3X05,2YBX,2GK9


Conserved Protein Domain Family
PIPKc_PIP5KII
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cd17305: PIPKc_PIP5KII 
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Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in type II phosphatidylinositol 5-phosphate 4-kinase (PIP5KII) and similar proteins
PIP5KIIs, also known as PIPKIIs, or PI4P5KIIs, are responsible for the synthesis of phosphatidylinositol-4,5-bisphosphate (PtdIns4,5P2), an essential lipid molecule in various cellular processes, from phosphatidylinositol-5-phosphate (PtdIns5P). Three distinct PIP5KIs have been characterized in erythrocytes, PIP5K2A, PIP5K2B, and PIP5K2C isoforms.
Links
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Statistics
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PSSM-Id: 340442
Aligned: 22 rows
Threshold Bit Score: 441.711
Created: 8-Mar-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic core residues [active site], 3 residue positions
Conserved feature residue pattern:K D DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Lys proposed to bind the alpha-phosphate of ATP; mutation of this residue in PIPKI-alpha and PIPKII-alpha destroys enzyme activity.
  • Comment:1st Asp functions as a weak base
  • Comment:2nd Asp binds catalytic Mg2+ or Mn2+
  • Citation:PMID 9753329
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
3X05_A        18 PILSVLMWGVNHTINELSNVPvpvm-lmpDDFKAYSKIKVDNHLFNKenlPSRFKFKEYCPMVFRNLRERFgiDDQDYQN 96  human
XP_002111279  32 KLLSVFMWGLNYSIEQLSHVEmpvm-llpGDFKAYSKTKVENYYFNEetlPGHFKYKEYCPKVFKKLRECFdiDDEQFKQ 110 Trichoplax adha...
XP_003383716   6 PIQAVFMWGIQHSINEIMLQPepsl-lleEDFKAFSKIRVENQHYSKeylPGHFKFKEYCPIVFHDLRKRFkiDDYDYMS 84  Amphimedon quee...
ELU08768      27 PLLSVFMWGINHSINELNHVNipvm-lmpDDFKSHSKVRVDNHLFNKdnmPSHFKVKEYCPLVFRNLRERFdiDEDTYGN 105 Capitella teleta
XP_004998565  26 PLLAVFQWGCNHMMNEAELVSdqpl-ildRDFKAFSKVQVHNQYYNEqelPNKFKVKEYCPVVFKSLRHRFgeDPADYLT 104 Salpingoeca ros...
KXJ12637      29 PLLGVLMWGVNHTINELSHVNvpvm-lmpDDFKAFSKIRVDNHSYNKenlPSHFKFKEYCPMVFRHLRERFgvNDQELAK 107 Exaiptasia pallida
XP_009031498  31 PLLGIIMWGVNHSRINELSLVnppvmlmpDDFKAYSKIRIDNHLFNKenmPSHFKFKEWCPLVFRNLRERFsvDEDCYMN 110 Helobdella robusta
NP_497500     30 PVLSVFMWGINHTVDQLLHVPppgl-lmpDDFKAYSKVKIDNHNFNKdimPSHYKVKEYCPNVFRNLREQFgvDNFEYLR 108 Caenorhabditis ...
EUB56870      29 PLKSVLMWGINHSLTTLQHMKprav-lmkDDFKAYLKIKVKGHLFNKenmPSRFKFKEYCPLAFQNLRERFnvDTNDYWE 107 Echinococcus gr...
OAF69192      21 PIISILMWGINYSMSELSQATipav-llpEYFKAYLKVKVENCGFNKdklPSNYKFKEYFPMVFRDLRERFniDDEDYCT 99  Intoshia linei

Feature 1                                         #                                              
3X05_A        97 SVTrsAPINSDsqg---rcgTRFLTTYDrRFVIKTVsSEDVAEMHNILKKYHQFIVECHgntlLPQFLGMYRLTVd-GVE 172 human
XP_002111279 111 SIAf-SPLMQYgd------sGKFFVSRDkQYVVKTIdSYDVETMHLILQGYHQYIIENKgvtlLPQYLGMYRITIn-HKE 182 Trichoplax adha...
XP_003383716  85 SLTqhAHLAMDnpg---rsgSTFFVTSDkKLIIKSLsSEEVALLHQILQPYHAHIVTQEgqtlLPQYLGMYRLTVn-SAE 160 Amphimedon quee...
ELU08768     106 SLTkfCPYDCDssg---rsgARFLHSWDkKFVVKTIlSEEVAEMHRIIKDYHQHIVERHsetlLPQYMGMYRVTVn-DSE 181 Capitella teleta
XP_004998565 105 SICdgQIYGGKstg---kggGDIYYTHDhRLVIKTLaKEEVASFHHTFKQYYSYIVECDgdtlLARYLGMYRITVh-EKE 180 Salpingoeca ros...
KXJ12637     108 SFLe-SPLASSsqg---rsgAKFFTSRNkKFYIKTIeSEEVERLHTFLQEYHHYVVKQRantlLPQYLAMYRITVd-GKE 182 Exaiptasia pallida
XP_009031498 111 SLVkhCPTDIDspg---ksgARFLISHDrKYILKTItTEDVAEMIRILKDYHQYVVEHHaetrLPHILGMYKICIndTDT 187 Helobdella robusta
NP_497500    109 SLTsyEPEPDLldgsakdstPRFFISYDkKFVIKSMdSEAVAELHSVLRNYHQYVVEKQgktlLPQYLGLYRLTIe-GSE 187 Caenorhabditis ...
EUB56870     108 SFTryQPLWDSvss---ksgSKLLVTYNrHYVLKMIsSEEVEQMHNFIENYHEYIVNVHgqtlLPQYLGMYRITVn-DQD 183 Echinococcus gr...
OAF69192     100 SMTkyDPQATKdmg---rsgSKLYRSYDlKYFVKTIsKDEVSVLHKFIPHYHHYLVKNQcetlLCKYVGLYRITVn-QGE 175 Intoshia linei

Feature 1                                                                                        
3X05_A       173 TYMVVMRNVFshrLTVHRKYDLKGstvareasdkekakdlPTFKDNDFLNEgqklhvgeesKKNFLEKLKRDVEFLAQLk 252 human
XP_002111279 183 NYLIVMRSVFsamYPPHKKYDLKGssvgrvarneekakelPTFKDNDFTKDqsklyigddrNAKIMEILTRDTEFLVKFr 262 Trichoplax adha...
XP_003383716 161 TYWIVMRNILshkYKTHLKFDLKGstvdraasekekakirPTLKDNDFIQMerkimigdasKASFLSILESDVGLLEKLn 240 Amphimedon quee...
ELU08768     182 TYLLVMRHIFsprLNIHRKYDLKGstvdrqasekekskdlPTFKDNDFVNDgmdihigadaKDKLMATLNADIDFLCKQn 261 Capitella teleta
XP_004998565 181 TYMVVMNSIRpvgIPTHRLYDLKGskvdrkasdkerakdlPCLKDIDFEEAqerly-lggdTETFKETLKRDVQFLEKHn 259 Salpingoeca ros...
KXJ12637     183 TYVLVMKSVFgsrLKIHKKYDLKGstvdrqasnkekskdqPTFKDNDFTKDnvkivvgdeaKADLVEKVKDDVEFLTSLn 262 Exaiptasia pallida
XP_009031498 188 HHVMVMKNVFsagFNIHRKYDLKGstvarqasekerakelPTLKDNDFLSEktsihihkddKAKLIKILEADSTFLASLn 267 Helobdella robusta
NP_497500    188 TYLIVMRNVFgrkYGVHTKFDLKGstvsraasdkekakdlPTLKDNDFLEQnwklnlppeaGKLLIEMLTSDTEWLTRMh 267 Caenorhabditis ...
EUB56870     184 TYLLAMRNVFsprVTVHRKYDLKGsvvdreanekekskplPTLKDNDFMNDicelhleesaKQRLLEHLERDIAFLQDNn 263 Echinococcus gr...
OAF69192     176 TYILVQKSCFppiYPIHKKYDLKGstvsrqattkerkkelPTLKDNDFMNEltyidvdvesREILLEKLKSDVEFLRMQs 255 Intoshia linei

Feature 1          #                                                                             
3X05_A       253 imDYSLLVGIHDVdraeqeemeveeraedeecendgvggnllcsygtppd------------------------------ 302 human
XP_002111279 263 imDYSLLLGIHDIerglkernhedeedcldeadgssdentngddv----------------------------------- 307 Trichoplax adha...
XP_003383716 241 lmDYSLLVGITDFgaaptdsddeewlddddvdfsgdelredsptsplpddmgksnvegeptspvpptgasppkaeelv-- 318 Amphimedon quee...
ELU08768     262 lmDYSLLVGIHDVdraeqelnesgddeengceeeedeeeaegggsppd-------------------------------- 309 Capitella teleta
XP_004998565 260 lmDYSLLVAIHDCneqtpgeidrdvdvy---------------------------------------------------- 287 Salpingoeca ros...
KXJ12637     263 imDYSLLLGIHDCelaeagdafdedegvgdesrcesneesdpdspqegelsasp-------------------------- 316 Exaiptasia pallida
XP_009031498 268 lmDYSLLVGIHEVnhpsnfvdeddeeeddedleqedennandssmfttpps----------------------------- 318 Helobdella robusta
NP_497500    268 lmDYSLLVGIHDCeraaqeaanrpveqnseesgdelaptppdspip---------------------------------- 313 Caenorhabditis ...
EUB56870     264 lmDYSALIGIHDVelavdndmeeasgtglgypasaspvnvevgsgttaggvgiagmgghrgsgaemlasagdglgeifee 343 Echinococcus gr...
OAF69192     256 vmDYSLIIGVHDLdavinsdvendeecqyptmtnsesdrmskitqkstds------------------------------ 305 Intoshia linei

Feature 1                                                                                        
3X05_A       303 ------------------------------------------------------------------spgnllsfprffgp 316 human
XP_002111279 308 -----------------------------------------------------------------------ddspaasps 316 Trichoplax adha...
XP_003383716 319 -------------------------------------vikedeviekepsgsptgaaspvyrpilvngekevvqakadgy 361 Amphimedon quee...
ELU08768     310 -------------------------------------------------------------------spaaylvsqpsft 322 Capitella teleta
XP_004998565     --------------------------------------------------------------------------------     Salpingoeca ros...
KXJ12637     317 -------------------------------------------------------------pdtppatdedrfrslsvgs 335 Exaiptasia pallida
XP_009031498 319 ----------------------------------------------------------------sprirtesdgdyvyey 334 Helobdella robusta
NP_497500    314 ----------------------------------------------------------------------stggafpgvs 323 Caenorhabditis ...
EUB56870     344 rlfgpthsntasfipsslpvgsfphagvgvglsnepfsdfsppnsenfdtlvalgsaeegaytppespsddlshrfqpft 423 Echinococcus gr...
OAF69192     306 -----------------------------------------------------------------ddnvdlvnvyeadqv 320 Intoshia linei

Feature 1                                     #                                                  
3X05_A       317 gefdpsvdvyamkshesspkkeVYFMAIIDILTpYDTKKKAAHAAKTVKHGAga-------------------------e 371 human
XP_002111279 317 paevcdnnvyaiscsttctnqeIYYLAIVDVLTqYGARKKAAHMAKTAKHGAga-------------------------e 371 Trichoplax adha...
XP_003383716 362 ypiidksvdifavlslpesrkeVYYIAIIDVLTnYGARKRAAHAAKTMKHGHga-------------------------e 416 Amphimedon quee...
ELU08768     323 geidpgierfgiksseesghheVYFLALVDILThYGMKKRTAQAAKTVKHGAga-------------------------e 377 Capitella teleta
XP_004998565 288 -------hvgphakdlkadpkrLYFIGIIDVLTvYSTRKRAAHAAKTAKHGAra-------------------------e 335 Salpingoeca ros...
KXJ12637     336 dcddkeddfifsvhsteggkreIYFMGIIDVLTyYGAGKKAAHAAKTVKHGLstskpwrrvslnhnegnlapnqhwagae 415 Exaiptasia pallida
XP_009031498 335 epdqndpgyfaiksndkspqpvIYFMSLIDILTrYGVKKKTAKAAKTMKHGAga-------------------------e 389 Helobdella robusta
NP_497500    324 ggpdlddefyaiaspadfeknlIYFIGLVDILTyYGIKKRSATAAKTVKYGSdae------------------------n 379 Caenorhabditis ...
EUB56870     424 gdlnpisefyafrgspslgrpvIYFIALIDILTrYGMRKRTAQTYKTVKHGGana-----------------------dq 480 Echinococcus gr...
OAF69192     321 iieavniesiasdnnrgtsanhIYIVGIIDFNTtYGMKKRTAHSAKTLKHGAda-------------------------e 375 Intoshia linei

Feature 1                           
3X05_A       372 iSTVNPEQYSKRFNEFMSN 390 human
XP_002111279 372 iTTVNHKQYAERFMAFIGR 390 Trichoplax adhaerens
XP_003383716 417 iSTVKPGQYARRFLDFVHK 435 Amphimedon queenslandica
ELU08768     378 iSTVKPDQYARRFLDFVAR 396 Capitella teleta
XP_004998565 336 iSTVKPDQYAKRLLEFVSS 354 Salpingoeca rosetta
KXJ12637     416 iSTVKPENYAKRFLEFIDR 434 Exaiptasia pallida
XP_009031498 390 iSTVKPDQYAKRFMEFIDR 408 Helobdella robusta
NP_497500    380 iSTVKPEQYAKRLVEFVSR 398 Caenorhabditis elegans
EUB56870     481 iTTVRPEVYGRRLLDFLRN 499 Echinococcus granulosus
OAF69192     376 iSTVNPDQYAKRFINFISK 394 Intoshia linei

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