5UVM


Conserved Protein Domain Family
DcpS_C
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pfam11969: DcpS_C 
Scavenger mRNA decapping enzyme C-term binding
This family consists of several scavenger mRNA decapping enzymes (DcpS) and is the C-terminal region. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' decay of an mRNA. The association of DcpS with 3' to 5' exonuclease exosome components suggests that these two activities are linked and there is a coupled exonucleolytic decay-dependent decapping pathway. The C-terminal domain contains a histidine triad (HIT) sequence with three histidines separated by hydrophobic residues. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function.
Links
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Statistics
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PSSM-Id: 463415
Aligned: 64 rows
Threshold Bit Score: 84.1941
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5UVM_A           36 NCVFCKIIKRELPSTIYYED--------ERVIAIKDIN--------PA---APVHVLIIPKE-HIANVKEINESNAQILI 95  Acetivibrio ...
A0EGQ1          118 DWVYNILEKKKEVENIVFEN--------QTFLILKDYVf------vNSqslDDLHLLALPFQrDIKSLRDLNQDHVAMLE 183 Paramecium t...
CAP31825        148 NWVYNCLEKRSEVDKIVYEDpd----knNGFLLLQDIKw-------DGktiENLYVLAIIHRhGLKSVRDLTGDDLEMLY 216
Q6C6M8           30 KWADGVLYRDESPQDVIYGDld----qkTGFVLFIHQKw-------NErdfRELNLIAIAYRhDVHSLRDLVPDHVDWLQ 98  Yarrowia lip...
Q0U2I6          148 NWVFNIIEGRTEQEDVMYREsd----psKGFLLLPDLNw-------DRktiGALHLLGLVERrDIWSVRDLKKGNVEWLK 216 Parastagonos...
XP_001272646    149 NWVFNILEGRTEQEDVILRDagk--gpdDGFLMLPDLNw-------DRktmGSLHLLGLPLRrDIWSLRDLKKKHVPWLR 219
XP_001543935    141 NWVYNIIEGRKEQEDVIIRVsd----peEGFLLLPDLNw-------DRktiGTLRLLCLVERrNIWSLRDLKKKHIPWLK 209
Q2H304          151 NWAFNIIEGTKEAEDVIYRTpygq-dpeEGFLLLPDLNw-------DRktlDALHLLGLVERrDLWSLRDLRKKHIPWLR 222 Chaetomium g...
Q5K774          142 GWVYEILEGRKEAERVYYRSeg-----dDGFVILPDLKw-------DEttkNALYLTCIVQDrSIKSLRDLKVSHISLLK 209 Cryptococcus...
jgi:OSTLU_34772  99 AWVRKILSLEKERERLLHCDddfllnvdSKWTTHPDCDgadratwrAHssvTDLYCLGLCVReDFKSLRDARAEHLPLLR 178

5UVM_A           96 DIHKAANKVAEDLGIAekGYRLITNCGVAAGQTVFHLHYHLLG--------GVDXG 143 Acetivibrio thermocellus DSM 1313
A0EGQ1          184 EMYTEGLKIISEKY-Q--LESKFVKVFVHYLPSFYHFHVHFTHssq-----mgQAF 231 Paramecium tetraurelia
CAP31825        217 NIRDKSLTAINEKY-G--LQKDQIKCYFHYQPSFYHLHVHFINlkydapasT--TM 267
Q6C6M8           99 SMRNQVVNILPEIYGIk-MKSMQPVLYVPYPPGKYHFHFLIREksspilqeELRSG 153 Yarrowia lipolytica
Q0U2I6          217 HMKIKMVEATCGLYEG--VERDQLKLYVHYQPTYYHFHIHIVHvale-agnTQATG 269 Parastagonospora nodorum SN15
XP_001272646    220 YLRQRLLEGTVKMYPE--LEQDQLKLYVHYQPTYYHFHIHVVNvmle-agaTQATG 272
XP_001543935    210 HMREKVLDGVVNVYPQ--LDRDQLKLYLHYQPTYYHLHIHVVNimle-ggtTQSTG 262
Q2H304          223 HMRAKFLDAATGVYPS--IERDQLKLYVHYQPTYYHLHIHIVHvale-agaTQATG 275 Chaetomium globosum CBS 148.51
Q5K774          210 NIREKAAAEASKRF-G--VDAGNLRLFVHYHPTYYHFHVHIVHirhdnlfgQVAGQ 262 Cryptococcus neoformans
jgi:OSTLU_34772 179 AMLRKGRAVIEDIY-G--VNAEEMRVFVHYPPQFYHFHVHYQAlsakeqgcA--CE 229
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