKLGLCFDWrRKVSAADGSSiddRSkvssrsdrsgssssevlddrath 392
XP_001947732 282 CAAMIPVFCDPAtmskmlrtivesvWndksaPKSVVYKPPTrT------------------------------------- 324
XP_001631057 268 MMATLPLFCSPS-------------W-----PKKLFSRMPSwLTFILPTTDAaqqSHhclyeaa---------------- 313
EDV21673     281 MLATLHIFCNPD-------------W-----PKKVIMRLSPrWRKYFLLDTPpkySAsncyyndy--------------- 327
EDV25694     271 MLATLPIFCNPD-------------W-----PKHFVRKLRGhRQNYLVLNRYlflSYrfnnslnlgdttindgle----- 327
XP_002115822 285 MLATLPIFCRPD-------------W-----PKRLLVKTPQrWQRHFIIDAPknySSsdciav----------------- 329
XP_003228285 261 MLATSPLFCRPD-------------W-----PRRLVACLPSsLHGLLPLSRPpqpSPeciyt------------------ 304
EDL91038     303 MLASSPLFCSAE-------------W-----PRKLVARCPKrLQELLPAKAAprpSAscvy------------------- 345
XP_016159023 360 MLATNGLFCRPE-------------W-----PRGLLARCPLwLQGWLPSTKPpqpSPdchyg------------------ 403 Collared flycat...
XP_006625583 321 MMATSPLFCYAD-------------W-----PRRFFARFPScLRVLLPPITPppqPStscvypks--------------- 367 spotted gar
EFN75118     393 egkkeidrdyfaepeaeeeidggddntrlptdstepseeeeedvnvrenipgarrtTK----VTRKQKFVVSMLLCHIAL 468
XP_001947732 325 -----------------------------------------------------------------KQNAIVAGVCVYTAL 339
XP_001631057 314 --------------------------------------------------kdkqvnSKq---ASLQQLLMLTVFACYVAA 340
EDV21673     328 ------------------------------------------------npddtgsrIQq---FNSQNRLTMAILAGYVTL 356
EDV25694     328 --------------------------------------nqliknydftmpycssrrKSs---LSKRNYITFLFFSLYAVL 366
XP_002115822 330 --------------------------------------------------nsaklgIRr---FTKKNKFTLFALSCYIAI 356
XP_003228285 305 ---------------------------------------------------kgkgpRRr---PGLRQKLGAAFTLLYILE 330
EDL91038     346 ----------------------------------------------------krarAKagqkPGLRHHLGAVFTLLYLLE 373
XP_016159023 404 ----------------------------------------------------grgaRGg---LRPRQHLAAAFTILYVLE 428 Collared flycat...
XP_006625583 368 -------------------------------------------------ssdsasaPAk---PSRRHTLGTLFTLLYITE 395 spotted gar
EFN75118     469 QFFLPYSHFISKGYNNWV-PGlYGYSWDMMVHAwDTVLVVIKVHDnVNNKVRYLDPEAWV-----QSDRWVRHADMALQY 542
XP_001947732 340 QLFLPYSHIVTQGYNGWR-NGlYGYSWDMMVYNvDVAKVQIKVLDhVRREQFYLDPSGWT-----DNNKWMLHGDMLKQF 413
XP_001631057 341 QLFLPYSHFITKGYNGWT-QGlYGYSWDMMVHSwSTQHVRIKVVDqVTGKEIFIKPGAFIgggrrRHSRWNSHPDMIKQY 419
EDV21673     357 QLFLPFSHFITQGYNTWNeRGlYGYSWDMMVNSwSYPKIKILVVDlSNGKH-------FIggadsRFLRWSTYPSMIKQY 429
EDV25694     367 QLCLPFSHQITKGYIAWDgHGlYGYSWDMMIRTwITPYTKITVVDnATQQYYDLKPNTFIhniptINFRWDSHPDMMKQY 446
XP_002115822 357 QLFLPFSHNVTKGYTGWDdHGlYGYSWDMMVHTwATQHVKITVVDlSNGRQFHLKPSVCYk----YADRWNSHPDMIKQY 432
XP_003228285 331 QLFLPYSHFITQGYNNWT-NGlYGYSWDMMVHSrSHQHVKITYRDgRTGELGYLNPGVFT-----QSRRWKDHADMLKQY 404
EDL91038     374 QLFLPYSHFLTQGYNNWT-NGlYGYSWDMMVHSrSHQHVKITYRDgLTGELGYLNPGVFT-----QSRRWKDHADMLKQY 447
XP_016159023 429 QLFLPYSHFITQGYNNWT-NGlYGYSWDMMVHSrFHQHVKITYRDgLTGEVGYLKPGAFT-----QSRRWRDHADMLKQY 502 Collared flycat...
XP_006625583 396 QLFMPYSHFITQGYNNLT-NGlYGYSWDMMVHSrSHQHVKITYRDgKTGEIGYLNPGVFT-----QSRRWKDHGDMLKQY 469 spotted gar
EFN75118     543 SQCMKDNLMRR-KEkalsdsrqaeekqmwmklsANLSIYIDVWCSLNGRFQQRVFDPHVDMLTVDwHPFKPVSYLMP 618
XP_001947732 414 AGCVAANMPDR-H--------------------DNMSITMDIWGSLNGRFHQRLVDPNVDLLHAPwSPWSSVPWLLP 469
XP_001631057 420 VDCLAEKLKAR-EDld----------------iSEPAIYLDIWRSMNRRFQQRFVNPNIDILHADwSPFQKTTWVQP 479
EDV21673     430 GNCLAKQMKTSyEI-------------------KQPAVYLDIWKSMNGRFRQRLINPKVDIVSAPwSPWKKTPWLMP 487
EDV25694     447 AMCIARHAKKF-GV-------------------KKPAVYFDIWKSLNYRFQQRLVNSNIDLVSAEwSPWKATSWIMP 503
XP_002115822 433 ATCIGRRVKKL-GV-------------------KQPAVYFDIWKSMNRRFKQRTVDPSVDVLAAPwSPFTKTPWMMP 489
XP_003228285 405 ATCLSGLLQNY-NI-------------------SEPEIYFDIWVSINDRFQQRLFDPGTDIVRAEwSPFWKTPWLKP 461
EDL91038     448 ATCLSLLLPKY-NV-------------------TEPQIYFDIWVSINDRFQQRLFDPRVDIVQAVwSPFRRTPWVQP 504
XP_016159023 503 SACLSRLLPRY-NV-------------------SQPQIYFDVWVSINERFQQRLVDPRVDLVRAPwSPWTPTPWLLP 559 Collared flycatcher
XP_006625583 470 ATCLSQQLLNY-NI-------------------SEPEIYFDIWVSINERFQQRIFDPRVDIVKADwSPFRPTPWLMP 526 spotted gar
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